Prospects for India's cereal supply and demand to 2020:

The possibility of an emerging cereal gap of serious proportions by the year 2020, is a useful illustration of the kind of constructive dialogue IFPRI hopes to encourage. It responds to several quite recent developments, notably the rapid expansion of India's industrial and service sectors since the 1991 structural reforms, the improved prospects for continued growth over the next few decades, and the likelihood of rising per capita incomes that could generate substantially increased demand for livestock products. As demand for livestock products grows, livestock production could increasingly depend on cereals for feed — perhaps as much as 50 million tons by 2020, according to G.S. Bhalla, Peter Hazell, and John Kerr, authors of this 2020 discussion paper on Prospects for Balancing Cereal Needs in India to 2020. These conclusions differ somewhat from other IFPRI studies, which have generally found that growth in demand for livestock products will be lower than the current study. This divergence of views is a useful signal to policymakers to pay careful attention to trends in demand for livestock products in India in the coming years. This study and the rest of IFPRI's 2020 research have consistently pointed to the vital link between agricultural policies and prospects for production growth in the next two decades. (from Forward by Per Pinstrup-Andersen)South Asia, South Asia and Central Asia, Grain Yields India., Food supply India Forecasting., Grain as feed India Forecasting., Consumption (Economics) India., Livestock India.,

Prospects for India's cereal supply and demand to 2020:

The possibility of an emerging cereal gap of serious proportions by the year 2020, is a useful illustration of the kind of constructive dialogue IFPRI hopes to encourage. It responds to several quite recent developments, notably the rapid expansion of India's industrial and service sectors since the 1991 structural reforms, the improved prospects for continued growth over the next few decades, and the likelihood of rising per capita incomes that could generate substantially increased demand for livestock products. As demand for livestock products grows, livestock production could increasingly depend on cereals for feed — perhaps as much as 50 million tons by 2020, according to G.S. Bhalla, Peter Hazell, and John Kerr, authors of this 2020 discussion paper on Prospects for Balancing Cereal Needs in India to 2020. These conclusions differ somewhat from other IFPRI studies, which have generally found that growth in demand for livestock products will be lower than the current study. This divergence of views is a useful signal to policymakers to pay careful attention to trends in demand for livestock products in India in the coming years. This study and the rest of IFPRI's 2020 research have consistently pointed to the vital link between agricultural policies and prospects for production growth in the next two decades. (from Forward by Per Pinstrup-Andersen)Grain Yields India., Food supply India Forecasting., Grain as feed India Forecasting., Consumption (Economics) India., Livestock India.,

Pion-Nucleus Scattering at Medium Energies with Densities from Chiral Effective Field Theories

Recently developed chiral effective field theory models provide excellent descriptions of the bulk characteristics of finite nuclei, but have not been tested with other observables. In this work, densities from both relativistic point-coupling models and mean-field meson models are used in the analysis of meson-nucleus scattering at medium energies. Elastic scattering observables for 790 MeV/$c$ $\pi^{\pm}$ on $^{208}$Pb are calculated in a relativistic impulse approximation, using the Kemmer-Duffin-Petiau formalism to calculate the $\pi^{\pm}$ nucleus optical potential.Comment: 9 page

Pharmacological Preconditioning with GYKI 52466: A Prophylactic Approach to Neuroprotection.

Some toxins and drugs can trigger lasting neuroprotective mechanisms that enable neurons to resist a subsequent severe insult. This "pharmacological preconditioning" has far-reaching implications for conditions in which blood flow to the brain is interrupted. We have previously shown that in vitro preconditioning with the AMPA receptor antagonist GYKI 52466 induces tolerance to kainic acid (KA) toxicity in hippocampus. This effect persists well after washout of the drug and may be mediated via inverse agonism of G-protein coupled receptors (GPCRs). Given the amplifying nature of metabotropic modulation, we hypothesized that GYKI 52466 may be effective in reducing seizure severity at doses well below those normally associated with adverse side effects. Here we report that pharmacological preconditioning with low-dose GYKI imparts a significant protection against KA-induced seizures in vivo. GYKI (3 mg/kg, s.c.), 90-180 min prior to high-dose KA, markedly reduced seizure scores, virtually abolished all level 3 and level 4 seizures, and completely suppressed KA-induced hippocampal c-FOS expression. In addition, preconditioned animals exhibited significant reductions in high frequency/high amplitude spiking and ECoG power in the delta, theta, alpha, and beta bands during KA. Adverse behaviors often associated with higher doses of GYKI were not evident during preconditioning. The fact that GYKI is effective at doses well-below, and at pre-administration intervals well-beyond previous studies, suggests that a classical blockade of ionotropic AMPA receptors does not underlie anticonvulsant effects. Low-dose GYKI preconditioning may represent a novel, prophylactic strategy for neuroprotection in a field almost completely devoid of effective pharmaceuticals

Changes in perceived scientific consensus shift beliefs about climate change and GM food safety.

