The Footprint of F-theory at the LHC

Recent work has shown that compactifications of F-theory provide a potentially attractive phenomenological scenario. The low energy characteristics of F-theory GUTs consist of a deformation away from a minimal gauge mediation scenario with a high messenger scale. The soft scalar masses of the theory are all shifted by a stringy effect which survives to low energies. This effect can range from 0 GeV up to ~ 500 GeV. In this paper we study potential collider signatures of F-theory GUTs, focussing in particular on ways to distinguish this class of models from other theories with an MSSM spectrum. To accomplish this, we have adapted the general footprint method developed recently for distinguishing broad classes of string vacua to the specific case of F-theory GUTs. We show that with only 5 fb^(-1) of simulated LHC data, it is possible to distinguish many mSUGRA models and low messenger scale gauge mediation models from F-theory GUTs. Moreover, we find that at 5 fb^(-1), the stringy deformation away from minimal gauge mediation produces observable consequences which can also be detected to a level of order ~ +/- 80 GeV. In this way, it is possible to distinguish between models with a large and small stringy deformation. At 50 fb^(-1), this improves to ~ +/- 10 GeV.Comment: 85 pages, 37 figure

Characterization of Retinal Structure in ATF6-Associated Achromatopsia.

PurposeMutations in six genes have been associated with achromatopsia (ACHM): CNGA3, CNGB3, PDE6H, PDE6C, GNAT2, and ATF6. ATF6 is the most recent gene to be identified, though thorough phenotyping of this genetic subtype is lacking. Here, we sought to test the hypothesis that ATF6-associated ACHM is a structurally distinct form of congenital ACHM.MethodsSeven genetically confirmed subjects from five nonconsanguineous families were recruited. Foveal hypoplasia and the integrity of the ellipsoid zone (EZ) band (a.k.a., IS/OS) were graded from optical coherence tomography (OCT) images. Images of the photoreceptor mosaic were acquired using confocal and nonconfocal split-detection adaptive optics scanning light ophthalmoscopy (AOSLO). Parafoveal cone and rod density values were calculated and compared to published normative data as well as data from two subjects harboring CNGA3 or CNGB3 mutations who were recruited for comparative purposes. Additionally, nonconfocal dark-field AOSLO images of the retinal pigment epithelium were obtained, with quantitative analysis performed in one subject with ATF6-ACHM.ResultsFoveal hypoplasia was observed in all subjects with ATF6 mutations. Absence of the EZ band within the foveal region (grade 3) or appearance of a hyporeflective zone (grade 4) was seen in all subjects with ATF6 using OCT. There was no evidence of remnant foveal cone structure using confocal AOSLO, although sporadic cone-like structures were seen in nonconfocal split-detection AOSLO. There was a lack of cone structure in the parafovea, in direct contrast to previous reports.ConclusionsOur data demonstrate a near absence of cone structure in subjects harboring ATF6 mutations. This implicates ATF6 as having a major role in cone development and suggests that at least a subset of subjects with ATF6-ACHM have markedly fewer cellular targets for cone-directed gene therapies than do subjects with CNGA3- or CNGB3-ACHM

The thermal emission of the exoplanets WASP-1b and WASP-2b

We present a comparative study of the thermal emission of the transiting exoplanets WASP-1b and WASP-2b using the Spitzer Space Telescope. The two planets have very similar masses but suffer different levels of irradiation and are predicted to fall either side of a sharp transition between planets with and without hot stratospheres. WASP-1b is one of the most highly irradiated planets studied to date. We measure planet/star contrast ratios in all four of the IRAC bands for both planets (3.6-8.0um), and our results indicate the presence of a strong temperature inversion in the atmosphere of WASP-1b, particularly apparent at 8um, and no inversion in WASP-2b. In both cases the measured eclipse depths favor models in which incident energy is not redistributed efficiently from the day side to the night side of the planet. We fit the Spitzer light curves simultaneously with the best available radial velocity curves and transit photometry in order to provide updated measurements of system parameters. We do not find significant eccentricity in the orbit of either planet, suggesting that the inflated radius of WASP-1b is unlikely to be the result of tidal heating. Finally, by plotting ratios of secondary eclipse depths at 8um and 4.5um against irradiation for all available planets, we find evidence for a sharp transition in the emission spectra of hot Jupiters at an irradiation level of 2 x 10^9 erg/s/cm^2. We suggest this transition may be due to the presence of TiO in the upper atmospheres of the most strongly irradiated hot Jupiters.Comment: 10 pages, submitted to Ap

Solar System Physics for Exoplanet Research

Over the past three decades, we have witnessed one of the great revolutions in our understanding of the cosmos-the dawn of the Exoplanet Era. Where once we knew of just one planetary system (the solar system), we now know of thousands, with new systems being announced on a weekly basis. Of the thousands of planetary systems we have found to date, however, there is only one that we can study up-close and personal-the solar system. In this review, we describe our current understanding of the solar system for the exoplanetary science community-with a focus on the processes thought to have shaped the system we see today. In section one, we introduce the solar system as a single well studied example of the many planetary systems now observed. In section two, we describe the solar system's small body populations as we know them today-from the two hundred and five known planetary satellites to the various populations of small bodies that serve as a reminder of the system's formation and early evolution. In section three, we consider our current knowledge of the solar system's planets, as physical bodies. In section four we discuss the research that has been carried out into the solar system's formation and evolution, with a focus on the information gleaned as a result of detailed studies of the system's small body populations. In section five, we discuss our current knowledge of planetary systems beyond our own-both in terms of the planets they host, and in terms of the debris that we observe orbiting their host stars. As we learn ever more about the diversity and ubiquity of other planetary systems, our solar system will remain the key touchstone that facilitates our understanding and modeling of those newly found systems, and we finish section five with a discussion of the future surveys that will further expand that knowledge

