2-Diazo-1-(4-hydroxyphenyl)ethanone: A Versatile Photochemical and Synthetic Reagent

α-Diazo arylketones are well-known substrates for Wolff rearrangement to phenylacetic acids through a ketene intermediate by either thermal or photochemical activation. Likewise, α-substituted p-hydroxyphenacyl (pHP) esters are substrates for photo-Favorskii rerrangements to phenylacetic acids by a different pathway that purportedly involves a cyclopropanone intermediate. In this paper, we show that the photolysis of a series of α-diazo-p-hydroxyacetophenones and p-hydroxyphenacyl (pHP) α-esters both generate the identical rearranged phenylacetates as major products. Since α-diazo-p-hydroxyacetophenone (1a, pHP N2) contains all the necessary functionalities for either Wolff or Favorskii rearrangement, we were prompted to probe this intriguing mechanistic dichotomy under conditions favorable to the photo-Favorskii reangement, i.e., photolysis in hydroxylic media. An investigation of the mechanism for conversion of 1a to p-hydroxyphenyl acetic acid (4a) using time-resolved infrared (TRIR) spectroscopy clearly demonstrates the formation of a ketene intermediate that is subsequently trapped by solvent or nucleophiles. The photoreaction of 1a is quenched by oxygen and sensitized by triplet sensitizers and the quantum yields for 1a–c range from 0.19 to a robust 0.25. The lifetime of the triplet, determined by Stern-Volmer quenching, is 15 ns with a rate for appearance of 4a of k = 7,1 × 106 s−1 in aq. acetonitrile (1:1 v:v). These studies establish that the primary rearrangement pathway for 1a involves ketene formation in accordance with the photo-Wolff rearrangement. Furthermore we have also demonstrated the synthetic utility of 1a as an esterification and etherification reagent with a variety of substituted α-diazo-p-hydroxyacetophenones, using them as synthons for efficiently coupling it to acids and phenols to produce pHP protect substrates

Ex-nihilo II: Examination Syllabi and the Sequencing of Cosmology Education

Cosmology education has become an integral part of modern physics courses. Directed by National Curricula, major UK examination boards have developed syllabi that contain explicit statements about the model of the Big Bang and the strong observational evidence that supports it. This work examines the similarities and differences in these specifications, addresses when cosmology could be taught within a physics course, what should be included in this teaching and in what sequence it should be taught at different levels.Comment: 9 pages. Accepted for publication in a special issue of Physics Educatio

Coherent radar reflections from an electron-beam induced particle cascade

Experiment T-576 ran at SLAC in 2018, in development of a new radar-based detection scheme for ultra-high energy neutrinos. In this experiment, the electron beam (N∼109e− at ∼10 GeV) was directed into a plastic target to simulate a 1019 eV neutrino-induced shower in ice. This shower was interrogated with radio frequency (RF) radiation, in an attempt to measure a radar-like reflection from the ionization produced in the target during the particle shower. This technique could be employed to detect the rare interactions of ultra-high-energy neutrinos in dense material, such as polar ice sheets, extending the extant energy range of detected neutrinos up to EeV and beyond. In this proceeding, we detail the experiment and present results from the analysis and the observation of a signal consistent with a radar signal

Toward High Energy Neutrino Detection with the Radar Echo Telescope for Cosmic Rays (RET-CR)

The Radar Echo Telescope for Cosmic Rays (RET-CR) is a pathfinder experiment for the Radar Echo Telescope for Neutrinos (RET-N), a next-generation in-ice detection experiment for ultra high energy neutrinos. RET-CR will serve as the testbed for the radar echo method to probe high-energy particle cascades in nature, whereby a transmitted radio signal is reflected from the ionization left in its wake. This method, recently validated at SLAC experiment T576, shows promising preliminary sensitivity to neutrino-induced cascades above the energy range of optical detectors like IceCube. RET-CR intends to use an in-nature test beam: the dense, in-ice cascade produced when the air shower of an ultra high energy cosmic ray impacts a high-elevation ice sheet. This in-ice cascade, orders of magnitude more dense than the in-air shower that preceded it, is similar in profile and density to the expected cascade from a neutrino-induced cascade deep in the ice. RET-CR will be triggered using surface scintillator technology and will be used to develop, test, and deploy the hardware, firmware, and software needed for the eventual RET-N. We present the strategy, status, and design sensitivity of RET-CR, and discuss its application to eventual neutrino detection

