Some synthetic applications of dri-kri-substituted indolines generated via zirconocene-stabilized benzyne complexes

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.Includes bibliographical references.by John Liamanto.M.S

Jantung kuat bernapas lega : bagaimana memelihara kesehatan jantung dan sistem pernapasan anda

Judul asli: family medical care (Vol.3)430 p. : il.; 24 cm

Jantung kuat bernapas lega : bagaimana memelihara kesehatan jantung dan sistem pernapasan anda/ Knight

430 hal. : ill. ; 24 c

Jantung kuat bernapas lega : bagaimana memelihara kesehatan jantung dan sistem pernapasan anda

Judul asli: family medical care (Vol.3)430 p. : il.; 24 cm

Jantung kuat bernapas lega: bagaimana memelihara kesehatan jantung dan sistem pernapasan anda

430 hlm. : ilus. ; 25 cm

Promotion of a Ti-Mediated Mannich Reaction by a Proton Source

Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxazolidone-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a proton source. While various protic additives could be used to promote the transformation, the best results were obtained using AcOH to afford the corresponding Mannich products in high diastereoselectivities and yields

Promotion of a Ti-Mediated Mannich Reaction by a Proton Source

Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxazolidone-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a proton source. While various protic additives could be used to promote the transformation, the best results were obtained using AcOH to afford the corresponding Mannich products in high diastereoselectivities and yields

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

Process development of the synthesis of the orally active poly­(ADP-ribose)­polymerase inhibitor niraparib is described. Two new asymmetric routes are reported, which converge on a high-yielding, regioselective, copper-catalyzed <i>N</i>-arylation of an indazole derivative as the late-stage fragment coupling step. Novel transaminase-mediated dynamic kinetic resolutions of racemic aldehyde surrogates provided enantioselective syntheses of the 3-aryl-piperidine coupling partner. Conversion of the C–N cross-coupling product to the final API was achieved by deprotection and salt metathesis to isolate the desired crystalline salt form