10,519 research outputs found
Adaptation and readaptation medical concerns of a Mars trip
The ability of the human body to adapt to microgravity environments and to later readapt to a gravity environment was examined. Issues specifically relating to the effects of long duration space flight on the adaptation/readaptation process are discussed. The need for better health prediction techniques is stressed in order to be able to better anticipate crew health problems and to perform corrective actions. Several specific examples are discussed of latent diseases which could occur during a long duration space mission, even after having subjected the crew to thorough premission checkups. The need for learning how to prevent or ameliorate such problems as space adaptation syndrome, bone and muscle (and possibly tissue) atrophy, immune system atrophy, and heart arrythmias is also discussed. The implications of the age of the crew, the influence of an onboard low level gravity field, and drugs are briefly addressed as factors in the adaptation/readaptation process
First Class Call Stacks: Exploring Head Reduction
Weak-head normalization is inconsistent with functional extensionality in the
call-by-name -calculus. We explore this problem from a new angle via
the conflict between extensionality and effects. Leveraging ideas from work on
the -calculus with control, we derive and justify alternative
operational semantics and a sequence of abstract machines for performing head
reduction. Head reduction avoids the problems with weak-head reduction and
extensionality, while our operational semantics and associated abstract
machines show us how to retain weak-head reduction's ease of implementation.Comment: In Proceedings WoC 2015, arXiv:1606.0583
Enabling open science for health research: Collaborative Informatics Environment for Learning on Health Outcomes (CIELO)
Effects of Weightlessness on Human Fluid and Electrolyte Physiology
The changes that occur in human fluid and electrolyte physiology during the acute and adaptive phases of adaptation to spaceflight are summarized. A number of questions remain to be answered. At a time when plasma volume and extracellular fluid volume are contracted and salt and water intake is unrestricted. ADH does not correct the volume deficit and serum sodium decreases. Change in secretion or activity of a natriuretic factor during spaceflight is one possible explanation. Recent identification of a polypeptide hormone produced in cardiac muscle cells which is natiuretic, is hypotensive, and has an inhibitory effect on renin and aldosterone secretion has renewed interest in the role of a natriuretic factor. The role of this atrial natriuretic factor (ANF) in both long- and short-term variation in extracellular volumes and in the inability of the kidney to bring about an escape from the sodium-retaining state accompanying chronic cardiac dysfunction makes it reasonable to look for a role of ANF in the regulation of sodium during exposure to microgravity. Prostaglandin-E is another hormone that may antagonize the action of ADH. Assays of these hormones will be performed on samples from crew members in the future
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