10 research outputs found
Inherited Variants in Regulatory T Cell Genes and Outcome of Ovarian Cancer
- Author
- Andrew Berchuck (13724)
- Ann L. Oberg (217897)
- Boris Winterhoff (277815)
- Brooke L. Fridley (93064)
- Catherine M. Phelan (219497)
- Chen Wang (88408)
- Daniel J. Serie (162985)
- David N. Rider (205134)
- Ed Iversen (218136)
- Ellen L. Goode (89912)
- Gottfried Konecny (277821)
- Hannah P. Yang (230756)
- Honglin Song (15103)
- Hugues Sicotte (14304)
- Joellen M. Schildkraut (165651)
- Jonathan Tyrer (89946)
- Julie M. Cunningham (162981)
- Keith L. Knutson (277822)
- Kimberly R. Kalli (254085)
- Kirsten B. Moysich (245994)
- Krista Goergen (277812)
- Kunle Odunsi (122690)
- Lara E. Sucheston (175189)
- Leah Preus (175194)
- Lynn C. Hartmann (254061)
- Matthew J. Maurer (277808)
- Melissa DeRycke (277807)
- Michael J. Birrer (131280)
- Montserrat Garcia-Closas (89866)
- Nicolas Wentzensen (106131)
- Paul P. D. Pharoah (277820)
- Priya Ramar (277810)
- Rachel P. Weber (277817)
- Rebecca Sutphen (238390)
- Robert A. Vierkant (165641)
- Roberta B. Ness (245988)
- Sebastian M. Armasu (277809)
- Shalaka Hampras (277819)
- Simon A. Gayther (205213)
- Susan J. Ramus (205214)
- Thomas A. Sellers (165654)
- Publication venue
- Publication date
- 30/01/2013
- Field of study
<div><p>Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a growing body of data supports the existence of inherited prognostic factors. However, the role of inherited variants in genes encoding Treg-related immune molecules has not been fully explored. We analyzed expression quantitative trait loci (eQTL) and sequence-based tagging single nucleotide polymorphisms (tagSNPs) for 54 genes associated with Tregs in 3,662 invasive ovarian cancer cases. With adjustment for known prognostic factors, suggestive results were observed among rarer histological subtypes; poorer survival was associated with minor alleles at SNPs in RGS1 (clear cell, rs10921202, pâ=â2.7Ă10<sup>â5</sup>), LRRC32 and TNFRSF18/TNFRSF4 (mucinous, rs3781699, pâ=â4.5Ă10<sup>â4</sup>, and rs3753348, pâ=â9.0Ă10<sup>â4</sup>, respectively), and CD80 (endometrioid, rs13071247, pâ=â8.0Ă10<sup>â4</sup>). Fo0r the latter, correlative data support a CD80 rs13071247 genotype association with CD80 tumor RNA expression (pâ=â0.006). An additional eQTL SNP in CD80 was associated with shorter survival (rs7804190, pâ=â8.1Ă10<sup>â4</sup>) among all cases combined. As the products of these genes are known to affect induction, trafficking, or immunosuppressive function of Tregs, these results suggest the need for follow-up phenotypic studies.</p> </div
Regulatory T Cell SNPs Associated with Overall Survival (p<0.001).
- Author
- Andrew Berchuck (13724)
- Ann L. Oberg (217897)
- Boris Winterhoff (277815)
- Brooke L. Fridley (93064)
- Catherine M. Phelan (219497)
- Chen Wang (88408)
- Daniel J. Serie (162985)
- David N. Rider (205134)
- Ed Iversen (218136)
- Ellen L. Goode (89912)
- Gottfried Konecny (277821)
- Hannah P. Yang (230756)
- Honglin Song (15103)
- Hugues Sicotte (14304)
- Joellen M. Schildkraut (165651)
- Jonathan Tyrer (89946)
- Julie M. Cunningham (162981)
- Keith L. Knutson (277822)
- Kimberly R. Kalli (254085)
- Kirsten B. Moysich (245994)
- Krista Goergen (277812)
- Kunle Odunsi (122690)
- Lara E. Sucheston (175189)
- Leah Preus (175194)
- Lynn C. Hartmann (254061)
- Matthew J. Maurer (277808)
- Melissa DeRycke (277807)
- Michael J. Birrer (131280)
- Montserrat Garcia-Closas (89866)
- Nicolas Wentzensen (106131)
- Paul P. D. Pharoah (277820)
- Priya Ramar (277810)
- Rachel P. Weber (277817)
- Rebecca Sutphen (238390)
- Robert A. Vierkant (165641)
- Roberta B. Ness (245988)
- Sebastian M. Armasu (277809)
- Shalaka Hampras (277819)
- Simon A. Gayther (205213)
- Susan J. Ramus (205214)
- Thomas A. Sellers (165654)
- Publication venue
- Publication date
- Field of study
<p>Adjusted for study site (MAY+MAC, RPCI, POL, UKO+UKR, TBO, NCO, RMH, SEA), age at diagnosis (<50 years, 50â69 years, >70 years), tumor stage (I or II, III or IV, unknown), race (white, non-white, unknown), and tumor grade (low, high, unknown); linkage disequilibrium reduced to r<sup>2</sup><0.95; MAF, minor allele frequency.</p
Distributions of Ovarian Cancer Clinical Characteristics by Study.
