A comparison of anterior and posterior chamber lenses after cataract extraction in rural Africa: a within patient randomised trial.

BACKGROUND: Extracapsular cataract extraction (ECCE) with a posterior chamber intraocular lens (PC IOL) is the preferred method of cataract surgery in developed countries. However, intracapsular cataract extraction (ICCE) with an anterior chamber lens (AC IOL) may be appropriate in rural Africa. A randomised controlled trial was carried out to compare these surgical strategies. METHODS: Participants over 50 years requiring bilateral cataract surgery were recruited from outreach clinics in rural north and east Uganda. One eye was randomly allocated to AC IOL or PC IOL, the other eye being allocated to the second strategy. The main outcome measure was WHO distance visual acuity (VA) category after a minimum of 1 year. Secondary outcomes were numbers and causes of complications and refractive corrections. RESULTS: Of the 110 participants recruited, 98 (89%) were assessed at least 1 year after the operation (median follow up 17.5 months). Nine eyes randomised to PC IOL were converted to AC IOL; one eye randomised to AC IOL inadvertently received PC IOL. There was no difference in VA between 95 pairs of eyes for which data for both eyes were available (uncorrected VA, p = 0.26; corrected VA, p = 0.59). 80 (82%, 95% CI 73 to 89) and 82 (84%, 95% CI 75 to 90) eyes randomised to AC IOL and PC IOL respectively had corrected VA of 6/18 or better. 16 (16%, 95% CI 10 to 25) and eight (8%, 95% CI 4 to 15) eyes respectively had secondary procedures or other complications. CONCLUSIONS: Where both strategies are available, ECCE with PC IOL should be first choice because of fewer complications. Where ECCE with PC IOL is not immediately feasible, ICCE with AC IOL is an acceptable interim technique

Developmental Changes in Infants' Categorization of Anger and Disgust Facial Expressions

For decades, scholars have examined how children first recognize emotional facial expressions. This research has found that infants younger than 10 months can discriminate negative, within-valence facial expressions in looking time tasks, and children older than 24 months struggle to categorize these expressions in labeling and free-sort tasks. Specifically, these older children, and even adults, consistently misidentify disgust expressions as anger. Although some scholars have hypothesized that young infants would also be unable to categorize anger and disgust expressions, this question has not been empirically tested. In addition, very little research has examined developmental changes in infants' perceptual categorization abilities with high arousal, within-valence emotions. For this reason, the current study tested 10- and 18-month-olds in a looking time task and found that both age groups could perceptually categorize anger and disgust facial expressions. Furthermore, 18-month-olds showed a heightened sensitivity to novel anger expressions, suggesting that, over the second year of life, infants' emotion categorization skills undergo developmental change. These findings are the first to demonstrate that young infants can categorize anger and disgust facial expressions and to document how this skill develops and changes over time

Transitions in coral reef accretion rates linked to intrinsic ecological shifts on turbid-zone nearshore reefs

This is the final version of the article. Available from the Geological Society of America via the DOI in this record.Nearshore coral communities within turbid settings are typically perceived to have limited reef-building capacity. However, several recent studies have reported reef growth over millennial time scales within such environments and have hypothesized that depth-variable community assemblages may act as equally important controls on reef growth as they do in clear-water settings. Here, we explicitly test this idea using a newly compiled chronostratigraphic record (31 cores, 142 radiometric dates) from seven proximal (but discrete) nearshore coral reefs located along the central Great Barrier Reef (Australia). Uniquely, these reefs span distinct stages of geomorphological maturity, as reflected in their elevations below sea level. Integrated age-depth and ecological data sets indicate that contemporary coral assemblage shifts, associated with changing light availability and wave exposure as reefs shallowed, coincided with transitions in accretion rates at equivalent core depths. Reef initiation followed a regional ∼1 m drop in sea level (1200–800 calibrated yr B.P.) which would have lowered the photic floor and exposed new substrate for coral recruitment by winnowing away fine seafloor sediments. We propose that a two-way feedback mechanism exists where past growth history influences current reef morphology and ecology, ultimately driving future reef accumulation and morphological change. These findings provide the first empirical evidence that nearshore reef growth trajectories are intrinsically driven by changes in coral community structure as reefs move toward sea level, a finding of direct significance for predicting the impacts of extrinsically driven ecological change (e.g., coral-algal phase shifts) on reef growth potential within the wider coastal zone on the Great Barrier Reef.This work was supported by Natural Environment Research Council (NERC) grant NE/J023329/1 to Perry and Smithers and NERC Radiocarbon Dating Allocations 1727.1013 and 1838.1014 to Morgan, Perry, and Gulliver

