Tools for automated acoustic monitoring within the R package monitoR

<p>The R package monitoR contains tools for managing an acoustic-monitoring program including survey metadata, template creation and manipulation, automated detection and results management. These tools are scalable for use with small projects as well as larger long-term projects and those with expansive spatial extents. Here, we describe typical workflow when using the tools in monitoR. Typical workflow utilizes a generic sequence of functions, with the option for either binary point matching or spectrogram cross-correlation detectors.</p

Effect of Drug Holiday on CSF Drug Levels.

<p>Predictive illustration of the effect of “drug holidays” at steady-state. Drug holiday began at the arrow (24 hours). Dosing then resumed as usual at 72 hours. Despite the holiday, CSF levels remained above 1 micromolar in the 4 gm/day group, and fell slightly below 1 micromolar in the 2 gm/day group.</p

Enrollment, Randomization, Follow-Up and Analysis.

<p>Enrollment, Randomization, Follow-Up and Analysis.</p

Time to Discontinuation of Study Drug by Treatment Arm (until 20 weeks).

<p>Kaplan-Meyer curve showing time to discontinuation of study drug within the first 20 weeks for patients who discontinued study drug within this time frame. Time to discontinuation of study drug was not significantly different between treatment arms (p = 0.90; Log-Rank). LD – Low Dose Ceftriaxone Arm; HD - High Dose Ceftriaxone Arm.</p

Serious Adverse Events.

<p>Serious Adverse Events.</p

Demographics.

<p>VC – Vital Capacity; HHD - Hand-Held Dynamometry; ALSFRS-R – Revised ALS Functional Rating Scale; ALSQOL – ALS Quality of Life Questionnaire; V_d – Volume of Distribution; T_1/2– Half-life; mL – milliliters; min – minutes; kg - kilograms.</p

Reasons for Drug Discontinuation in Stages 1 and 2.

*<p>Pseudomembranous colitis, Pruritis, Neutropenia.</p>**<p>Pulmonary edema, Cholelithiasis.</p

Cholelithiasis and Biliary Sludging by Treatment Arm.

<p>(a) Biliary sludging and cholelithiasis were more common in the low dose (LD) and high dose (HD) treatment arms than in the placebo treatment arm (p<0.01; Jonckheere-Terpstra). (b) Treatment with ursodiol significantly shortened event duration when used to treat cholelithiasis and biliary sludging (p,0.001; Log-Rank).</p