- Author
- Andrew Berchuck (13724)
- Ann L. Oberg (217897)
- Boris Winterhoff (277815)
- Brooke L. Fridley (93064)
- Catherine M. Phelan (219497)
- Chen Wang (88408)
- Daniel J. Serie (162985)
- David N. Rider (205134)
- Ed Iversen (218136)
- Ellen L. Goode (89912)
- Gottfried Konecny (277821)
- Hannah P. Yang (230756)
- Honglin Song (15103)
- Hugues Sicotte (14304)
- Joellen M. Schildkraut (165651)
- Jonathan Tyrer (89946)
- Julie M. Cunningham (162981)
- Keith L. Knutson (277822)
- Kimberly R. Kalli (254085)
- Kirsten B. Moysich (245994)
- Krista Goergen (277812)
- Kunle Odunsi (122690)
- Lara E. Sucheston (175189)
- Leah Preus (175194)
- Lynn C. Hartmann (254061)
- Matthew J. Maurer (277808)
- Melissa DeRycke (277807)
- Michael J. Birrer (131280)
- Montserrat Garcia-Closas (89866)
- Nicolas Wentzensen (106131)
- Paul P. D. Pharoah (277820)
- Priya Ramar (277810)
- Rachel P. Weber (277817)
- Rebecca Sutphen (238390)
- Robert A. Vierkant (165641)
- Roberta B. Ness (245988)
- Sebastian M. Armasu (277809)
- Shalaka Hampras (277819)
- Simon A. Gayther (205213)
- Susan J. Ramus (205214)
- Thomas A. Sellers (165654)
- Publication venue
- Publication date
- Field of study
<p>Distributions of Ovarian Cancer Clinical Characteristics by Study.</p
<i>CD80</i> rs13071247 Genotype and Tumor Expression.
- Author
- Andrew Berchuck (13724)
- Ann L. Oberg (217897)
- Boris Winterhoff (277815)
- Brooke L. Fridley (93064)
- Catherine M. Phelan (219497)
- Chen Wang (88408)
- Daniel J. Serie (162985)
- David N. Rider (205134)
- Ed Iversen (218136)
- Ellen L. Goode (89912)
- Gottfried Konecny (277821)
- Hannah P. Yang (230756)
- Honglin Song (15103)
- Hugues Sicotte (14304)
- Joellen M. Schildkraut (165651)
- Jonathan Tyrer (89946)
- Julie M. Cunningham (162981)
- Keith L. Knutson (277822)
- Kimberly R. Kalli (254085)
- Kirsten B. Moysich (245994)
- Krista Goergen (277812)
- Kunle Odunsi (122690)
- Lara E. Sucheston (175189)
- Leah Preus (175194)
- Lynn C. Hartmann (254061)
- Matthew J. Maurer (277808)
- Melissa DeRycke (277807)
- Michael J. Birrer (131280)
- Montserrat Garcia-Closas (89866)
- Nicolas Wentzensen (106131)
- Paul P. D. Pharoah (277820)
- Priya Ramar (277810)
- Rachel P. Weber (277817)
- Rebecca Sutphen (238390)
- Robert A. Vierkant (165641)
- Roberta B. Ness (245988)
- Sebastian M. Armasu (277809)
- Shalaka Hampras (277819)
- Simon A. Gayther (205213)
- Susan J. Ramus (205214)
- Thomas A. Sellers (165654)
- Publication venue
- Publication date
- Field of study
<p>Among Nâ=â54 MAY+MAC invasive ovarian cancer cases, Agilent whole human genome 4Ă44 K expression array probe A_24_P155632; CD80 log<sub>2</sub> ratios of tumor versus reference RNA expression (y-axis) versus genotype (x-axis); dashes indicate median; each symbol represents a unique patient; data points are jittered so all data are visible.</p
Seven SNPs show sex difference.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
