Flowchart outlining the steps in the gain-of-function and loss-of-function genomic screens

The gain-of-function screen was used to identify positive modifiers of the NFκB signaling pathway and the loss-of-function screen was used to identify negative modifiers. Approximately 14,500 full-length human and mouse genes were screened for activity.<p><b>Copyright information:</b></p><p>Taken from "A functional map of NFκB signaling identifies novel modulators and multiple system controls"</p><p>http://genomebiology.com/2007/8/6/R104</p><p>Genome Biology 2007;8(6):R104-R104.</p><p>Published online 6 Jun 2007</p><p>PMCID:PMC2394752.</p><p></p

Functional classification of the NFκB modulators identified in the functional genomic screens

Functional classification was performed using NIH David 2.1. Classification of the positive modulators. Classification of the negative modulators.<p><b>Copyright information:</b></p><p>Taken from "A functional map of NFκB signaling identifies novel modulators and multiple system controls"</p><p>http://genomebiology.com/2007/8/6/R104</p><p>Genome Biology 2007;8(6):R104-R104.</p><p>Published online 6 Jun 2007</p><p>PMCID:PMC2394752.</p><p></p

Spatial gene expression of the gene variants suggests only the isoform represented by RefSeq NM 028755 may be involved in the striatal cAMP signaling pathway

<p><b>Copyright information:</b></p><p>Taken from "Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas"</p><p>http://www.biomedcentral.com/1752-0509/1/19</p><p>BMC Systems Biology 2007;1():19-19.</p><p>Published online 16 Apr 2007</p><p>PMCID:PMC1863433.</p><p></p> The striatum region is outlined by a red box. Brain images were obtained from the ABA database and the tissue gene expression data were obtained from GNF SymAtlas

Genes involved in the neuronal cAMP signaling pathway share a similar striatum-enriched hybridization profile to

<p><b>Copyright information:</b></p><p>Taken from "Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas"</p><p>http://www.biomedcentral.com/1752-0509/1/19</p><p>BMC Systems Biology 2007;1():19-19.</p><p>Published online 16 Apr 2007</p><p>PMCID:PMC1863433.</p><p></p> Brain images were obtained from the ABA, GenePaint.org, and GENSAT databases. The striatum region is outlined in ABA-2175

Expression analysis of G Protein-Coupled Receptors in mouse macrophages-1

Of 91 murine cell types and tissues. Data points show normalised values and similar cell types are grouped according to bar colour; blue indicates primary macrophage cell types, purple indicates bone-related cell types, red indicates other immune cell types, green indicates stem cell populations, orange indicates whole tissue samples, yellow indicates neuronal and retinal cell types and pink indicates cell lines. Additional file gives details of the 91 cell types and tissues profiled.<p><b>Copyright information:</b></p><p>Taken from "Expression analysis of G Protein-Coupled Receptors in mouse macrophages"</p><p>http://www.immunome-research.com/content/4/1/5</p><p>Immunome Research 2008;4():5-5.</p><p>Published online 29 Apr 2008</p><p>PMCID:PMC2394514.</p><p></p

Expression analysis of G Protein-Coupled Receptors in mouse macrophages-2

over a timecourse of 0, 2, 6, and 24 h, and 0, 1 and 7 h, respectively. Data points show gene expression relative to untreated control for each cell population (0 h).<p><b>Copyright information:</b></p><p>Taken from "Expression analysis of G Protein-Coupled Receptors in mouse macrophages"</p><p>http://www.immunome-research.com/content/4/1/5</p><p>Immunome Research 2008;4():5-5.</p><p>Published online 29 Apr 2008</p><p>PMCID:PMC2394514.</p><p></p

Expression analysis of G Protein-Coupled Receptors in mouse macrophages-0

Of 91 murine cell types and tissues. Data points show normalised values and similar cell types are grouped according to bar colour; blue indicates primary macrophage cell types, purple indicates bone-related cell types, red indicates other immune cell types, green indicates stem cell populations, orange indicates whole tissue samples, yellow indicates neuronal and retinal cell types and pink indicates cell lines. Additional file gives details of the 91 cell types and tissues profiled.<p><b>Copyright information:</b></p><p>Taken from "Expression analysis of G Protein-Coupled Receptors in mouse macrophages"</p><p>http://www.immunome-research.com/content/4/1/5</p><p>Immunome Research 2008;4():5-5.</p><p>Published online 29 Apr 2008</p><p>PMCID:PMC2394514.</p><p></p