Core Support

Philanthropy's primary funding strategy -- restricted grants -- too often hamstrings grantees' ability to plan, invest, and respond to changes with vision, flexibility, and innovation. Since its inception, the F.B. Heron Foundation has primarily made core support grants. We believe that core support promotes effectiveness, innovation, leverage, and transparency among our grantees, as well as more candor between grantee and grantor. In this essay, we add our voice to the ongoing dialogue about a better balance between core support and restricted grants

Are High Wage Jobs Hazardous to Your Health? The Myth That Attracting Higher Paying Extractive Industry Jobs Is a Desirable Community Economic Development Strategy

Community/Rural/Urban Development,

Activation of Protein Kinase C Modulates Light Responses in Horizontal Cells of the Turtle Retina

The effect of phorbol esters on the light-evoked responses of horizontal cells were studied in the turtle eyecup preparation. Phorbol esters caused a reduction in receptive field size and a significant decrease in the amplitude of responses to annular and full-field illumination; however, they caused only minor changes in responses to small spots in the receptive field centre. The dark membrane potential was not affected. The results suggest that phorbol esters may affect both coupling resistance and membrane resistance in horizontal cells. The effects of phorbol esters were blocked by the protein kinase C inhibitor staurosporine, and inactive phorbol ester had no effect, making it very likely that the phorbol ester effects were mediated through activation of protein kinase C. The above effects of the phorbol esters were considerably reduced by the dopamine antagonists haloperidol and fluphenazine, suggesting that they were in part mediated by release of dopamine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73620/1/j.1460-9568.1992.tb00183.x.pd

TeV gamma-rays from photo-disintegration/de-excitation of cosmic-ray nuclei

It is commonly assumed that high-energy gamma-rays are made via either purely electromagnetic processes or the hadronic process of pion production, followed by decay. We investigate astrophysical contexts where a third process (A*) may dominate, namely the photo-disintegration of highly boosted nuclei followed by daughter de-excitation. Starbust regions such as Cygnus OB2 appear to be promising sites for TeV gamma-ray emission via this mechanism. A unique feature of the A* process is a sharp energy minimum ~ 10 TeV/(T/eV) for gamma-ray emission from a thermal region of temperature T. We also check that a diffuse gamma-ray component resulting from the interaction of a possible extreme-energy cosmic-ray nuclei with background radiation is well below the observed EGRET data. The A* mechanism described herein offers an important contribution to gamma-ray astronomy in the era of intense observational activity.Comment: To be published in Phys. Rev. Let

Army architects : The Royal Engineers and the development of building technology in the nineteenth century.

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