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a<p>Trait and sex for which the SNP was selected;</p>b<p>Gene labels state the nearest gene or the gene as published previously; details on all genes near the association signal can be found in the <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500.s002" target="_blank">Figure S2</a>;</p>c<p>One-sided P-Values.</p>d<p>larger sample size due to one additional study that did not have hip circumference, and therefore could not contribute to WHRadjBMI.</p>e<p>smaller sample size as this SNP was not on Metabochip.</p><p>Shown are the seven SNPs with significant (at 5% false discovery rate) sex difference in the follow-up data. These seven SNPs exhibit genome-wide significant association in women (joint discovery and follow-up <i>P_women</i><5Ă10â8) and only two of these show nominally significant association in men (joint <i>P_men</i><0.05). The three loci MAP3K1, HSD17B4, and PPARG are shown here for the first time for their anthropometric trait association as well as for sex-difference.</p
Genome-wide scan for sex-specific genome-wide association highlights numerous loci.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
<p>(a) Manhattan plot showing the men-specific (upward, up to 60,586 men) and women-specific (downward, up to 73,137 women) association P-values from the discovery with the 619 selected loci colored by the phenotype for which the locus was selected; (b) QQ-plot showing the sex-specific association P-values as observed against those expected under the null overall phenotypes (black) and for each phenotypes separately (colored).</p
Seven identified SNPs compared to previously published loci.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
a<p>The Effect allele refers to a positive effect direction in the discovery stage for the trait and gender, the SNP was selected for;</p>b<p>Gene near this SNP which was published previously from sex-combined analyses.</p><p>The seven SNPs with sex difference are considered to depict a known locus, if the index SNP is close to a published top SNP (<1 cM). These include four of the previously reported sexually dimorphic WHR loci (Heid et al., Nat Genet 2010).</p
Consistently higher effect sizes for women for all seven loci.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
<p>Shown are beta-estimates and 95% confidence intervals for the seven identified SNPs (also stating the phenotype for which the SNP was selected for).</p
Genome-wide sex-difference scan fails to pinpoint loci.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
<p>(a) Manhattan plot showing sex-difference P-values, (b) QQ plot for sex-difference P-values overall phenotypes (black) and for each phenotype separately (colored).</p
Overview of design and findings.
- Author
- Adam E. Locke (418984)
- Alan R. Shuldiner (110828)
- Albert Hofman (107303)
- Albert Vernon Smith (6608)
- Aldi T. Kraja (418991)
- Alexander Teumer (112757)
- Alistair S. Hall (87549)
- Amy J. Swift (262632)
- Amélie Bonnefond (179465)
- Anders Hamsten (62728)
- Andre Scherag (5655157)
- Andrea Ganna (419008)
- Andrea Maschio (186176)
- Andres Metspalu (61760)
- Andrew A. Hicks (149966)
- Andrew David Morris (419005)
- Andrew R. Wood (149984)
- Andrew Wong (256256)
- André G. Uitterlinden (2213413)
- Anke Tönjes (103703)
- Anna-Liisa Hartikainen (110272)
- Anne U. Jackson (145702)
- Annette Peters (62601)
- Antigone S. Dimas (170915)
- Antony Paul Attwood (418993)
- Antti Jula (37961)
- Anuj Goel (258576)
- Aroon Hingorani (256127)
- Barbara Thorand (44903)
- Ben A. Oostra (122789)
- Bernhard O. Boehm (203595)
- Bernhard R. Winkelmann (237022)
- Brenda Penninx (202064)
- Bruna Gigante (256392)
- Carlo Rivolta (121162)
- Carlos Iribarren (418997)
- Carolina Medina-Gomez (152852)
- Caroline Hayward (149856)
- Caroline S. Fox (110474)
- Cecilia M. Lindgren (145706)
- Chris Power (198703)
- Christa Buechler (418988)
