A Larger Meaning, a Larger Purpose

We must always be thinking about the next war, about the twenty-first cen- tury. The only thing that we can say with certainty is that things will change. They will change dramatically, and we will be surprised. Twenty-nine years ago, when I matriculated at the Naval War College in Au- gust 1974, the world was also undergoing a time of great change and surprise. President Richard Nixon resigned, and Gerald Ford became president. Con- gressman Carl Albert was the speaker of the House. Mike Mansfield was the majority leader. The year I graduated, 1975, was a very difficult one for me and for the nation

Equation-free implementation of statistical moment closures

We present a general numerical scheme for the practical implementation of statistical moment closures suitable for modeling complex, large-scale, nonlinear systems. Building on recently developed equation-free methods, this approach numerically integrates the closure dynamics, the equations of which may not even be available in closed form. Although closure dynamics introduce statistical assumptions of unknown validity, they can have significant computational advantages as they typically have fewer degrees of freedom and may be much less stiff than the original detailed model. The closure method can in principle be applied to a wide class of nonlinear problems, including strongly-coupled systems (either deterministic or stochastic) for which there may be no scale separation. We demonstrate the equation-free approach for implementing entropy-based Eyink-Levermore closures on a nonlinear stochastic partial differential equation.Comment: 7 pages, 2 figure

Sensor corrections for Sea-Bird SBE-41CP and SBE-41 CTDs

Author Posting. © American Meteorological Society, 2007. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Atmospheric and Oceanic Technology 24 (2007): 1117-1130, doi:10.1175/JTECH2016.1.Sensor response corrections for two models of Sea-Bird Electronics, Inc., conductivity–temperature–depth (CTD) instruments (the SBE-41CP and SBE-41) designed for low-energy profiling applications were estimated and applied to oceanographic data. Three SBE-41CP CTDs mounted on prototype ice-tethered profilers deployed in the Arctic Ocean sampled diffusive thermohaline staircases and telemetered data to shore at their full 1-Hz resolution. Estimations of and corrections for finite thermistor time response, time shifts between when a parcel of water was sampled by the thermistor and when it was sampled by the conductivity cell, and the errors in salinity induced by the thermal inertia of the conductivity cell are developed with these data. In addition, thousands of profiles from Argo profiling floats equipped with SBE-41 CTDs were screened to select examples where thermally well-mixed surface layers overlaid strong thermoclines for which standard processing often yields spuriously fresh salinity estimates. Hundreds of profiles so identified are used to estimate and correct for the conductivity cell thermal mass error in SBE-41 CTDs.The National Ocean Partnership Program and the National Oceanic and Atmospheric Administration (NOAA) Office of Oceanic and Atmospheric Research funded this analysis. The ITP data were acquired under National Science Foundation (NSF) Grant OCE0324233

Dynamics of Cortical Degeneration Over a Decade in Huntington's Disease

BACKGROUND: Characterizing changing brain structure in neurodegeneration is fundamental to understanding longterm effects of pathology and ultimately providing therapeutic targets. It is well established that Huntington’s disease (HD) gene carriers undergo progressive brain changes during the course of disease, yet the long-term trajectory of cortical atrophy is not well defined. Given that genetic therapies currently tested in HD are primarily expected to target the cortex, understanding atrophy across this region is essential. METHODS: Capitalizing on a unique longitudinal dataset with a minimum of 3 and maximum of 7 brain scans from 49 HD gene carriers and 49 age-matched control subjects, we implemented a novel dynamical systems approach to infer patterns of regional neurodegeneration over 10 years. We use Bayesian hierarchical modeling to map participant- and group-level trajectories of atrophy spatially and temporally, additionally relating atrophy to the genetic marker of HD (CAG-repeat length) and motor and cognitive symptoms. RESULTS: We show, for the first time, that neurodegenerative changes exhibit complex temporal dynamics with substantial regional variation around the point of clinical diagnosis. Although widespread group differences were seen across the cortex, the occipital and parietal regions undergo the greatest rate of cortical atrophy. We have established links between atrophy and genetic markers of HD while demonstrating that specific cortical changes predict decline in motor and cognitive performance. CONCLUSIONS: HD gene carriers display regional variability in the spatial pattern of cortical atrophy, which relates to genetic factors and motor and cognitive symptoms. Our findings indicate a complex pattern of neuronal loss, which enables greater characterization of HD progression

MaxEnt power spectrum estimation using the Fourier transform for irregularly sampled data applied to a record of stellar luminosity

The principle of maximum entropy is applied to the spectral analysis of a data signal with general variance matrix and containing gaps in the record. The role of the entropic regularizer is to prevent one from overestimating structure in the spectrum when faced with imperfect data. Several arguments are presented suggesting that the arbitrary prefactor should not be introduced to the entropy term. The introduction of that factor is not required when a continuous Poisson distribution is used for the amplitude coefficients. We compare the formalism for when the variance of the data is known explicitly to that for when the variance is known only to lie in some finite range. The result of including the entropic measure factor is to suggest a spectrum consistent with the variance of the data which has less structure than that given by the forward transform. An application of the methodology to example data is demonstrated.Comment: 15 pages, 13 figures, 1 table, major revision, final version, Accepted for publication in Astrophysics & Space Scienc

