126 research outputs found
DISCUSSION: MORAL RESPONSIBILITY IN AGRICULTURAL RESEARCH
Teaching/Communication/Extension/Profession,
FINANCIAL INTERMEDIATION IN AGRICULTURE: A SUGGESTED ANALYTICAL MODEL
Agricultural Finance,
Economics of western range resource use
This material was digitized as part of a cooperative project between the Society for Range Management and the University of Arizona Libraries.The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202
ECONOMIC AND EPIDEMIOLOGIC POLICY IMPLICATIONS OF ALTERNATIVE BOVINE BRUCELLOSIS PROGRAMS
This paper analyzes policy implications arising from the National Brucellosis Technical Commission Study. A systems simulation model was designed to estimate physical losses resulting from alternative bovine brucellosis programs. Changes in benefits, costs, level of infection and net benefits were calculated by program alternatives for determining economic and epidemiologic implications. Results indicate all alternative programs considered yield positive net benefits and reduce the prevalence of the disease. The results imply a need for further research to determine a program that is both epidemiologically and economically optimal.Livestock Production/Industries,
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Investigation and analysis of new-build housing defects during the initial ten years after occupation: a learning perspective
Rapid growth in the production of new homes in the United Kingdom (UK) is putting
build quality under pressure as evidenced by the increase in the number of defects.
Housing associations (HAs) contribute 21% to the UK’s annual supply of new
homes. HAs are experiencing the challenge of government funding cuts and rental
revenue reductions. Maximising the benefit of learning from defects is recognised as
being a key opportunity for HAs to help address these challenges. Learning from
defects is argued as a means of reducing the persistent defect problem within UK
house building, yet how HAs learn from defects is under-researched. There is also a
lack of research exploring which impacts of defects are perceived as important by
the key stakeholders, which has caused confusion over which types of defect HAs
should focus their learning on. The aim of this research was to better understand
how UK HAs, in practice, learn from past defects to reduce the prevalence of defects
in future new homes. The theoretical lens for this research was organisational
learning (OL).
An action research approach consisting of diagnosis, action planning, action taking,
action evaluation and specifying learning was adopted. Further, the principles of soft
systems methodology were incorporated in the action planning phase in order to
explore an ill-structured real world problem to identify desirable and feasible changes
(action interventions) within a HA. Data collection consisted of questionnaires, semistructured
interviews, a focus group and organisational documents. Data analysis
techniques included thematic analysis and simple statistical analysis.
The key findings suggested that OL can potentially reduce defects and revealed that
the health and safety implications and home occupant disruption caused by defects
are the priorities. OL in HAs appeared to be viewed as a secondary task which
consisted of a defects management team capturing and analysing defect data to
identify improvement opportunities, with a primary focus on designing out the
identified defects. Opportunities for data analysis fluctuated with workload. The use
of live data analysis protected against workload spikes. The key findings further
enabled the development of a specific OL from defects model for HAs. The findings
revealed the importance of a dual approach to learning consisting of a codification approach of designing out defects combined with a personalisation approach of
networking to tackle workmanship and other defects that can’t be designed out. The
practical challenges of AR were highlighted when the interventions were abandoned
due to changes in key personnel, despite the changes of a live data dashboard being
shown to be beneficial after implementation
Human Factors Certification of Advanced Aviation Technologies
Proceedings of the Human Factors Certification of Advanced Aviation Technologies Conference held at the Chateau de Bonas, near Toulouse, France, 19-23 July 1993
Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study
BACKGROUND: Eczema is a prevalent skin disease that is mainly characterized by systemic deviation of immune response and defective epidermal barrier. Th2 cytokines, such as IL-13, and transcription factor STAT6 are key elements in the inflammatory response that characterize allergic disorders, including eczema. Previous genetic association studies showed inconsistent results for the association of single nucleotide polymorphisms (SNPs) with eczema. Our aim was to investigate whether SNPs in IL13 and STAT6 genes, which share a biological pathway, have an interactive effect on eczema risk.METHODS: Data from two independent population-based studies were analyzed, namely the Isle of Wight birth cohort study (IOW; n = 1,456) and for the purpose of replication the Swansea PAPA (Poblogaeth Asthma Prifysgol Abertawe; n = 1,445) cross-sectional study. Log-binomial regressions were applied to (i) account for the interaction between IL13 (rs20541) and STAT6 (rs1059513) polymorphisms and (ii) estimate the combined effect, in terms of risk ratios (RRs), of both risk factors on the risk of eczema.RESULTS: Under a dominant genetic model, the interaction term [IL13 (rs20541) x STAT6 (rs1059513)] was statistically significant in both studies (IOW: adjusted Pinteraction = 0.046; PAPA: Pinteraction = 0.037). The assessment of the combined effect associated with having risk genotypes in both SNPs yielded a 1.52-fold increased risk of eczema in the IOW study (95% confidence interval (CI): 1.05 -- 2.20; P = 0.028) and a 2.01-fold higher risk of eczema (95% CI: 1.29 -- 3.12; P = 0.002) in the PAPA study population.CONCLUSIONS: Our study adds to the current knowledge of genetic susceptibility by demonstrating for the first time an interactive effect between SNPs in IL13 (rs20541) and STAT6 (rs1059513) on the occurrence of eczema in two independent samples. Findings of this report further support the emerging evidence that points toward the existence of genetic effects that occur via complex networks involving gene-gene interactions (epistasis)
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