- Christian Gieger (87555)
- Christian Hengstenberg (44258)
- Christina Loley (418992)
- Claes Ohlsson (1924)
- Claudia Lamina (87552)
- Claudia Langenberg (160616)
- Colin N. A. Palmer (157488)
- Cornelia M. van Duijn (103685)
- Cristina Barlassina (136962)
- Damien C. Croteau-Chonka (392540)
- Daniel I. Chasman (120866)
- David Hunter (273536)
- David P. Strachan (110302)
- David Schlessinger (2399)
- Deborah J. Clegg (179176)
- Denise Anderson (125432)
- Devin Absher (217357)
- Diana Kuh (188923)
- Dmitry Shungin (198691)
- Dominique Arveiler (147942)
- Dorret I. Boomsma (109746)
- Elena Tremoli (74641)
- Elina Hyppönen (163747)
- Elizabeth K. Speliotes (145716)
- Emil Rehnberg (223827)
- Emmanouil T. Dermitzakis (120302)
- Erik Ingelsson (232651)
- Eva Albrecht (174584)
- Evelin Mihailov (419003)
- Felix R. Day (418981)
- Fernando Rivadeneira (61551)
- Francis S. Collins (82181)
- Fredrik Karpe (61681)
- Gabrielle Boucher (215508)
- Genovefa Kolovou (419007)
- George Dedoussis (160919)
- George Nicholson (106301)
- Gerjan Navis (111256)
- Gerry Fowkes (38654)
- Giancarlo Cesana (238596)
- Gonçalo R. Abecasis (36598)
- Grant W. Montgomery (131518)
- Gudmar Thorleifsson (156887)
- Guo Li (174860)
- Göran Hallmans (147486)
- H. Erich Wichmann (202082)
- Hanneke Basart (183445)
- Harald Grallert (72666)
- Harold Snieder (103613)
- Harry Campbell (30339)
- Heikki Huikuri (418996)
- Hendrik Sager (419000)
- Henrik Grönberg (122512)
- Henry Völzke (64286)
- Heribert Schunkert (44257)
- Iain Mathieson (113513)
- Ida Surakka (120325)
- Igor Rudan (150101)
- Ilja M. Nolte (238629)
- Inga Prokopenko (43252)
- Inger NjĂžlstad (211908)
- Ingrid B. Borecki (113678)
- InĂȘs Barroso (2144)
- Irene Mateo Leach (128869)
- Iris M. Heid (87553)
- Jaakko Kaprio (43154)
- Jaakko Tuomilehto (65635)
- Jaana Lindström (263654)
- Jackie F. Price (309412)
- Jacques S. Beckmann (149297)
- James F. Wilson (150146)
- Jana V. Van Vliet-Ostaptchouk (4429702)
- Jarmo Virtamo (57860)
- Jeanette Erdmann (44256)
- Jeffrey R. O'Connell (170220)
- Jennie Hui (220409)
- Jennifer G. Sambrook (108247)
- Jennifer Jolley (108251)
- Jennifer L. Bolton (383129)
- Jian Yang (12136)
- Jian'an Luan (2145)
- Jianxin Shi (90453)
- Jing Hua Zhao (73808)
- Joel N. Hirschhorn (131545)
- Johan G. Eriksson (150122)
- Johanna Kuusisto (197767)
- John P. Beilby (418999)
- John W. G. Yarnell (95276)
- Jon P. Krohn (418986)
- Jonathan Tyrer (89946)
- Joseph Hung (418994)
- Joshua C. Randall (145712)
- Josine L. Min (181837)
- Jouke-Jan Hottenga (75574)
- Jouko Saramies (392555)
- Juha Sinisalo (418995)
- Kaarel KrjutĂ ÂĄkov (419002)
- Karen L. Mohlke (143380)
- Kari E. North (68131)
- Kari Kuulasmaa (62541)
- Kari Stefansson (26484)
- Karol Estrada (149937)
- Kathleen Stirrups (145729)
- Kati Kristiansson (149853)
- Kay-Tee Khaw (110271)
- Kees G. Hovingh (418998)
- Ken K. Ong (188600)
- Keri L. Monda (198707)
- Kevin B. Jacobs (160321)
- Krista Fischer (45881)
- Kristian Hveem (189996)
- Kristina Eisinger (418989)
- L. Adrienne Cupples (113601)
- Lambertus A. Kiemeney (160926)
- Lars Lind (88400)
- Leif C. Groop (198713)
- Liming Liang (69800)
- Lindsay L. Waite (392538)
- Lori L. Bonnycastle (262574)
- Lu Qi (160573)
- Lyle J. Palmer (95287)
- Lynda M. Rose (225264)
- M. Carola Zillikens (152896)
- Marcus E. Kleber (106276)
- Maria Dimitriou (160853)
- Maris Teder-Laving (418990)
- Marja-Liisa Lokki (156903)
