8,782 research outputs found
Fragility of iron-based glasses
The viscosity of various iron-based bulk-glass-forming liquids is measured around the glass transition, and the associated fragility is calculated. Fragility is found to vary broadly between compositions, from a low value of ~43, which indicates fairly “strong” liquid behavior, to ~65, well within the region of “fragile” behavior. Despite a strong covalent bonding identified in the structure of this class of metal/metalloid glasses, their liquid fragility can be remarkably high, exceeding even the very fragile palladium and platinum bulk-glass formers. An inverse correlation between glass-forming ability and fragility is identified, suggesting that iron-based glasses are effectively “kinetically” stabilized
Evidence of unexplained discrepancies between planned and conducted statistical analyses: a review of randomized trials
Evidence of unexplained discrepancies between planned and conducted statistical analyses: a review of randomised trial
Quantifying the origin of metallic glass formation
The waiting time to form a crystal in a unit volume of homogeneous undercooled liquid exhibits a pronounced minimum τ_X* at a ‘nose temperature’ T* located between the glass transition temperature T_g, and the crystal melting temperature, T_L. Turnbull argued that τ_X* should increase rapidly with the dimensionless ratio t_(rg)=T_g/T_L. Angell introduced a dimensionless ‘fragility parameter’, m, to characterize the fall of atomic mobility with temperature above T_g. Both t_(rg) and m are widely thought to play a significant role in determining τ_X*. Here we survey and assess reported data for T_L, T_g, t_(rg), m and τ_X* for a broad range of metallic glasses with widely varying τ_X*. By analysing this database, we derive a simple empirical expression for τ_X*(t_(rg), m) that depends exponentially on t_(rg) and m, and two fitting parameters. A statistical analysis shows that knowledge of t_(rg) and m alone is therefore sufficient to predict τ_X* within estimated experimental errors. Surprisingly, the liquid/crystal interfacial free energy does not appear in this expression for τ_X*
Remote vibrotactile noise improves light touch sensation in stroke survivors’ fingertips via stochastic resonance
Observation of an apparent first-order glass transition in ultrafragile Pt–Cu–P bulk metallic glasses
An experimental study of the configurational thermodynamics for a series of near-eutectic Pt_(80-x)Cu_xP₂₀ bulk metallic glass-forming alloys is reported where 14 < x < 27. The undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in an increasingly sharp glass transition. With decreasing x, the extrapolated Kauzmann temperature of the liquid, T_K, becomes indistinguishable from the conventionally defined glass transition temperature, T_g. For x < 17, the observed liquid configurational enthalpy vs. T displays a marked discontinuous drop or latent heat at a well-defined freezing temperature, T_(gm). The entropy drop for this first-order liquid/glass transition is approximately two-thirds of the entropy of fusion of the crystallized eutectic alloy. Below T_(gm), the configurational entropy of the frozen glass continues to fall rapidly, approaching that of the crystallized eutectic solid in the low T limit. The so-called Kauzmann paradox, with negative liquid entropy (vs. the crystalline state), is averted and the liquid configurational entropy appears to comply with the third law of thermodynamics. Despite their ultrafragile character, the liquids at x = 14 and 16 are bulk glass formers, yielding fully glassy rods up to 2- and 3-mm diameter on water quenching in thin-wall silica tubes. The low Cu content alloys are definitive examples of glasses that exhibit first-order melting
Phonon-Induced Topological Transition to a Type-II Weyl Semimetal
Given the importance of crystal symmetry for the emergence of topological
quantum states, we have studied, as exemplified in NbNiTe2, the interplay of
crystal symmetry, atomic displacements (lattice vibration), band degeneracy,
and band topology. For NbNiTe2 structure in space group 53 (Pmna) - having an
inversion center arising from two glide planes and one mirror plane with a
2-fold rotation and screw axis - a full gap opening exists between two band
manifolds near the Fermi energy. Upon atomic displacements by optical phonons,
the symmetry lowers to space group 28 (Pma2), eliminating one glide plane along
c, the associated rotation and screw axis, and the inversion center. As a
result, twenty Weyl points emerge, including four type-II Weyl points in the
G-X direction at the boundary between a pair of adjacent electron and hole
bands. Thus, optical phonons may offer control of the transition to a Weyl
fermion state
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IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown. We found inactivating mutations and homologous or hemizygous deletions in the CHUK locus, which encodes IKKα, in human lung ADCs. The CHUK deletions significantly reduced the survival time of patients with lung ADCs harboring KRAS mutations. In mice, lung-specific Ikkα ablation (IkkαΔLu ) induces spontaneous ADCs and promotes KrasG12D-initiated ADC development, accompanied by increased cell proliferation, decreased cell senescence, and reactive oxygen species (ROS) accumulation. IKKα deletion up-regulates NOX2 and down-regulates NRF2, leading to ROS accumulation and blockade of cell senescence induction, which together accelerate ADC development. Pharmacologic inhibition of NADPH oxidase or ROS impairs KrasG12D-mediated ADC development in IkkαΔLu mice. Therefore, IKKα modulates lung ADC development by controlling redox regulatory pathways. This study demonstrates that IKKα functions as a suppressor of lung ADC in human and mice through a unique mechanism that regulates tumor cell-associated ROS metabolism
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