Naturally processed measles virus peptide eluted from class II HLA-DRB1*03 recognized by T lymphocytes from human blood

AbstractThis is the first report of the direct identification of a HLA-DRB1*03 measles-derived peptide from measles virus infected EBV-transformed B cells. We purified HLA-DR3-peptide complexes from EBV-B cells infected with measles virus (Edmonston strain) and sequenced the HLA-DR3-peptides by mass spectrometry. A class II peptide, derived from a measles phosphoprotein, ASDVETAEGGEIHELLRLQ (P1, residues 179–197), exhibited the capacity to stimulate peripheral blood mononuclear cells to proliferate. Our data provides direct evidence that the antigenic peptide of measles virus was processed by antigen-presenting cells, presented in the context of HLA class II molecules, and was recognized by peripheral blood T cells from healthy individuals previously immunized with measles vaccine. The approach described herein provides a useful methodology for the future identification of HLA-presented pathogen-derived epitopes using mass spectrometry. The study of cell-mediated immune responses to the measles-derived peptide in immune persons should provide significant insight into the design and development of new vaccines

An Eccentric Hot Jupiter Orbiting the Subgiant HD 185269

We report the detection of a Jupiter-mass planet in a 6.838 day orbit around the 1.28 solar mass subgiant HD 185269. The eccentricity of HD 185269b (e = 0.30) is unusually large compared to other planets within 0.1 AU of their stars. Photometric observations demonstrate that the star is constant to +/-0.0001 mag on the radial velocity period, strengthening our interpretation of a planetary companion. This planet was detected as part of our radial velocity survey of evolved stars located on the subgiant branch of the H-R diagram--also known as the Hertzsprung Gap. These stars, which have masses between 1.2 and 2.5 solar masses, play an important role in the investigation of the frequency of extrasolar planets as a function of stellar mass.Comment: 18 pages, 4 figures, 3 tables, ApJ in press (scheduled for Dec 2006, v652n2

Surprising Connections Between General Relativity and Condensed Matter

This brief review is intended to introduce gravitational physicists to recent developments in which general relativity is being used to describe certain aspects of condensed matter systems, e.g., superconductivity.Comment: 14 pages; based on talk given at GR1

Five Planets Orbiting 55 Cancri

We report 18 years of Doppler shift measurements of a nearby star, 55 Cancri, that exhibit strong evidence for five orbiting planets. The four previously reported planets are strongly confirmed here. A fifth planet is presented, with an apparent orbital period of 260 days, placing it 0.78 AU from the star in the large empty zone between two other planets. The velocity wobble amplitude of 4.9 \ms implies a minimum planet mass \msini = 45.7 \mearthe. The orbital eccentricity is consistent with a circular orbit, but modest eccentricity solutions give similar \chisq fits. All five planets reside in low eccentricity orbits, four having eccentricities under 0.1. The outermost planet orbits 5.8 AU from the star and has a minimum mass, \msini = 3.8 \mjupe, making it more massive than the inner four planets combined. Its orbital distance is the largest for an exoplanet with a well defined orbit. The innermost planet has a semi-major axis of only 0.038 AU and has a minimum mass, \msinie, of only 10.8 \mearthe, one of the lowest mass exoplanets known. The five known planets within 6 AU define a {\em minimum mass protoplanetary nebula} to compare with the classical minimum mass solar nebula. Numerical N-body simulations show this system of five planets to be dynamically stable and show that the planets with periods of 14.65 and 44.3 d are not in a mean-motion resonance. Millimagnitude photometry during 11 years reveals no brightness variations at any of the radial velocity periods, providing support for their interpretation as planetary.Comment: accepted to Ap

Deep and abyssal ocean warming from 35 years of repeat hydrography

Global and regional ocean warming deeper than 2000 m is investigated using 35 years of sustained repeat hydrographic survey data starting in 1981. The global long-term temperature trend below 2000 m, representing the time period 1991–2010, is equivalent to a mean heat flux of 0.065 ± 0.040 W m?2 applied over the Earth's surface area. The strongest warming rates are found in the abyssal layer (4000–6000 m), which contributes to one third of the total heat uptake with the largest contribution from the Southern and Pacific Oceans. A similar regional pattern is found in the deep layer (2000–4000 m), which explains the remaining two thirds of the total heat uptake yet with larger uncertainties. The global average warming rate did not change within uncertainties pre-2000 versus post-2000, whereas ocean average warming rates decreased in the Pacific and Indian Oceans and increased in the Atlantic and Southern Oceans