Overlapped plots of matching APs for two APs belonging to different classes.

<p>It can be observed that the variations in the matching APs given in the left panel is higher as compared to those in right. This difference is expressed in the root mean square error (RMSE) values given in the legend.</p

Overlaid plots of a typical Type B sAP (solid line) and the native AP template obtained from the Type A sAP decomposition (dashed line).

<p>The amplitudes are normalized and the peaks aligned at time = 0 ms. Note the slow ramp component which is a signature component of Type B sAP.</p

Schematic figure depicting the hypothesis that the variations in AP shape is caused by an underlying sEJP [16].

<p>Note that when the amplitude of the underlying sEJP is larger (left) the resultant AP has a taller foot, larger afterdepolarization and no afterhyperpolarization.</p

The replication efficiencies obtained for different data sets used in the study.

<p>The replication efficiencies obtained for different data sets used in the study.</p

The pooled summary of different types of signals available in the cell recordings used in the study.

<p>The pooled summary of different types of signals available in the cell recordings used in the study.</p

Features and terminology used in the work indicated on a sample AP.

<p>Features and terminology used in the work indicated on a sample AP.</p

The extraction of slow AHP signal from a typical G1 AP.

<p>(a) The G1 AP from which the sAHP is to be extracted. The onset and end of first repolarization (EoFR) of the AP are marked. (b) The set of G0 APs which are peak aligned with G1 AP in (a) and matched against the Onset-EoFR window of G1 AP. The best matching AP is shown in a thicker trace. (c) The estimate of the sAHP component contained in the G1 AP obtained by subtracting the best matching G0 AP from the G1 AP.</p

The examples of good replications of the experimentally obtained intracellular sAPs obtained using the proposed 4-component model.

<p>The traces in blue are the recorded signals, and the green traces are the synthesized signals. Only the sAPS belonging to the Test set are shown.</p

One example each for AP signals displaying (left) slow afterhyperpolarization (sAHP) and (right) very slow afterhyperpolarization (vsAHP).

<p>Note the difference in amplitudes and time spans of the hyperpolarization. The presence of slow AHP in an AP cannot be explained by the underlying-sEJP hypothesis, indicating the presence of more components.</p

A schematic diagram showing the attenuation of the AP foot convexity and after depolarization amplitude based on distance from the varicosity.

<p>The smooth muscle cells, connected via the gap junctions allow the unattenuated active transmission of APs (shown in black trace). The underlying sEJP (shown in blue trace) is passive signal and is attenuated with distance. The reduced amplitude of the underlying sEJP over distance is visible in the foot and the ADP amplitude (indicated by the arrows) of the observed sAP. At a sufficiently large distance, the underlying sEJP disappears and the observed AP attains the shape of the native AP.</p