A Parametric Modeling Approach to Measuring the Gas Masses of Circumstellar Disks

The disks that surround young stars are mostly composed of molecular gas, which is harder to detect and interpret than the accompanying dust. Disk mass measurements have therefore relied on large and uncertain extrapolations from the dust to the gas. We have developed a grid of models to study the dependencies of isotopologue CO line strengths on disk structure and temperature parameters and find that a combination of 13CO and C18O observations provides a robust measure of the gas mass. We apply this technique to Submillimeter Array observations of nine circumstellar disks and published measurements of six well studied disks. We find evidence for selective photodissociation of C18O and determine masses to within a factor of about three. The inferred masses for the nine disks in our survey range from 0.7-6 M_Jup, and all are well below the extrapolation from the interstellar medium gas-to-dust ratio of 100. This is consistent with the low masses of planets found around such stars, and may be due to accretion or photoevaporation of a dust-poor upper atmosphere. However, the masses may be underestimated if there are more efficient CO depletion pathways than those known in molecular clouds and cold cores.Comment: Accepted for publication in the ApJ. 15 pages, 11 figures, full model grid (Table 3) available in the source file

Is Student Knowledge of Anatomy Affected by a Problem-Based Learning Approach? A Review

A fundamental understanding of anatomy is critical for students on many health science courses. It has been suggested that a problem-based approach to learning anatomy may result in deficits in foundation knowledge. The aim of this review is to compare traditional didactic methods with problem-based learning methods for obtaining anatomy knowledge. A Medline search was completed and studies needed to investigate the effects of a problem-based learning method compared with an alternate method with the primary outcome being examination scores to be included. Ten articles matched the inclusion criteria. Most studies investigated undergraduate medical students. Four studies demonstrated improved exam results following a problem-based learning approach and five demonstrated no difference between didactic and problem-based learning. Overall a problem-based approach appears not to offer disadvantages or benefits over a more traditional didactic approach, however it has been suggested that additional skills, such as problem solving may be developed when using this approach

A study of methanol and silicon monoxide production through episodic explosions of grain mantles in the Central Molecular Zone

Methanol (CH$_3$OH) is found to be abundant and widespread towards the Central Molecular Zone, the inner few hundred parsecs of our Galaxy. Its origin is, however, not fully understood. It was proposed that the high cosmic ray ionisation rate in this region could lead to a more efficient non-thermal desorption of this species formed on grain surfaces, but it would also mean that this species is destroyed in a relatively short timescale. In a first step, we run chemical models with a high cosmic ray ionisation rate and find that this scenario can only reproduce the lowest abundances of methanol derived in this region ($\sim$10$^{-9}$-10$^{-8}$). In a second step, we investigate another scenario based on episodic explosions of grain mantles. We find a good agreement between the predicted abundances of methanol and the observations. We find that the dominant route for the formation of methanol is through hydrogenation of CO on the grains followed by the desorption due to the grain mantle explosion. The cyclic aspect of this model can explain the widespread presence of methanol without requiring any additional mechanism. We also model silicon monoxide (SiO), another species detected in several molecular clouds of the Galactic Centre. An agreement is found with observations for a high depletion of Si (Si/H $\sim$ 10$^{-8}$) with respect to the solar abundance.Comment: Accepted in MNRA

Champagne Flutes and Brandy Snifters: Modelling Protostellar Outflow-Cloud Chemical Interfaces

A rich variety of molecular species has now been observed towards hot cores in star forming regions and in the interstellar medium. An increasing body of evidence from millimetre interferometers suggests that many of these form at the interfaces between protostellar outflows and their natal molecular clouds. However, current models have remained unable to explain the origin of the observational bias towards wide-angled "brandy snifter" shaped outflows over narrower "champagne flute" shapes in carbon monoxide imaging. Furthermore, these wide-angled systems exhibit unusually high abundances of the molecular ion HCO$^+$. We present results from a chemo-dynamic model of such regions where a rich chemistry arises naturally as a result of turbulent mixing between cold, dense molecular gas and the hot, ionized outflow material. The injecta drives a rich and rapid ion-neutral chemistry in qualitative and quantitative agreement with the observations. The observational bias towards wide-angled outflows is explained naturally by the geometry-dependent ion injection rate causing rapid dissociation of CO in the younger systems.Comment: Accepted to MNRAS. 12 pages, 8 Figure

The Dust Properties of Eight Debris Disk Candidates as Determined by Submillimeter Photometry

The nature of far-infrared dust emission toward main sequence stars, whether interstellar or circumstellar, can be deduced from submillimeter photometry. We present JCMT/SCUBA flux measurements at 850 microns toward 8 stars with large photospheric excesses at 60-100 microns. 5 sources were detected at 3-sigma or greater significance and one was marginally detected at 2.5-sigma. The inferred dust masses and temperatures range from 0.033 to 0.24 Earth masses and 43-65 K respectively. The frequency behavior of the opacity, tau_nu ~ nu^beta, is relatively shallow, beta < 1. These dust properties are characteristic of circumstellar material, most likely the debris from planetesimal collisions. The 2 non-detections have lower temperatures, 35-38 K and steeper opacity indices, beta > 1.5, that are more typical of interstellar cirrus. The confirmed disks all have inferred diameters > 2'', most lie near the upper envelope of the debris disk mass distribution, and 4 are bright enough to be feasible for high resolution imaging.Comment: accepted by Ap

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development

In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnidarian model to study the origins of TLR signaling because its genome encodes a single TLR and homologs of many downstream signaling components, including the NF-κB pathway. We have characterized the single N. vectensis TLR (Nv-TLR) and demonstrated that it can activate canonical NF-κB signaling in human cells. Furthermore, we show that the intracellular Toll/IL-1 receptor (TIR) domain of Nv-TLR can interact with the human TLR adapter proteins MAL and MYD88. We demonstrate that the coral pathogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated V. coralliilyticus and bacterial flagellin can activate a reconstituted Nv-TLR–to–NF-κB pathway in human cells. By immunostaining of anemones, we show that Nv-TLR is expressed in a subset of cnidocytes and that many of these Nv-TLR–expressing cells also express Nv-NF-κB. Additionally, the nematosome, which is a Nematostella-specific multicellular structure, expresses Nv-TLR and many innate immune pathway homologs and can engulf V. coralliilyticus. Morpholino knockdown indicates that Nv-TLR also has an essential role during early embryonic development. Our characterization of this primitive TLR and identification of a bacterial pathogen for N. vectensis reveal ancient TLR functions and provide a model for studying the molecular basis of cnidarian disease and immunity.IOS-1354935 - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); GRFP - National Science Foundation (NSF); 1262934 - National Science Foundation (NSF); 2014-BSP - Arnold and Mabel Beckman Foundatio

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease.

While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated. We used targeted adeno-associated viral vector (AAV) overexpression of human mutant α-synuclein (A53T) in the rat substantia nigra (SN) to produce degeneration of SN dopamine neurons, loss of striatal dopamine levels, and behavioral impairment. Some animals received daily GM1 ganglioside administration for 6 weeks, beginning 24 hours after AAV-A53T administration or delayed start GM1 administration for 5 weeks beginning 3 weeks after AAV-A53T administration. Both types of GM1 administration protected against loss of SN dopamine neurons and striatal dopamine levels, reduced α-synuclein aggregation, and delayed start administration of GM1 reversed early appearing behavioral deficits. These results extend prior positive results in MPTP models, are consistent with the results of a small clinical study of GM1 in PD patients that showed slowing of symptom progression with chronic use, and argue for the continued refinement and development of GM1 as a potential disease modifying therapy for PD