Polyglot Semantic Parsing in APIs

Traditional approaches to semantic parsing (SP) work by training individual models for each available parallel dataset of text-meaning pairs. In this paper, we explore the idea of polyglot semantic translation, or learning semantic parsing models that are trained on multiple datasets and natural languages. In particular, we focus on translating text to code signature representations using the software component datasets of Richardson and Kuhn (2017a,b). The advantage of such models is that they can be used for parsing a wide variety of input natural languages and output programming languages, or mixed input languages, using a single unified model. To facilitate modeling of this type, we develop a novel graph-based decoding framework that achieves state-of-the-art performance on the above datasets, and apply this method to two other benchmark SP tasks.Comment: accepted for NAACL-2018 (camera ready version

Uncertainty of flow in porous media

The problem posed to the Study Group was, in essence, how to estimate the probability distribution of f(x) from the probability distribution of x. Here x is a large vector and f is a complicated function which can be expensive to evaluate. For Schlumberger's applications f is a computer simulator of a hydrocarbon reservoir, and x is a description of the geology of the reservoir, which is uncertain

An Index of Child Well-being in the European Union

While the living conditions of children and young people in the European Union have gained increasing recognition across the EU, the well-being of children is not monitored on the European level. Based on a rights-based, multi-dimensional understanding of child well-being we analyse data already available for the EU 25, using series data as well as comparative surveys of children and young people. We compare the performance of EU Member States on eight clusters with 23 domains and 51 indicators and give a picture of children’s overall well-being in the European Union. The clusters are children’s material situation, housing, health, subjective well-being, education, children’s relationships, civic participation and risk and safety

Towards the ‘Big Society’: What role for neighbourhood working? Evidence from a comparative European study

Under the New Labour government, the neighbourhood emerged prominently as a site for policy interventions and as a space for civic activity, resulting in the widespread establishment of neighbourhood-level structures for decision-making and service delivery. The future existence and utility of these arrangements is now unclear under the Coalition government's Big Society proposals and fiscal austerity measures. On the one hand, sub-local governance structures might be seen as promoting central-to-local and local-to-community devolution of decision-making. On the other, they might be seen as layers of expensive bureaucracy standing in the way of bottom-up community action. Arguably the current value and future role of these structures in facilitating the Big Society will depend on how they are constituted and with what purpose. There are many local variations. In this paper we look at three case studies, in England, France and the Netherlands, to learn how different approaches to neighbourhood working have facilitated and constrained civic participation and action. Drawing on the work of Lowndes and Sullivan (2008) we show how the achievement of civic objectives can be hampered in structures set up primarily to achieve social, economic and political goals, partly because of (remediable) flaws in civic engagement but partly because of the inherent tensions between these objectives in relation to issues of spatial scale and the constitution and function of neighbourhood structures. The purpose of neighbourhood structures needs to be clearly thought through. We also note a distinction between 'invited' and 'popular' spaces for citizen involvement, the latter being created by citizens themselves. 'Invited' spaces have tended to dominate to date, and the Coalition's agenda suggests a fundamental shift to 'popular' spaces. However we conclude that the Big Society will require neighbourhood working to be both invited and popular. Citizen participation cannot always replace local government - sometimes it requires its support and stimulation. The challenge for local authorities is to reconstitute 'invited' spaces (not to abolish them) and at the same time to facilitate 'popular' spaces for neighbourhood working.Big Society, local government, neighbourhood, neighbourhood management, community

The Halo Occupation Distribution of X-ray-Bright Active Galactic Nuclei: A Comparison with Luminous Quasars

We perform halo occupation distribution (HOD) modeling of the projected two-point correlation function (2PCF) of high-redshift (z~1.2) X-ray-bright active galactic nuclei (AGN) in the XMM-COSMOS field measured by Allevato et al. The HOD parameterization is based on low-luminosity AGN in cosmological simulations. At the median redshift of z~1.2, we derive a median mass of (1.02+0.21/-0.23)x10^{13} Msun/h for halos hosting central AGN and an upper limit of ~10% on the AGN satellite fraction. Our modeling results indicate (at the 2.5-sigma level) that X-ray AGN reside in more massive halos compared to more bolometrically luminous, optically-selected quasars at similar redshift. The modeling also yields constraints on the duty cycle of the X-ray AGN, and we find that at z~1.2 the average duration of the X-ray AGN phase is two orders of magnitude longer than that of the quasar phase. Our inferred mean occupation function of X-ray AGN is similar to recent empirical measurements with a group catalog and suggests that AGN halo occupancy increases with increasing halo mass. We project the XMM-COSMOS 2PCF measurements to forecast the required survey parameters needed in future AGN clustering studies to enable higher precision HOD constraints and determinations of key physical parameters like the satellite fraction and duty cycle. We find that N^{2}/A~5x10^{6} deg^{-2} (with N the number of AGN in a survey area of A deg^{2}) is sufficient to constrain the HOD parameters at the 10% level, which is easily achievable by upcoming and proposed X-ray surveys.Comment: 11 pages, 4 figures, accepted in Ap

Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible

The aminophospholipid phosphatidylserine (PS) is normally restricted to the inner leaflet of the plasma membrane. During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied annexin V, a calcium-dependent PS-binding protein. In mouse cochlear cultures, annexin V labeling reveals that the aminoglycoside antibiotic neomycin induces rapid PS externalization, specifically on the apical surface of hair cells. PS externalization is observed within ~75 s of neomycin perfusion, first on the hair bundle and then on membrane blebs forming around the apical surface. Whole-cell capacitance also increases significantly within minutes of neomycin application, indicating that blebbing is accompanied by membrane addition to the hair cell surface. PS externalization and membrane blebbing can, nonetheless, occur independently. Pretreating hair cells with calcium chelators, a procedure that blocks mechanotransduction, or overexpressing a phosphatidylinositol 4,5-biphosphate (PIP2)-binding pleckstrin homology domain, can reduce neomycin-induced PS externalization, suggesting that neomycin enters hair cells via transduction channels, clusters PIP2, and thereby activates lipid scrambling. The effects of short-term neomycin treatment are reversible. After neomycin washout, PS is no longer detected on the apical surface, apical membrane blebs disappear, and surface-bound annexin V is internalized, distributing throughout the supranuclear cytoplasm of the hair cell. Hair cells can therefore repair, and recover from, neomycin-induced surface damage. Hair cells lacking myosin VI, a minus-end directed actin-based motor implicated in endocytosis, can also recover from brief neomycin treatment. Internalized annexin V, however, remains below the apical surface, thereby pinpointing a critical role for myosin VI in the transport of endocytosed material away from the periphery of the hair cell

Protecting mammalian hair cells from aminoglycoside-toxicity: assessing phenoxybenzamine’s potential

Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic,causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or discovering agents that protect against aminoglycoside ototoxicity have focused on inhibiting apoptosis or more recently, on preventing antibiotic uptake by the hair cells. Recent screens for ototoprotective compounds using the larval zebrafish lateral line identified phenoxybenzamine as a potential protectant for aminoglycoside induced hair cell death. Here we used live imaging of FM1-43 uptake as a proxy for aminoglycoside entry, combined with hair-cell death assays to evaluate whether phenoxybenzamine can protect mammalian cochlear hair cells from the deleterious effects of the aminoglycoside antibiotic neomycin. We show that phenoxybenzamine can block FM1-43 entry into mammalian hair cells in a reversible and dose-dependent manner, but pre-incubation is required for maximal inhibition of entry. We observed differential effects of phenoxybenzamine on FM1-43 uptake in the two different types of cochlear hair cell in mammals, the outer hair cells (OHCs) and inner hair cells (IHCs).The requirement for pre-incubation and reversibility suggests an intracellular rather than an extracellular site of action for phenoxybenzamine. We also tested the efficacy of phenoxybenzamine as an otoprotective agent. In mouse cochlear explants the hair cell death resulting from 24 h exposure to neomycin was steeply dose-dependent, with 50% cell death occurring at ~230 uM for both IHC and OHC. We used 250 uM neomycin in subsequent hair-cell death assays. At 100 uM with 1 h pre-incubation, phenoxybenzamine conferred significant protection to both IHCs and OHCs, however at higher concentrations phenoxybenzamine itself showed clear signs of ototoxicity and an additive toxic effect when combined with neomycin. These data do not support the use of phenoxybenzamine as a therapeutic agent in mammalian inner ear. Our findings do share parallels with the observations from the zebrafish lateral line model but they also highlight the necessity for validation in the mammalian system and the potential for differential effects on sensory hair cells from different species, in different systems and even between cells in the same organ