- Marjo-Riitta Jarvelin (110290)
- Mark I. McCarthy (145748)
- Mark J. Caulfield (238657)
- Markku Laakso (197777)
- Markus M. Nöthen (160934)
- Markus Perola (62544)
- Martin den Heijer (24963)
- Martin Farrall (62715)
- Martina MĂŒller-Nurasyid (193464)
- Mary F. Feitosa (198679)
- Massimo Mangino (87550)
- Matti Uusitupa (89892)
- Mattias Lorentzon (121092)
- Meena Kumari (95278)
- Melanie M. Van der Klauw (5655160)
- Michael A. Province (53600)
- Michael Boehnke (145750)
- Mika Kivimaki (2222011)
- Mustafa Atalay (198682)
- Najaf Amin (114329)
- Nancy L. Heard-Costa (262573)
- Nancy L. Pedersen (123123)
- Narisu Narisu (262622)
- Nicholas G. Martin (113568)
- Nicholas J. Wareham (110277)
- Niina Eklund (149841)
- Nilesh J. Samani (60118)
- Olli Raitakari (144269)
- Pablo V. Gejman (171372)
- Panos Deloukas (21564)
- Patricia B. Munroe (145744)
- Patrik K. E. Magnusson (123143)
- Paul M. Ridker (191917)
- Paul W. Franks (136032)
- Per Hall (23544)
- Peter E. H. Schwarz (261982)
- Peter Kovacs (103720)
- Peter P. Pramstaller (150111)
- Peter S. Chines (145692)
- Philippe Froguel (2247)
- Pim van der Harst (65060)
- Raimund Erbel (49439)
- Rainer Rauramaa (211915)
- Reedik MĂ€gi (667294)
- Robert Kaplan (419010)
- Rona J. Strawbridge (419006)
- Ross M. Fraser (419001)
- Ruth J. F. Loos (110224)
- Sabrina Bauer (418987)
- Sailaja Vedantam (131467)
- Samuli Ripatti (144251)
- Sarah E. Medland (127141)
- Sarah Edkins (203067)
- Sekar Kathiresan (60585)
- Shengxu Li (180928)
- Sirkka M. Keinanen-Kiukaanniemi (5655163)
- Sonali Pechlivanis (282952)
- Sonja I. Berndt (202053)
- Stavroula Kanoni (160847)
- Stefan Gustafsson (418983)
- Stefan R. Bornstein (114705)
- Stephan J. L. Bakker (111215)
- Stephen J. Chanock (14311)
- Steve E. Humphries (142616)
- Susanne Moebus (15191)
- Talin Haritunians (262584)
- Tamara B. Harris (110195)
- Teresa Ferreira (418982)
- Terho LehtimÀki (49739)
- Themistocles L. Assimes (111675)
- Thomas Illig (44906)
- Thomas Person (418985)
- Thomas W. Winkler (174716)
- Tim D. Spector (108990)
- Timo A. Lakka (198694)
- Timo E. Saaristo (419004)
- Timothy Frayling (419009)
- Toby Johnson (43283)
- Tom Wilsgaard (321883)
- Tove Fall (201258)
- Tsegaselassie Workalemahu (315947)
- Tuomas O. KilpelÀinen (145704)
- TÔnu Esko (102379)
- Ulf de Faire (256395)
- Ulf Gyllensten (13773)
- Unnur Thorsteinsdottir (49155)
- Valgerdur Steinthorsdottir (160577)
- Veikko Salomaa (62543)
- Wendy L. McArdle (110155)
- Winfried MĂ€rz (106288)
- Wolfgang Koenig (26222)
- Yii-Der Ida Chen (113593)
- Zhaoming Wang (50224)
- ZoltĂĄn Kutalik (174641)
- Ă sa Johansson (84687)
- Publication venue
- Publication date
- Field of study
<p>Among the 7 identified loci, we defined those close to (<1 cM) published hits <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500-LangoAllen1" target="_blank">[25]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500-Speliotes1" target="_blank">[29]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003500#pgen.1003500-Heid1" target="_blank">[31]</a> as <i>near published hit</i>s and <i>novel</i> otherwise. Novel loci with sex-combined discovery P-value<5.8Ă10<sup>â5</sup>, which is the P-value cut-off corresponding to 5% FDR, were declared as loci that <i>could have been discovered also with sex-combined analysis</i>, and otherwise that these <i>would have been missed without the sex-stratified analyses</i>. FDRâ=âfalse discovery rate.</p