Prednisolone versus placebo addition in the treatment of patients with recent-onset psychotic disorder: a trial design

BACKGROUND: The symptom severity of a substantial group of schizophrenia patients (30-40%) does not improve through pharmacotherapy with antipsychotic medication, indicating a clear need for new treatment options to improve schizophrenia outcome. Meta-analyses, genetic studies, randomized controlled trials, and post-mortem studies suggest that immune dysregulation plays a role in the pathophysiology of schizophrenia. Some anti-inflammatory drugs have shown beneficial effects on the symptom severity of schizophrenia patients. Corticosteroids are effective in various chronic inflammatory and autoimmune disorders. Prednisolone, a potent glucocorticosteroid, has minor mineral-corticosteroid potencies and can adequately pass the blood-brain barrier

Deadlock detection in linear recursive programs

Abstract. Deadlock detection in recursive programs that admit dynamic resource creation is extremely complex and solutions either give imprecise answers or do not scale. We define an algorithm for detecting deadlocks of linear recursive programs of a basic model. The theory that underpins the algorithm is a generalization of the theory of permutations of names to so-called mutations, which transform tuples by introducing duplicates and fresh names. Our algorithm realizes the back-end of deadlock analyzers for objectoriented programming languages, once the association programs/basicmodel-programs has been defined as front-end.