Focus Points and Naturalness in Supersymmetry

We analyze focus points in supersymmetric theories, where a parameter's renormalization group trajectories meet for a family of ultraviolet boundary conditions. We show that in a class of models including minimal supergravity, the up-type Higgs mass has a focus point at the weak scale, where its value is highly insensitive to the universal scalar mass. As a result, scalar masses as large as 2 to 3 TeV are consistent with naturalness, and {\em all} squarks, sleptons and heavy Higgs scalars may be beyond the discovery reaches of the Large Hadron Collider and proposed linear colliders. Gaugino and Higgsino masses are, however, still constrained to be near the weak scale. The focus point behavior is remarkably robust, holding for both moderate and large \tan\beta, any weak scale gaugino masses and A parameters, variations in the top quark mass within experimental bounds, and for large variations in the boundary condition scale.Comment: 30 pages, 17 figure

Zebrafish Mutants calamity and catastrophe Define Critical Pathways of Gene–Nutrient Interactions in Developmental Copper Metabolism

Nutrient availability is an important environmental variable during development that has significant effects on the metabolism, health, and viability of an organism. To understand these interactions for the nutrient copper, we used a chemical genetic screen for zebrafish mutants sensitive to developmental copper deficiency. In this screen, we isolated two mutants that define subtleties of copper metabolism. The first contains a viable hypomorphic allele of atp7a and results in a loss of pigmentation when exposed to mild nutritional copper deficiency. This mutant displays incompletely penetrant skeletal defects affected by developmental copper availability. The second carries an inactivating mutation in the vacuolar ATPase that causes punctate melanocytes and embryonic lethality. This mutant, catastrophe, is sensitive to copper deprivation revealing overlap between ion metabolic pathways. Together, the two mutants illustrate the utility of chemical genetic screens in zebrafish to elucidate the interaction of nutrient availability and genetic polymorphisms in cellular metabolism

Exoplanet Diversity in the Era of Space-based Direct Imaging Missions

This whitepaper discusses the diversity of exoplanets that could be detected by future observations, so that comparative exoplanetology can be performed in the upcoming era of large space-based flagship missions. The primary focus will be on characterizing Earth-like worlds around Sun-like stars. However, we will also be able to characterize companion planets in the system simultaneously. This will not only provide a contextual picture with regards to our Solar system, but also presents a unique opportunity to observe size dependent planetary atmospheres at different orbital distances. We propose a preliminary scheme based on chemical behavior of gases and condensates in a planet's atmosphere that classifies them with respect to planetary radius and incident stellar flux.Comment: A white paper submitted to the National Academy of Sciences Exoplanet Science Strateg

Altered Retinoic Acid Metabolism in Diabetic Mouse Kidney Identified by 18O Isotopic Labeling and 2D Mass Spectrometry

Numerous metabolic pathways have been implicated in diabetes-induced renal injury, yet few studies have utilized unbiased systems biology approaches for mapping the interconnectivity of diabetes-dysregulated proteins that are involved. We utilized a global, quantitative, differential proteomic approach to identify a novel retinoic acid hub in renal cortical protein networks dysregulated by type 2 diabetes.Total proteins were extracted from renal cortex of control and db/db mice at 20 weeks of age (after 12 weeks of hyperglycemia in the diabetic mice). Following trypsinization, (18)O- and (16)O-labeled control and diabetic peptides, respectively, were pooled and separated by two dimensional liquid chromatography (strong cation exchange creating 60 fractions further separated by nano-HPLC), followed by peptide identification and quantification using mass spectrometry. Proteomic analysis identified 53 proteins with fold change >or=1.5 and p<or=0.05 after Benjamini-Hochberg adjustment (out of 1,806 proteins identified), including alcohol dehydrogenase (ADH) and retinaldehyde dehydrogenase (RALDH1/ALDH1A1). Ingenuity Pathway Analysis identified altered retinoic acid as a key signaling hub that was altered in the diabetic renal cortical proteome. Western blotting and real-time PCR confirmed diabetes-induced upregulation of RALDH1, which was localized by immunofluorescence predominantly to the proximal tubule in the diabetic renal cortex, while PCR confirmed the downregulation of ADH identified with mass spectrometry. Despite increased renal cortical tissue levels of retinol and RALDH1 in db/db versus control mice, all-trans-retinoic acid was significantly decreased in association with a significant decrease in PPARbeta/delta mRNA.Our results indicate that retinoic acid metabolism is significantly dysregulated in diabetic kidneys, and suggest that a shift in all-trans-retinoic acid metabolism is a novel feature in type 2 diabetic renal disease. Our observations provide novel insights into potential links between altered lipid metabolism and other gene networks controlled by retinoic acid in the diabetic kidney, and demonstrate the utility of using systems biology to gain new insights into diabetic nephropathy