3,836 research outputs found
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Adapting Three-Dimensional Shock Control Bumps for Swept Flows
Shock control bumps offer the potential to reduce wave drag on transonic aircraft wings. However, most studies to date have only considered unswept flow conditions, leaving uncertain their applicability to realistic finite swept wings. This paper uses a swept infinite-wing model as an intermediate step, and it presents a computational study of the design drag performance of three-dimensional bumps. A new geometric parameter, termed bump orientation, is introduced and found to be crucial to the performance under swept flows. Classic shock control bumps aligned approximately with the local to freestream flow direction can offer drag reductions comparable to those from similar but unoriented devices in unswept flows, whereas badly misaligned bumps see severe performance degradation. For appropriately aligned classic bumps, the relationships between performance and selected geometric parameters (height, streamwise position, and isolation) are found to be somewhat similar to those observed in unswept studies.The authors would like to thank the United Kingdom Engineering and Physical Sciences Research Council for funding the research
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Utilization of Away-From-Home Food Establishments, Dietary Approaches to Stop Hypertension Diet Pattern, and Obesity
Eating meals away from home has been associated with the consumption of unhealthy foods and increased body weight. However, more rigorous assessment of the contribution of different types of away-from-home food establishments to overall diet quality and obesity is minimal. This study examined usage of these food establishments, accordance to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and obesity status in a nationally representative sample of adults in the United Kingdom.
A cross-sectional analysis of data from a national survey (N=2,083 aged ≥19 years, from 2008 to 2012) with dietary intake measured using a 4-day food diary, and height and weight measured objectively. Exposures included usage of (i.e., by proportion of energy) all away-from-home food establishments combined, and fast-food outlets, restaurants, and cafés separately. Outcomes included accordance with the DASH diet, and obesity status. Multivariable logistic regressions were conducted in 2016 to estimate associations between food establishments, diet quality, and obesity.
People consuming a higher proportion of energy from any away-from-home food establishment had lower odds of DASH accordance (OR=0.45, 95% CI=0.31, 0.67) and increased odds of obesity (OR=1.48, 95% CI=1.10, 1.99). After adjustment, only use of fast-food outlets was significantly associated with lower odds of DASH accordance (OR=0.48, 95%=0.33, 0.69) and higher odds of obesity (OR=1.30, 95% CI=1.01, 1.69).
Although a greater reliance on eating away-from-home is associated with less-healthy diets and obesity, dietary public health interventions that target these food establishments may be most effective if they focus on modifying the use of fast-food outlets.The work was undertaken by the Centre for Diet and Activity Research, a UK Clinical Research Collaboration Public Health Research Centre of Excellence. Funding from the British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, the National Institute for Health Research, and the Wellcome Trust, under the auspices of the UK Clinical Research Collaboration [RG72218], is gratefully acknowledged. In addition, Dr. Penney’s PhD studentship is generously supported by the Cambridge International Scholarship, a scheme funded by the Cambridge Commonwealth, European, and International Trust
E-QED: Electrical Bug Localization During Post-Silicon Validation Enabled by Quick Error Detection and Formal Methods
During post-silicon validation, manufactured integrated circuits are
extensively tested in actual system environments to detect design bugs. Bug
localization involves identification of a bug trace (a sequence of inputs that
activates and detects the bug) and a hardware design block where the bug is
located. Existing bug localization practices during post-silicon validation are
mostly manual and ad hoc, and, hence, extremely expensive and time consuming.
This is particularly true for subtle electrical bugs caused by unexpected
interactions between a design and its electrical state. We present E-QED, a new
approach that automatically localizes electrical bugs during post-silicon
validation. Our results on the OpenSPARC T2, an open-source
500-million-transistor multicore chip design, demonstrate the effectiveness and
practicality of E-QED: starting with a failed post-silicon test, in a few hours
(9 hours on average) we can automatically narrow the location of the bug to
(the fan-in logic cone of) a handful of candidate flip-flops (18 flip-flops on
average for a design with ~ 1 Million flip-flops) and also obtain the
corresponding bug trace. The area impact of E-QED is ~2.5%. In contrast,
deter-mining this same information might take weeks (or even months) of mostly
manual work using traditional approaches
A Upf3b-mutant mouse model with behavioral and neurogenesis defects.
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts. NMD is regulated in a tissue-specific and developmentally controlled manner, raising the possibility that it influences developmental events. Indeed, loss or depletion of NMD factors have been shown to disrupt developmental events in organisms spanning the phylogenetic scale. In humans, mutations in the NMD factor gene, UPF3B, cause intellectual disability (ID) and are strongly associated with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and schizophrenia (SCZ). Here, we report the generation and characterization of mice harboring a null Upf3b allele. These Upf3b-null mice exhibit deficits in fear-conditioned learning, but not spatial learning. Upf3b-null mice also have a profound defect in prepulse inhibition (PPI), a measure of sensorimotor gating commonly deficient in individuals with SCZ and other brain disorders. Consistent with both their PPI and learning defects, cortical pyramidal neurons from Upf3b-null mice display deficient dendritic spine maturation in vivo. In addition, neural stem cells from Upf3b-null mice have impaired ability to undergo differentiation and require prolonged culture to give rise to functional neurons with electrical activity. RNA sequencing (RNAseq) analysis of the frontal cortex identified UPF3B-regulated RNAs, including direct NMD target transcripts encoding proteins with known functions in neural differentiation, maturation and disease. We suggest Upf3b-null mice serve as a novel model system to decipher cellular and molecular defects underlying ID and neurodevelopmental disorders
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