29 research outputs found
Managing at source and at scale: The use of geomorphic river stories to support rehabilitation of Anthropocene riverscapes in the East Coast Region of Aotearoa New Zealand
Recently uplifted, highly erodible rocks, and recurrent high intensity storms, generate exceedingly high erosion and sedimentation rates in the East Coast Region (Tairāwhiti) of Aotearoa New Zealand. Despite the recent nature of the Anthropocene record in global terms (∼650 years since Māori arrival, 250 years of colonial impacts), human disturbance has profoundly altered evolutionary trajectories of river systems across the region. Here we document catchment-by-catchment variability in anthropogenic signature as geomorphic river stories for five catchments (Waiapu, Hikuwai, Waimatā, Waipaoa, Mōtū). We show how targeted, fit-for-purpose process-based rehabilitation programmes that manage at source and at scale are required to facilitate river recovery in each of these catchments. The largest rivers in the region, Waiapu and Waipaoa, comprise steep, highly dissected terrains that are subject to recurrent hillslope failures, including systemic shallow landslides, occasional deep-seated rotational slumps and earthflows. Localised sediment input from large (>10 ha) gully mass movement complexes overwhelms valley floors. Targeted revegetation programmes are required to reduce extreme sediment inputs from these sources. Although there are fewer gully complexes in the Hikuwai, multiple landslips supply vast volumes of fine-grained sediment that aggrade and are recurrently reworked along channel margins in lowland reaches. Waimatā has no gully complexes and a smaller number of landslips, but large areas are subject to sediment input from earthflows. The terrace-constrained flume-like nature of this system efficiently flushes materials ‘from the mountains to the sea’, recurrently reworking materials along channel banks in a similar manner to the lower Hikuwai. Systematic reforestation in the middle-upper catchment and revegetation of riparian corridors is required to reduce sedimentation rates in these catchments. In contrast, terraces buffer sediment delivery from hillslopes in the upper Mōtū catchment, where a bedrock gorge separates large sediment stores along upper reaches from the lower catchment. As reworking of valley floor sediments in response to bed incision and reworking (expansion) of channel margins is the primary contemporary sediment source in this system, bed control structures and revegetation of riparian corridors are required as part of targeted sediment management plans. We contend that geomorphic river stories provide a coherent platform for Anthropocene rehabilitation strategies that work with the character, behaviour and evolutionary trajectories of river systems. Although this generic lens can be applied anywhere in the world, we highlight particular meanings and implications in Aotearoa New Zealand where such thinking aligns directly with Māori values that respect the mana (authority), mauri (lifeforce) and ora (wellbeing) of each and every river
Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial):A Multicentre, Randomised, Controlled Trial
RationaleMesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in COVID-19-related Acute Respiratory Distress Syndrome (ARDS).ObjectivesWe investigated safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) in COVID-related ARDS.MethodsThis multicentre, randomised, double-blind, allocation concealed, placebo-controlled trial (NCT03042143) randomised patients with moderate-to-severe COVID-related ARDS to receive ORBCEL-C (400million cells) or placebo (Plasma-Lyte148).MeasurementsThe primary safety and efficacy outcomes were incidence of serious adverse events and oxygenation index at day 7 respectively. Secondary outcomes included respiratory compliance, driving pressure, PaO2/FiO2 ratio and SOFA score. Clinical outcomes relating to duration of ventilation, length of intensive care unit and hospital stays, and mortality were collected. Long-term follow up included diagnosis of interstitial lung disease at 1 year, and significant medical events and mortality at 2 years. Transcriptomic analysis was performed on whole blood at day 0, 4 and 7.Main results60 participants were recruited (final analysis n=30 ORBCEL-C, n=29 placebo: 1 in placebo group withdrew consent). 6 serious adverse events occurred in the ORBCEL-C and 3 in the placebo group, RR 2.9(0.6-13.2)p=0.25. Day 7 mean[SD] oxygenation index did not differ (ORBCEL-C 98.357.2], placebo 96.667.3). There were no differences in secondary surrogate outcomes, nor mortality at day 28, day 90, 1 or 2 years. There was no difference in prevalence of interstitial lung disease at 1year nor significant medical events up to 2 years. ORBCEL-C modulated the peripheral blood transcriptome.ConclusionORBCEL-C MSCs were safe in moderate-to-severe COVID-related ARDS, but did not improve surrogates of pulmonary organ dysfunction. Clinical trial registration available at www.Clinicaltrialsgov, ID: NCT03042143. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/)
Holocene sedimentary history of Chilliwack Valley, Northern Cascade Mountains
