Absolute and relative active time per day in patients with ILD, COPD and healthy controls.

Distribution of active periods (METs level ≥1.5) in a day, expressed as the amount of active minutes per two hours (panel A) and the relative distribution of a patient’s active time over the day during waking hours (7AM to 9PM) (panel B) in patients with ILD, COPD and healthy controls.</p

Example of a physical activity report of one day.

Example of a physical activity report of one day, measured by SenseWear Pro armband. Mean intensity (METs) during waking hours: mean energy expenditure expressed in metabolic equivalent of a task between 7AM until 10PM. Mean intensity (METs) when active: mean energy expenditure expressed in METs when METs level of 1.5 is exceeded. MVPA bout ≥2’: period of at least two minutes when METs level ≥3. Total time MVPA per day is the summation of these periods in one day. MVPA bout ≥2’ is also used to calculate the mean duration of a MVPA bout. MVPA bout ≥10’: period of at least 10 minutes when METS level ≥3.</p

Correlations between daily steps and clinical characteristics.

BMI: body mass index; FEV1: forced expiratory volume in the first second; FVC: forced vital capacity; DLCO: diffusion capacity for carbon monoxide; 6MWD: six-minute walking distance; QF: quadriceps force. r: Pearson correlation coefficient; p: p-value. (DOCX)</p

Characteristics for ILD, COPD and healthy controls before and after propensity matching analysis.

Characteristics for ILD, COPD and healthy controls before and after propensity matching analysis.</p

Physical activity characteristics of patients with ILD, COPD and healthy controls.

Physical activity characteristics of patients with ILD, COPD and healthy controls.</p

Diagnosis of ILD patients, n (%).

IIP: idiopathic interstitial pneumonias; IPF: idiopathic pulmonary fibrosis; INSIP: idiopathic nonspecific interstitial pneumonia; COP: cryptogenic organizing pneumonia; IIP: idiopathic interstitial pneumonias; EAA: extrinsic allergic alveolitis; CTD-ILD: connective tissue disease-associated interstitial lung disease. (DOCX)</p

Patient characterization after propensity matching analysis.

Patient characterization after propensity matching analysis.</p

Characteristics for ILD group for matched and unmatched patients.

Results shown as mean ± standard error of the mean. M/F: male/female; %M: percentage of males in the sample; BMI: body mass index; 6MWD: six-minute walking distance. P-value for comparison between ILD matched and unmatched population. (DOCX)</p

Correlation between functional exercise capacity and physical activity in patients with ILD, COPD and healthy controls.

Correlation between six-minute walking distance (x-axis) and daily steps (y-axis) in patients with ILD (black dots), COPD (grey dots) and healthy controls (open squares). *P<0.05.</p

Kaplan-Meier survival curve of the placebo and the montelukast arm at 2 years.

<p>Kaplan-Meier survival curve of the placebo and the montelukast arm at 2 years.</p