Improved timed-mating, non-invasive method using fewer unproven female rats with pregnancy validation via early body mass increases

For studies requiring accurate conception-timing, reliable, efficient methods of detecting oestrus reduce time and costs, whilst improving welfare. Standard methods use vaginal cytology to stage cycle, and breeders are paired–up using approximately five proven females with proven males to achieve at least one conception on a specific day. We describe an alternative, fast, consistent, non-invasive method of timed-mating using detection of lordosis behaviour in Wistar and Lister-Hooded rats that used unproven females with high success rates. Rats under reverse-lighting had body masses recorded pre-mating, day (d) 3-4, d8, d10 and d18 of pregnancy. Using only the presence of the oestrus dance to time-mate females for 24-hrs, 89% Wistar and 88% Lister-Hooded rats successfully conceived. We did not observe behavioural oestrus in Sprague-Dawleys without males present. Significant body mass increases following mating distinguished pregnant from non-pregnant rats, as early as d4 of pregnancy (10% ± 1.0 increase cf 3% ± 1.2). The pattern of increases throughout gestation was similar for all pregnant rats until late pregnancy, when there were smaller increases for primi- and multiparous rats (32% ± 2.5; 25% ± 2.4), whereas nulliparous rats had highest gains (38% ± 1.5). This method demonstrated a distinct refinement of the previous timed-mating common practice used, as disturbance of females was minimised. Only the number required of nulli-, primi- or multiparous rats were mated, and body mass increases validated pregnancy status. This new breeding-management method is now established practice for two strains of rat and resulted in a reduction in animal use

TOPOGRAPHIC ROSSBY WAVES ABOVE A RANDOM ARRAY OF SEA-MOUNTAINS

The barotropic potential vorticity equation or topographic wave equation is not linear in topography: the solution structure for topography formed from a sum of obstacles is not the sum of solutions for the obstacles in isolation, even when these individual solutions have identical frequencies. This paper considers the mechanism by which normal modes of oscillation above one mountain are modified by interactions with its neighbours. Exact explicit solutions for the normal modes above a pair of circular seamountains show that the interactions between the mountains rapidly approaches the large-separation approximation obtained by considering solely the first reflection of the disturbance of one mountain at the other. For mountains of one diameter separation at the closest point, the approximation is accurate to within 1%. Perhaps surprisingly, coupling between two identical mountains is weak and resonance occurs between mountains and dales of equal and opposite height. The accurate approximate solutions enable consideration of the effects on a mountain of an infinite set of randomly distributed neighbours. The ensembleaveraged frequency for a mountain of given height is determined in terms of the area fraction of the other mountains. The idea of an effective topography is introduced for the ensemble-averaged stream function: it is that (non-random) topography generating a stream function identical to the ensemble-averaged stream function. This differs markedly from the ensemble-averaged topography. The explicit form of the effective topography is derived for a set of right circular cylinders

SLOW ENERGY-TRANSFER BETWEEN REGIONS SUPPORTING TOPOGRAPHIC WAVES

In a recent paper (Jansons & Johnson 1988) the authors discuss topographic Rossby waves over a random array of seamounts. It is noted that resonance is possible between a hill and an equal and opposite dale but such resonances are mentioned only briefly due to the small likelihood of correctly matched topography in the ocean. The present paper considers the resonances in detail showing how the normal modes formed by frequency splitting at resonance can be combined to give modes that slowly transfer energy from one region supporting topographic waves, across a region where such weaves are evanescent, to another region supporting waves. In addition to the simplest case of a hill—dale pair for which an exact energy-transferring mode is obtained, transferring modes are given for a three-hill system, for two hills near a coastal boundary, and for two-basin lakes. The analysis is simplified and the results generalized by extensive use of the invariance of the governing equation under conformal mappings. A transferring mode is given for a dale in a random array of seamounts showing energy leaking slowly from the dale to large distances and returning, with the rate of leakage depending on the area fraction of seamounts. It is concluded that although resonances and transferring modes are not likely to be important in random arrays on infinite planes, they are relevant to numerical models, which are necessarily restricted to finite domains, to coastal seamount chains, and to multi-basin lakes