I seek to reconstruct the balance between sediment storage and yield across multiple drainage basin scales in a large (1 230 km2) watershed in the Northern Cascade range, British Columbia and Washington. Chilliwack Valley and surrounding area has been the site of numerous studies that have detailed much of its Quaternary sedimentary history. In the present study this information is supplemented by reconstruction of the morphodynamic trajectory of the river valley though the Holocene Epoch, and development of a sediment transfer model that describes the relaxation from the Fraser glaciation. The total Holocene sediment yield is estimated from basins across several scales using field and remotely sensed evidence to constrain the historical mass balance of delivery to higher order tributary basins. Rates of hillslope erosion are estimated using a diffusion-based relation for open slopes and delimitating the volume evacuated from major gully sources. Digital terrain models of paleo-surfaces are constructed to calculate total sediment erosion and deposition from tributary valleys and the mainstem. Chilliwack Lake has effectively trapped the entire post-glacial sediment load from the upper catchment (area = 334 km2), allowing to compare this "nested" system with the larger catchment. Rates of lake sediment accumulation are estimated using sediment cores and paleomagnetism. These are compared with accumulation rates in the terminal fan inferred from radiocarbon dating of fossil material, obtained by sonic drilling in the apex gravels. A sediment budget framework is then used to summarize the net transfer of weathered material and glacial sediments from the hillslope scale to the mainstem. The long-term average sediment yield from the upper basin is 62 +/- 9 t/km2/yr; contemporary yield is approximately 30 t/km2/yr. It is found that only 10-15% of the material eroded from the hillslopes is delivered to mouths of the major tributaries; the remaining material is stored at the base of footslopes and within the fluvial sedimentary system. Since the retreat of Fraser Ice from the mouth of the valley, Chilliwack River delivered over 1.8 +/- 0.21 km3 of gravel and sand to Vedder Fan in the Fraser Valley. In the sediment budget developed here, roughly 85% of that material is attributed to glacial sources, notably the Ryder Uplands and glacial valley fills deposited along the mainstem, upstream of Tamihi Creek. In tributary valleys, local base-level has fallen, leading to the evacuation of deep glacial sedimentary fills. Many of the lower reaches of major tributaries in upper Chilliwack Valley (e.g. Centre and Nesakwatch Creeks) remain primarily sediment sinks for slope-derived inputs, since base-level fall has not been initiated. In distal tributaries (Liumchen, Tamihi and Slesse creeks), paraglacial fans have been incised or completely eroded, entrained by laterally active channels. A transition from transport-limited to supply-limited conditions has been effected in many of these reaches. Slesse Creek has struck an intermediate balance, as it continues to remobilize its considerable sediment stores. It functions today as the sedimentary headwaters of Chilliwack Valley. Using grain size data and fine-sediment geochemical data gathered from Chilliwack River over the course of several field seasons, a simple finite-difference, surface-based sediment transport model is proposed. The aim of the model is to integrate the sediment-balance information, as inferred from estimates of hillslope erosion and valley storage, and physical principles of sediment transport dynamics to reproduce the key characteristics of a system undergoing base-level fall and reworking its considerable valley fill during degradation. Such characteristics include the river long profile, the river grain-size fining gradient, the percentage of substrate sand, and the diminution of headwater granite lithology in the active load. The model is able to reproduce many of the characteristics, but is not able to satisfy all criteria simultaneously. There is inevitably some ambiguity as to the set of parameters that produce the "right" result, however the model provides good insight into long-term interactions among parameters such as dominant discharge, grain size specifications, abrasion rates, initial topography, hiding functions, and hydraulic parameters.Arts, Faculty ofGeography, Department ofGraduat
Effects of a large woody debris accumulation on channel-bed morphology during flood events
A novel experimental setup for the laboratory was designed in order to investigate large woody debris accumulations and their influence on hydraulic flow conditions and channel morphology at a river cross-section. Real wood and mobile gravel bedload material were used to simulate morphodynamic interactions in a headwater stream, based on a New Zealand prototype river. The survey methodology employs Structure from Motion techniques, using an advanced multi-camera-array. In this study we present the experimental setup and initial results from our first experiments. With this research project we aim to investigate the dynamics of jam initiation and the characteristic evolution of the jam, for a given discharge, sediment load, and distribution of woody material. Furthermore, this study will elaborate more practical and efficient methodologies for observing wood jams, both in the laboratory and in the field. The project expands current knowledge about interaction processes between flow, sediment and woody debris, which are presently poorly understood and still represent a gap in research