Despite an overwhelming scientific consensus, a sizable minority of people doubt that human activity is causing climate change. Communicating the existence of a scientific consensus has been suggested as a way to correct individuals' misperceptions about human-caused climate change and other scientific issues, though empirical support is mixed. We report an experiment in which psychology students were presented with consensus information about two issues, and subsequently reported their perception of the level of consensus and extent of their endorsement of those issues. We find that messages about scientific consensus on the reality of anthropogenic climate change and the safety of genetically modified food shift perceptions of scientific consensus. Using mediation models we also show that, for both these issues, high consensus messages also increase reported personal agreement with the scientific consensus, mediated by changes in perceptions of a scientific consensus. This confirms the role of perceived consensus in informing personal beliefs about climate change, though results indicate the impact of single, one-off messages may be limited

Crystal structures of four indole derivatives as possible cannabinoid allosteric antagonists

Acknowledgements We thank the EPSRC National Crystallography Service (University of Southampton) for the data collections and the EPSRC National Mass Spectrometry Service (University of Swansea) for the HRMS data. We thank John Low for carrying out the Cambridge Database survey.Peer reviewedPublisher PD

Communicating expert consensus increases personal support for COVID-19 mitigation policies.

Funder: Science Foundation IrelandThe Gateway Belief Model (GBM) places perception of a scientific consensus as a key "gateway cognition" with cascading effects on personal beliefs, concern, and ultimately support for public policies. However, few studies seeking to evaluate and extend the model have followed the specification and design of the GBM as originally outlined. We present a more complete test of the theoretical model in a novel domain: the COVID-19 pandemic. In a large multi-country correlational study (N = 7,206) we report that, as hypothesized by the model, perceptions of scientific consensus regarding the threat of COVID-19 predict personal attitudes toward threat and worry over the virus, which are in turn positively associated with support for mitigation policies. We also find causal support for the model in a large pre-registered survey experiment (N = 1,856): experimentally induced increases in perceived consensus have an indirect effect on changes in policy support mediated via changes in personal agreement with the consensus. Implications for the role of expert consensus in science communication are discussed

Change over a 16-month period in the psychological well-being of mothers of girls and women with Rett syndrome

PURPOSE: There is an emerging research literature on the experiences of family members of girls and women with Rett syndrome (RTT), but a lack of longitudinal data. METHODS: Fifty mothers whose daughters had RTT were surveyed 16-17 months after an earlier cross-sectional study. Measures completed at both time points focused on maternal positive and negative psychological well-being and their daughters' behavioral and emotional problems and RTT behavioral phenotype severity. RESULTS: Maternal stress, anxiety, and depression demonstrated at least moderate levels of stability. Maternal positive perceptions were also moderately stable over 16-17 months. Longitudinal analyses suggested that their daughters' behavioral and emotional problems rather than RTT behavioral phenotype severity predicted later maternal well-being. CONCLUSION: Mothers with RTT daughters experience chronic stress (persisting over time) but also ongoing positive perceptions. Practitioners should recognize positive perceptions and also consider targeted behavioral parent training to reduce behavior problems in individuals with RTT

Cytology for PD-L1 testing : A systematic review

Medical writing support, which was in accordance with Good Publication Practice (GPP3) guidelines, was provided by Craig Turner, MSc, of Cirrus Communications (Macclesfield, UK), an Ashfield company, and was funded by AstraZenecaPeer reviewedPublisher PD

System of accounts for live-stock shipping associations

The system of accounts devised by the Office of Markets and Rural Organization and described in this bulletin has been so constructed as to meet the requirements of shipping associations under varying conditions at a minimum expenditure of time and bookkeeping effort,1 and is the result of investigations made by the office in cooperation with several live-stock shipping associations in various States where the system is now in successful operation. Special care has been taken to make the method of application as direct as possible and to cut to a minimum the number of forms necessary to do the work properly. It is well understood that not all the forms included in the system will be needed under every condition of operation, but such forms as are suggested will be found practicable for use in every association attempting to keep an accurate account of the transaction of its business