Polygenic risk scores for elevated CRP level and protective effect on schizophrenia, using individual-level genetic data.

<p>Polygenic risk scores for elevated CRP level and protective effect on schizophrenia, using individual-level genetic data.</p

The effect of the CRP genetic risk score instrument of 18 SNPs associated with CRP (GRS_<i>GWAS</i>) on somatic and neuropsychiatric outcomes after correcting for heterogeneity.

<p>The effect of the CRP genetic risk score instrument of 18 SNPs associated with CRP (GRS_<i>GWAS</i>) on somatic and neuropsychiatric outcomes after correcting for heterogeneity.</p

Genetic risk score GRS_<i>GWAS</i> for bipolar disorder.

<p>The <i>x-</i>axis shows the effect size for the 18 SNPs comprising the GRS_<i>GWAS</i> influencing levels of CRP, with corresponding standard error bars. The <i>y-</i>axis shows the log OR of the GRS_<i>GWAS</i> SNPs for bipolar disorder (BIP) with corresponding standard error bars. The effect estimate of CRP level on disease risk is represented by the red solid line, with gradient α. The 95% CI of this α estimate is represented by the grey dashed lines. The included SNPs are shown by Arabic numbering: #1, rs2847281 (gene: <i>PTPN2</i>; chromosome: 18; basepair position: 12811593); #2, rs340029 (<i>RORA</i>; 15; 58682257); #3, rs6901250 (<i>GPRC6A</i>; 6; 117220718); #4, rs10745954 (<i>ASCL1</i>; 12; 102007224); #5, rs4705952(<i>IRF1</i>; 5; 131867517); #6, rs12037222 (<i>PABPC4</i>; 1; 39837548); #7, rs12239046 (<i>NLRP3</i>; 1; 245668218); #8, rs6734238 (<i>IL1F10</i>; 2; 113557501); #9, rs13233571 (<i>BCL7B</i>; 7; 72609167); #10, rs9987289 (<i>PPP1R3B</i>; 8; 9220768); #11, rs1260326 (<i>GCKR</i>; 2; 27584444); #12, rs4129267 (<i>IL6R</i>; 1; 152692888); #13, rs1800961 (<i>HNF4A</i>; 20; 42475778); #14, rs4420065 (<i>LEPR</i>; 1; 5934049); #15, rs10521222 (<i>SALL1</i>; 16; 49716211); #16, rs1183910 (<i>HNF1A</i>; 12; 119905190); #17, rs2794520 (<i>CRP</i>; 1; 157945440); #18, rs4420638 (<i>APOC1</i>; 19; 50114786).</p

Genetic risk score GRS_<i>GWAS</i> for schizophrenia.

<p>The <i>x-</i>axis shows the effect size for the 15 SNPs for which data were available in the PGC schizophrenia dataset comprising the GRS_<i>GWAS</i> influencing levels of CRP, with corresponding standard error bars. The <i>y-</i>axis shows the log OR of the GRS_<i>GWAS</i> SNPs for schizophrenia (SCZ) with corresponding standard error bars. The effect estimate of CRP level on disease risk is represented by the red solid line, with gradient α. The 95% CI of this α estimate is represented by the grey dashed lines. The included SNPs are shown by Arabic numbering: #1, rs2847281 (gene: <i>PTPN2</i>; chromosome: 18; basepair position: 12811593); #2, rs340029 (<i>RORA</i>; 15; 58682257); #3, rs6901250 (<i>GPRC6A</i>; 6; 117220718); #4, rs10745954 (<i>ASCL1</i>; 12; 102007224); #5, rs4705952 (<i>IRF1</i>; 5; 131867517); #6, rs12037222 (<i>PABPC4</i>; 1; 39837548); #7, rs12239046 (<i>NLRP3</i>; 1; 245668218); #8, rs6734238 (<i>IL1F10</i>; 2; 113557501); #9, rs13233571 (<i>BCL7B</i>; 7; 72609167); #11, rs1260326 (<i>GCKR</i>; 2; 27584444); #12, rs4129267 (<i>IL6R</i>; 1; 152692888); #13, rs1800961 (<i>HNF4A</i>; 20; 42475778); #14, rs4420065 (<i>LEPR</i>; 1; 5934049); #15, rs10521222 (<i>SALL1</i>; 16; 49716211); 12; 119905190); #17, rs2794520 (<i>CRP</i>; 1; 157945440). The three SNPs of #10, rs9987289 (<i>PPP1R3B</i>; 8; 9220768); #16, rs1183910 (<i>HNF1A</i>; and #18, rs4420638 (<i>APOC1</i>; 19; 50114786) were not present in the data of the PGC.</p

The effect of the CRP genetic risk score instrument of 18 SNPs associated with CRP (GRS_<i>GWAS</i>) on somatic and neuropsychiatric outcomes.

<p>The effect of the CRP genetic risk score instrument of 18 SNPs associated with CRP (GRS_<i>GWAS</i>) on somatic and neuropsychiatric outcomes.</p

Polygenic risk scores for elevated CRP level and explained variance of schizophrenia using individual-level genetic data.

<p>Polygenic risk scores for elevated CRP level and explained variance of schizophrenia using individual-level genetic data.</p

The effect of the CRP genetic risk score instrument of four SNPs in CRP (GRS_<i>CRP</i>) with somatic and neuropsychiatric outcomes.

<p>The effect of the CRP genetic risk score instrument of four SNPs in CRP (GRS_<i>CRP</i>) with somatic and neuropsychiatric outcomes.</p

Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.

<p>Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.</p

Additional novel BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in sex-stratified analyses of African ancestry discovery and replication samples.

<p>Additional novel BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in sex-stratified analyses of African ancestry discovery and replication samples.</p