Design, synthesis and characterization of novel fluorinated styryl chromones

225-228(E)-3-(3-(Trifluoromethyl)-5-nitrophenyl)acrylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with acetic acid in HCl gives 5. The structures of all synthesized compounds have been confirmed by spectroscopic techniques

Design, synthesis and characterization of novel fluorinated styryl chromones

(E)-3-(3-(Trifluoromethyl)-5-nitrophenyl)acrylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with acetic acid in HCl gives 5. The structures of all synthesized compounds have been confirmed by spectroscopic techniques