Simulation and Optimisation for the Radar Echo Telescope for Cosmic Rays

The SLAC T-576 beam test experiment showed the feasibility of the radar detection technique to probe high-energy particle cascades in dense media. Corresponding particle-level simulations indicate that the radar method has very promising sensitivity to probe the > PeV cosmic neutrino flux. As such, it is crucial to demonstrate the in-situ feasibility of the radar echo method, which is the main goal of the current RET-CR experiment. Although the final goal of the Radar Echo Telescope is to detect cosmic neutrinos, we seek a proof of principle using cosmic-ray air showers penetrating the (high-altitude) Antarctic ice sheet. When an UHECR particle cascade propagates into a high-elevation ice sheet, it produces a dense in-ice cascade of charged particles which can reflect incoming radio waves. Using a surface cosmic-ray detector, the energy and direction of the UHECR can be reconstructed, and as such this constitutes a nearly ideal in-situ test beam to provide the proof of principle for the radar echo technique. RET-CR will consist of a transmitter array, receiver antennas and a surface scintillator plate array. Here we present the simulation efforts for RET-CR performed to optimise the surface array layout and triggering system, which affords an estimate of the expected event rate

Investigating signal properties of UHE particles using in-ice radar for the RET experiment

The Radar Echo Telescope (RET) experiment plans to use the radar technique to detect Ultra-High Energy (UHE) cosmic rays and neutrinos in the polar ice sheets. Whenever an UHE particle collides with an ice molecule, it produces a shower of relativistic particles, which leaves behind an ionization trail. Radio waves can be reflected off this trail and be detected in antennas. It is critical to understand such a radar signal's key properties as that will allow us to do vertex, angular and energy reconstruction of the primary UHE particle. We will discuss various simulation methods, which will fundamentally rely on ray tracing, to recreate the radar signal and test our reconstruction methods

The Radar Echo Telescope for Neutrinos (RET-N)

We present the Radar Echo Telescope for Neutrinos (RET-N). RET-N focuses on the detection of the cosmic neutrino flux above PeV energies by means of the radar detection technique. This method aims to bridge the energy gap between the diffuse neutrino flux detected by IceCube up to a few PeV and the sought for cosmogenic neutrinos at EeV energies by the in-ice Askaryan detectors, as well as the air-shower radio detectors. The radar echo method is based on the detection the ionization trail in the wake of a high-energy neutrino-induced particle cascade in ice. This technique, recently validated in a beam test (T576 at SLAC) is also the basis for the RET-N pathfinder experiment, RET-CR, which is currently under development. Based on the T-576 results, we show that the radar echo method leads to very promising sensitivities to detect cosmic neutrinos in the PeV-EeV region and above. We present the RET-N project and the results of our sensitivity studies

Application of parabolic equation methods to in-ice radiowave propagation for ultra high energy neutrino detection experiments

Many ultra-high-energy neutrino-detection experiments seek radio wave signals from neutrino interactions deep within the polar ice, and an understanding of in-ice radio wave propagation is therefore of critical importance. The parabolic equation (PE) method for modeling the propagation of radio waves is a suitable intermediate between ray tracing and finite-difference time domain (FDTD) methods in terms of accuracy and computation time. The RET collaboration has developed the first modification of the PE method for use in modeling in-ice radio wave propagation for ultra high energy cosmic ray and neutrino detection experiments. In this proceeding we will detail the motivation for the development of this technique, the process by which it was modified for in-ice use, and showcase the accuracy of its results by comparing to FDTD and ray tracing

The Radar Echo Telescope for Cosmic Rays

The Radar Echo Telescope for Cosmic Rays (RET-CR) was deployed in May 2023. RET-CR aims to show the in-nature viability of the radar echo method to probe in-ice particle cascades induced by ultra high energy cosmic rays and neutrinos. The RET-CR surface system detects ultra-high-energy cosmic ray air showers impinging on the ice using conventional methods. The surface detector then triggers the in-ice component of RET-CR, that is subsequently used to search for a radar echo off of the in-ice continuation of an ultra high energy cosmic ray air shower. The two systems independently reconstruct the energy, arrival direction, and impact point of the particle cascade. Here we present RET-CR, its installation in Greenland, and the first operations and results of RET-CR

Decreased Brain Volume in Adults with Childhood Lead Exposure

Using magnetic resonance imaging to assess brain volumes, Kim Cecil and colleagues find that inner-city children with higher blood lead levels showed regions of decreased gray matter as adults