Average relationship between incretin effect and incretin hormones.

<p>Relationship between the incretin effect on total insulin secretion and the corresponding mean OGTT plasma GLP-1 and GIP in NGT and T2D participants. Plots are mean±SE.</p

Incretin effect on potentiation.

<p>Time-course of the incretin effect on OGTT/IIGI ratio of the potentiation factor with increasing glucose loads in NGT and T2D participants. The potentiation factor is normalized to the baseline value before calculating the ratio. Plots are mean±SE.</p

Statistical significance of differences by test, dose, and group (ANOVA for doubly repeated measures)^*.

*<p>Test = OGTT <i>vs</i> IIGT; Dose = 25 <i>vs</i> 75 <i>vs</i> 125 g of glucose orally; Group = NGT <i>vs</i> T2D.</p

Incremental insulin secretion response to intravenous and oral glucose.

<p>Individual trajectories for the relationship between the dose-dependent increment above basal in total insulin secretion during the OGTT and the IIGI in NGT and T2D participants. The dotted lines are the identity line.</p

Individual relationships between incretin effect and incretin hormones.

<p>Individual trajectories for the relationship between the incretin effect on total insulin secretion and the mean OGTT/IIGI ratio of GLP-1 and GIP concentrations in NGT and T2D participants.</p