Effects of a large woody debris accumulation on channel-bed morphology during flood events
A novel experimental setup for the laboratory was designed in order to investigate large woody debris accumulations and their influence on hydraulic flow conditions and channel morphology at a river cross-section. Real wood and mobile gravel bedload material were used to simulate morphodynamic interactions in a headwater stream, based on a New Zealand prototype river. The survey methodology employs Structure from Motion techniques, using an advanced multi-camera-array. In this study we present the experimental setup and initial results from our first experiments. With this research project we aim to investigate the dynamics of jam initiation and the characteristic evolution of the jam, for a given discharge, sediment load, and distribution of woody material. Furthermore, this study will elaborate more practical and efficient methodologies for observing wood jams, both in the laboratory and in the field. The project expands current knowledge about interaction processes between flow, sediment and woody debris, which are presently poorly understood and still represent a gap in research
Measuring the impact: new insights into flood-borne large wood collisions with river structures using an isolated sensor-unit
Large Wood (LW) transported during floods or channelized mass flows poses a high risk for engineered structures, often leading to significant damage or total failure of the impacted structure. To date little is known about impact magnitudes caused by LW collisions. To better control for such interactions, a better understanding of transport dynamics and impact forces is required. The present laboratory study employs state-of-the-art sensor units installed in scaled logs to capture acceleration data from collisions of waterborne LW with 2 in-stream structures-bridge pier and retention structure-each providing different examples of rigid engineered systems. Through precise measurements of acceleration and impact duration (stopping time), the resultant impact forces of LW collisions can be calculated. Here, for the first time, impact forces were quantified in a scaled stream environment based on the inertial frame of the object causing the impact, rather than the more commonly used instrumented structure approach. High-resolution accelerometer measurements were compared to conventional analytical (force balance) approaches. They revealed the need for accurate inertia measurements to appropriately account for prevailing hydraulic flow conditions and the effects of LW interactions in fluvial environments. Although log velocity and stopping time are crucial parameters for assessing LW impact forces, accurate measurements are still elusive due to limitations in available sensing techniques. By presenting proof-of-concept results, this study contributes to an improved understanding of LW impact forces during floods. Based on these encouraging results, we recommend more sensor-based field studies in future, needed for the design of resilient structures.ISSN:0921-030XISSN:1573-084
Fabrication of a nanoparticle gradient substrate by thermochemical manipulation of an ester functionalized SAM
The hydrolysis of methyl ester (–CO2Me) and tert-butyl ester (–CO2tBu) functionalized SAMs as a function of subphase temperature and pH is described. Contact angle measurements show that the methyl ester functionalized monolayer does not hydrolyse in pH 1–13 aqueous solutions heated up to 80 °C. In contrast, the –CO2tBu functionalized monolayer hydrolysed below pH 5. The rate and the extent of the hydrolysis were dependent on the temperature and pH of the aqueous solution. Using the Cassie equation, the activation energy for the hydrolysis of CO2tBu-phenyl functionalized SAM was determined as 75 ± 7 kJ mol−1 from the contact angle measurements. Furthermore, the adhesion properties of –CO2tBu and –COOH functionalized SAMs were investigated by depositing –NR2 and –COOH functionalized polystyrene nanoparticles onto the surfaces at pH 3 and 9. By AFM, it was observed that the particles bind preferentially to the –COOH functionalized SAM and the adhesion was pH dependent, with the largest coverage being observed at pH 3. Using the acquired understanding of the hydrolysis of –CO2tBu functionalized SAM and the particle adhesion properties, a simple and facile approach towards fabricating a particle density gradient on this surface is demonstrated. An acid gradient SAM (20 mm long) was prepared by mounting one end of a –CO2tBu functionalized SAM onto the hot side of a Peltier element (80 °C) in pH 1 aqueous solution. The substrate was subsequently immersed into a colloidal solution of –NR2 functionalized polystyrene nanoparticles, removed and rinsed. By AFM, the particle density was shown to be dependent on the surface coverage of –COOH moieties of the underlying SAM. The density started at 104 particles μm−2 on the hydrolysed end down to 0 particles μm−2 on the non-hydrolysed end