Attenuation of Persistent L∞-Bounded Disturbances for Nonlinear Systems

A version of nonlinear generalization of the L1-control problem, which deals with the attenuation of persistent bounded disturbances in L∞-sense, is investigated in this paper. The methods used in this paper are motivated by [23]. The main idea in the L1-performance analysis and synthesis is to construct a certain invariant subset of the state-space such that achieving disturbance rejection is equivalent to restricting the state-dynamics to this set. The concepts from viability theory, nonsmooth analysis, and set-valued analysis play important roles. In addition, the relation between the L1-control of a continuous-time system and the l1-control of its Euler approximated discrete-time systems is established

Saturated locally optimal designs under differentiable optimality criteria

We develop general theory for finding locally optimal designs in a class of single-covariate models under any differentiable optimality criterion. Yang and Stufken [Ann. Statist. 40 (2012) 1665-1681] and Dette and Schorning [Ann. Statist. 41 (2013) 1260-1267] gave complete class results for optimal designs under such models. Based on their results, saturated optimal designs exist; however, how to find such designs has not been addressed. We develop tools to find saturated optimal designs, and also prove their uniqueness under mild conditions.Comment: Published in at http://dx.doi.org/10.1214/14-AOS1263 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

H∞ Control of Nonlinear Systems: A Class of Controllers

The standard state space solutions to the H∞ control problem for linear time invariant systems are generalized to nonlinear time-invariant systems. A class of nonlinear H∞-controllers are parameterized as nonlinear fractional transformations on contractive, stable free nonlinear parameters. As in the linear case, the H∞ control problem is solved by its reduction to four simpler special state space problems, together with a separation argument. Another byproduct of this approach is that the sufficient conditions for H∞ control problem to be solved are also derived with this machinery. The solvability for nonlinear H∞-control problem requires positive definite solutions to two parallel decoupled Hamilton-Jacobi inequalities and these two solutions satisfy an additional coupling condition. An illustrative example, which deals with a passive plant, is given at the end

ℋ∞ control of nonlinear systems via output feedback: controller parameterization

The standard state space solutions to the ℋ∞ control problem for linear time invariant systems are generalized to nonlinear time-invariant systems. A class of local nonlinear (output feedback) ℋ∞ controllers are parameterized as nonlinear fractional transformations on contractive, stable nonlinear parameters. As in the linear case, the ℋ∞ control problem is solved by its reduction to state feedback and output estimation problems, together with a separation argument. Sufficient conditions for ℋ∞-control problem to be locally solved are also derived with this machinery

H∞ control of nonlinear systems: a convex characterization

The nonlinear H∞-control problem is considered with an emphasis on developing machinery with promising computational properties. The solutions to H∞-control problems for a class of nonlinear systems are characterized in terms of nonlinear matrix inequalities which result in convex problems. The computational implications for the characterization are discussed

Statistical Mechanical Treatments of Protein Amyloid Formation

Protein aggregation is an important field of investigation because it is closely related to the problem of neurodegenerative diseases, to the development of biomaterials, and to the growth of cellular structures such as cyto-skeleton. Self-aggregation of protein amyloids, for example, is a complicated process involving many species and levels of structures. This complexity, however, can be dealt with using statistical mechanical tools, such as free energies, partition functions, and transfer matrices. In this article, we review general strategies for studying protein aggregation using statistical mechanical approaches and show that canonical and grand canonical ensembles can be used in such approaches. The grand canonical approach is particularly convenient since competing pathways of assembly and dis-assembly can be considered simultaneously. Another advantage of using statistical mechanics is that numerically exact solutions can be obtained for all of the thermodynamic properties of fibrils, such as the amount of fibrils formed, as a function of initial protein concentration. Furthermore, statistical mechanics models can be used to fit experimental data when they are available for comparison.Comment: Accepted to IJM

A Statistical Mechanical Approach to Protein Aggregation

We develop a theory of aggregation using statistical mechanical methods. An example of a complicated aggregation system with several levels of structures is peptide/protein self-assembly. The problem of protein aggregation is important for the understanding and treatment of neurodegenerative diseases and also for the development of bio-macromolecules as new materials. We write the effective Hamiltonian in terms of interaction energies between protein monomers, protein and solvent, as well as between protein filaments. The grand partition function can be expressed in terms of a Zimm-Bragg-like transfer matrix, which is calculated exactly and all thermodynamic properties can be obtained. We start with two-state and three-state descriptions of protein monomers using Potts models that can be generalized to include q-states, for which the exactly solvable feature of the model remains. We focus on n X N lattice systems, corresponding to the ordered structures observed in some real fibrils. We have obtained results on nucleation processes and phase diagrams, in which a protein property such as the sheet content of aggregates is expressed as a function of the number of proteins on the lattice and inter-protein or interfacial interaction energies. We have applied our methods to A{\beta}(1-40) and Curli fibrils and obtained results in good agreement with experiments.Comment: 13 pages, 8 figures, accepted to J. Chem. Phy