“Wow-I Can Touch That?” Using Special Collections to Expand Information Literacy

What happens when undergraduates get their hands on a nineteenth-century stereoscope, a first edition of _Tom Jones_, and 100-year-old student handbooks during an information literacy session? And what do these students learn through analyzing primary sources that can sharpen their responses to other kinds of scholarly evidence? To answer these questions, participants in this interactive workshop will recreate an instruction session developed by librarians at Grinnell College using surrogates of primary sources to prompt discussion of any source\u27s audience, authorship, reliability, and purpose. This workshop will begin with an overview of how librarians at Grinnell, a small liberal arts institution, have successfully collaborated with disciplinary faculty to select materials and to plan information literacy sessions focused on examination and discussion of primary sources; we\u27ll also share how these sessions have been integrated into a first-year seminar, an introductory history course, an upper-division education class, and a French literature seminar. Our specific objectives for this session are that participants will i) learn successful strategies for using rare books, manuscripts, and archival resources in information literacy sessions; ii) consider the advantages and disadvantages of digital facsimiles from databases such as ECCO (Eighteenth Century Collections Online) and original texts; and iii) articulate ways their own college or university special collections might be used to expand information literacy instruction. Participants will also receive a list of questions for students to consider when using primary evidence

Architecture in Mission Integration, Choreographing Constraints

In any building project the Architect's role and skill is to balance the client's requirements with the available technology, a site and budget. Time, place and resources set the boundaries and constraints of the project. If these boundaries are correctly understood and respected by the Architect they can be choreographed into producing a facility that abides by those constraints and successfully meets the clients needs. The design and assembly of large scale space facilities whether in orbit around or on the surface of a planet require and employs these same skills. In this case the site is the International Space Station (ISS) which operates at a nominal rendezvous altitude of 220 nautical miles. With supplies to support a 7 day mission the Shuttle nominally has a cargo capacity of 35,000 pounds to that altitude. Through the Mission Integration process the Launch Package Management Team choreographs the constraints of ascent performance, hardware design, cargo, rendezvous, mission duration and assembly time in order to meet the mission objective

Water and Sanitation for Disabled People and Other Vulnerable Groups

Water and Sanitation for Disabled People and Other Vulnerable Group

Personal and societal costs of multiple sclerosis in the UK: A population-based MS Registry study

ObjectivesTo investigate through survey and data linkage, healthcare resource use and costs (except drugs), including who bears the cost, of multiple sclerosis in the United Kingdom by disease severity and type.MethodsThe United Kingdom Multiple Sclerosis Register deployed a cost of illness survey, completed by people with multiple sclerosis and linked this with data within the United Kingdom Multiple Sclerosis Register and from their hospital records. Resource consumption was categorised as being medical or non-medical and costed by National Health Service and social services estimates for 2018.ResultsWe calculated £509,003 in non-medical costs over a year and £435,488 in medical costs generated over 3 months. People with multiple sclerosis reported self-funding 75% of non-medical costs with non-medical interventions having long-term potential benefits. Costs increased with disability as measured by patient-reported Expanded Disability Status Score and Multiple Sclerosis Impact Scale, with Multiple Sclerosis Impact Scale physical being a more powerful predictor of costs than the patient-reported Expanded Disability Status Score. Two distinct groups were identified: medical and non-medical interventions (n = 138); and medical interventions only (n = 399). The medical and non-medical group reported increased disease severity and reduced employment but incurred 80% more medical costs per person than the medical-only group.ConclusionsThe importance of disability in driving costs is illustrated with balance between medical and non-medical costs consistent with the United Kingdom health environment. People with multiple sclerosis and their families fund a considerable proportion of non-medical costs but non-medical interventions with longer term impact could affect future medical costs

Determining the optimal time interval between sample acquisition and cryopreservation when processing immature testicular tissue to preserve fertility

The cryopreservation of immature testicular tissue (ITT) prior to gonadotoxic therapy is crucial for fertility preservation in prepubertal boys with cancer. However, the optimal holding time between tissue collection and cryopreservation has yet to be elucidated. Using the bovine model, we investigated four holding times (1, 6, 24, and 48 h) for ITTs before cryopreservation. Biopsies from two-week-old calves were stored in transport medium and cryopreserved following a standard slow-freezing clinical protocol. Thawed samples were then assessed for viability, morphology, and gene expression by haematoxylin and eosin (H&E) staining, immunohistochemistry and real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR). Analysis failed to identify any significant changes in cell viability when compared between the different groups. Sertoli (Vimentin+) and proliferating cells (Ki67+) were well-preserved. The expression of genes related to germ cells, spermatogenesis (STRA8, PLZF, GFRα-1, C-KIT, THY1, UCHL-1, NANOG, OCT-4, CREM), and apoptosis (HSP70-2) remained stable over 48 h. However, seminiferous cord detachment increased significantly in the 48-h group (p < 0.05), with associated cord and SSC shrinkage. Collectively, our analyses indicate that bovine ITTs can be stored for up to 48 h prior to cryopreservation with no impact on cell viability and the expression levels of key genes. However, to preserve the morphology of frozen-thawed tissue, the ideal processing time would be within 24 h. Testicular tissues obtained from patients for fertility preservation often need to be transported over long distances to be cryopreserved in specialist centres. Our findings highlight the importance of determining optimal tissue transport times to ensure tissue quality in cryopreservation

Macro Micro Studio:A Prototype Energy Autonomous Laboratory

In 2011, the Departments of Architecture, Physics and Engineering began the development of a small Passivhaus standard, renewable energy self-sufficient studio at the University Botanical Gardens in Dundee. The prototype was conceived as an experimental, integrated technical platform to monitor the performance of an ultra-low-energy consumption, energy positive building in the Scottish climate, and understand user behaviour in relation to managing energy in-use and reducing occupant’s energy consumption. The building fabric has been constructed using regional sustainable materials, including a low-thermal bridging timber kit relying on Scottish small cross-section timber and a novel foam concrete (air entrained) slab foundation. While further work is required to complete the installation of the renewable energy system, predictive modelling indicates that energy autonomy can be largely achieved. With the recent introduction of the new Passivhaus 2009 criteria in October 2015, this project provides an insight into the practical application of an autarkic energy system in a northern European climate. The following paper describes the research rationale, the processes and decision making in the development of the formal and technical design of the building and discusses our current thinking in the design and quantification of the energy system

Why does the NHS struggle to adopt eHealth innovations? A review of macro, meso and micro factors

Abstract Background Having a tax-funded and supposedly ‘National’ Health Service (NHS), one might assume that the UK is well-positioned to roll out eHealth innovations at scale. Yet, despite a strong policy push, the English NHS has been limited in the extent to which it has exploited the potential of eHealth. Main body This paper considers a range of macro, meso and micro factors influencing eHealth innovation in the English NHS. Conclusions While barriers to eHealth innovation exist at all scales, the fragmentation of the NHS is the most significant factor limiting adoption and diffusion. Rather than addressing problems of fragmentation, national policy seems to have intensified the digital divide. As the recently published NHS Long Term Plan places great emphasis on the role of digital transformation in helping health and care professionals communicate better and enabling people to access the care they need quickly and easily, the implications for the digital divide are likely to be significant for effectiveness, efficiency and equity