Disrupted autophagy undermines skeletal muscle adaptation and integrity

This review assesses the importance of proteostasis in skeletal muscle maintenance with a specific emphasis on autophagy. Skeletal muscle appears to be particularly vulnerable to genetic defects in basal and induced autophagy, indicating that autophagy is co-substantial to skeletal muscle maintenance and adaptation. We discuss emerging evidence that tension-induced protein unfolding may act as a direct link between mechanical stress and autophagic pathways. Mechanistic links between protein damage, autophagy and muscle hypertrophy, which is also induced by mechanical stress, are still poorly understood. However, some mouse models of muscle disease show ameliorated symptoms upon effective targeting of basal autophagy. These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders

Large-group psychodynamics and massive violence Psicodinâmica da violência de grandes grupos e da violência de massas

Beginning with Freud, psychoanalytic theories concerning large groups have mainly focused on individuals' perceptions of what their large groups psychologically mean to them. This chapter examines some aspects of large-group psychology in its own right and studies psychodynamics of ethnic, national, religious or ideological groups, the membership of which originates in childhood. I will compare the mourning process in individuals with the mourning process in large groups to illustrate why we need to study large-group psychology as a subject in itself. As part of this discussion I will also describe signs and symptoms of large-group regression. When there is a threat against a large-group's identity, massive violence may be initiated and this violence in turn, has an obvious impact on public health.<br>A partir de Freud, as teorias psicanalíticas a respeito de grandes grupos focalizam principalmente as percepções e os significados que os indivíduos psicologicamente atribuem a eles. Este texto analisa alguns aspectos sobre a psicologia dos grandes grupos e sua psicodinâmica interna e específica. Toma como referência grupos étnicos, nacionais, religiosos e ideológicos cujo pertencimento dos sujeitos iniciou-se na infância. Faz-se uma comparação entre o processo de luto em indivíduos e o processo de luto em grandes grupos para ilustrar por que é necessário investir no conhecimento da psicologia destes últimos, como um objeto específico. Descreve ainda sinais e sintomas de regressão em grandes grupos. Quando há ameaça à identidade coletiva pode ocorrer um processo de violência de massas que obviamente influencia na sua saúde coletiva