Still waters run deep: latent cytokine activity in nonlesional psoriasis skin

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116968/1/bjd14248_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/116968/2/bjd14248.pd

Early tissue responses in psoriasis to the antitumour necrosis factor‐α biologic etanercept suggest reduced interleukin‐17 receptor expression and signalling

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108076/1/bjd12937-sup-0005-TableS2.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/108076/2/bjd12937-sup-0004-TableS1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/108076/3/bjd12937.pd

Flat Information Geometries in Black Hole Thermodynamics

The Hessian of either the entropy or the energy function can be regarded as a metric on a Gibbs surface. For two parameter families of asymptotically flat black holes in arbitrary dimension one or the other of these metrics are flat, and the state space is a flat wedge. The mathematical reason for this is traced back to the scale invariance of the Einstein-Maxwell equations. The picture of state space that we obtain makes some properties such as the occurence of divergent specific heats transparent.Comment: 14 pages, one figure. Dedicated to Rafael Sorkin's birthda

Review of LLNS Contractor Assurance System (CAS)

The focus of the review was to evaluate the LLNS Contractor Assurance System (CAS) system description document and implementation plan. The team reviewed the description document and the near and long term strategy improvement plans for the defined enhancements to the LLNS CAS. Review emphasis was placed on the CAS functional elements of Assessments, Issues Management, and Performance Measures, as well as the related CAS attributes of Requirements, Policies and Procedures, Risk Methodology, and Continuous Improvement. The approach taken by the team was to review the pertinent LLNL CAS documents, interview key CAS Process Owners, and interview selected line managers. The reviews were conducted in such a manner to achieve an understanding of the overall objective of the CAS and the processes within; and the soundness of the improvement plans for each of the elements/related attributes. The team then identified suggested recommendations for consideration as the overall implementation process for improvements move forward. The team appreciates the work that went into the development of the CAS Implementation Plan. It provided a meaningful starting place for this AIM team as it included sufficient information to quickly gain an understanding of the current LANS CAS processes and improvement initiatives. The team found that the July 2007 CAS Description Document did not provide a level of detail which would provide the reader an understanding of the elements and attributes of the CAS, how they are integrated, and how they help Managers manage the performance of their activities. Consider revising the document to include a level of detail that would provide value to the LLNS Board of Governors, LSO, and LLNL Managers. The team also found the description document to focus almost exclusively on describing the LLNS approach and initiatives associated with the 17 key attributes of Contract Clause H-4. While these discussions are appropriate for inclusion in the description document, by themselves, they do not clearly address the requirements and criteria in Attachment 1 and Appendix A to DOE 226.1A. It would seem that a comprehensive written CAS description document would address not only the expectations of Clause H-4, but that it would also address the requirements and criteria from DOE O 226.1A

'Reclaiming the criminal' : the role and training of prison officers in England, 1877-1914

This article examines the role and training of prison officers in England, between 1877 and 1914. It is concerned with the changing penal philosophies and practices of this period and how these were implemented in local prisons, and the duties of the prison officer. More broadly, this article argues that the role of the prison officer and their training (from 1896) reflect wider ambiguities in prison policy and practice during this period

Finding Faint Intermediate-mass Black Holes in the Radio Band

We discuss the prospects for detecting faint intermediate-mass black holes, such as those predicted to exist in the cores of globular clusters and dwarf spheroidal galaxies. We briefly summarize the difficulties of stellar dynamical searches, then show that recently discovered relations between black hole mass, X-ray luminosity and radio luminosity imply that in most cases, these black holes should be more easily detected in the radio than in the X-rays. Finally, we show upper limits from some radio observations of globular clusters, and discuss the possibility that the radio source in the core of the Ursa Minor dwarf spheroidal galaxy might be a $\sim 10,000-100,000 M_\odot$ black hole.Comment: 10 pages, no figures, to appear in From X-ray Binaries to Quasars: Black Hole Accretion on All Mass Scales, ed. T. J. Maccarone, R. P. Fender, and L. C. Ho (Dordrecht: Kluwer

Incipient Separation in Shock Wave Boundary Layer Interactions as Induced by Sharp Fin

The incipient separation induced by the shock wave turbulent boundary layer interaction at the sharp fin is the subject of present study. Existing theories for the prediction of incipient separation, such as those put forward by McCabe (1966) and Dou and Deng (1992), can have thus far only predicting the direction of surface streamline and tend to over-predict the incipient separation condition based on the Stanbrook's criterion. In this paper, the incipient separation is firstly predicted with Dou and Deng (1992)'s theory and then compared with Lu and Settles (1990)' experimental data. The physical mechanism of the incipient separation as induced by the shock wave/turbulent boundary layer interactions at sharp fin is explained via the surface flow pattern analysis. Furthermore, the reason for the observed discrepancy between the predicted and experimental incipient separation conditions is clarified. It is found that when the wall limiting streamlines behind the shock wave becomes\ aligning with one ray from the virtual origin as the strength of shock wave increases, the incipient separation line is formed at which the wall limiting streamline becomes perpendicular to the local pressure gradient. The formation of this incipient separation line is the beginning of the separation process. The effects of Reynolds number and the Mach number on incipient separation are also discussed. Finally, a correlation for the correction of the incipient separation angle as predicted by the theory is also given.Comment: 34 pages; 9 figure

The Magnificent Seven: Magnetic fields and surface temperature distributions

Presently seven nearby radio-quiet isolated neutron stars discovered in ROSAT data and characterized by thermal X-ray spectra are known. They exhibit very similar properties and despite intensive searches their number remained constant since 2001 which led to their name ``The Magnificent Seven''. Five of the stars exhibit pulsations in their X-ray flux with periods in the range of 3.4 s to 11.4 s. XMM-Newton observations revealed broad absorption lines in the X-ray spectra which are interpreted as cyclotron resonance absorption lines by protons or heavy ions and / or atomic transitions shifted to X-ray energies by strong magnetic fields of the order of 10^13 G. New XMM-Newton observations indicate more complex X-ray spectra with multiple absorption lines. Pulse-phase spectroscopy of the best studied pulsars RX J0720.4-3125 and RBS 1223 reveals variations in derived emission temperature and absorption line depth with pulse phase. Moreover, RX J0720.4-3125 shows long-term spectral changes which are interpreted as due to free precession of the neutron star. Modeling of the pulse profiles of RX J0720.4-3125 and RBS 1223 provides information about the surface temperature distribution of the neutron stars indicating hot polar caps which have different temperatures, different sizes and are probably not located in antipodal positions.Comment: 10 pages, 8 figures, to appear in Astrophysics and Space Science, in the proceedings of "Isolated Neutron Stars: from the Interior to the Surface", edited by D. Page, R. Turolla and S. Zan