126 research outputs found

    DISCUSSION: MORAL RESPONSIBILITY IN AGRICULTURAL RESEARCH

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    Teaching/Communication/Extension/Profession,

    Economics of western range resource use

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    This material was digitized as part of a cooperative project between the Society for Range Management and the University of Arizona Libraries.The Journal of Range Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202

    Emergency Livestock Line of Credit Guarantees.

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    2 p

    ECONOMIC AND EPIDEMIOLOGIC POLICY IMPLICATIONS OF ALTERNATIVE BOVINE BRUCELLOSIS PROGRAMS

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    This paper analyzes policy implications arising from the National Brucellosis Technical Commission Study. A systems simulation model was designed to estimate physical losses resulting from alternative bovine brucellosis programs. Changes in benefits, costs, level of infection and net benefits were calculated by program alternatives for determining economic and epidemiologic implications. Results indicate all alternative programs considered yield positive net benefits and reduce the prevalence of the disease. The results imply a need for further research to determine a program that is both epidemiologically and economically optimal.Livestock Production/Industries,

    Emergency Livestock Line of Credit Guarantees.

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    2 p

    Human Factors Certification of Advanced Aviation Technologies

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    Proceedings of the Human Factors Certification of Advanced Aviation Technologies Conference held at the Chateau de Bonas, near Toulouse, France, 19-23 July 1993

    Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study

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    BACKGROUND: Eczema is a prevalent skin disease that is mainly characterized by systemic deviation of immune response and defective epidermal barrier. Th2 cytokines, such as IL-13, and transcription factor STAT6 are key elements in the inflammatory response that characterize allergic disorders, including eczema. Previous genetic association studies showed inconsistent results for the association of single nucleotide polymorphisms (SNPs) with eczema. Our aim was to investigate whether SNPs in IL13 and STAT6 genes, which share a biological pathway, have an interactive effect on eczema risk.METHODS: Data from two independent population-based studies were analyzed, namely the Isle of Wight birth cohort study (IOW; n = 1,456) and for the purpose of replication the Swansea PAPA (Poblogaeth Asthma Prifysgol Abertawe; n = 1,445) cross-sectional study. Log-binomial regressions were applied to (i) account for the interaction between IL13 (rs20541) and STAT6 (rs1059513) polymorphisms and (ii) estimate the combined effect, in terms of risk ratios (RRs), of both risk factors on the risk of eczema.RESULTS: Under a dominant genetic model, the interaction term [IL13 (rs20541) x STAT6 (rs1059513)] was statistically significant in both studies (IOW: adjusted Pinteraction = 0.046; PAPA: Pinteraction = 0.037). The assessment of the combined effect associated with having risk genotypes in both SNPs yielded a 1.52-fold increased risk of eczema in the IOW study (95% confidence interval (CI): 1.05 -- 2.20; P = 0.028) and a 2.01-fold higher risk of eczema (95% CI: 1.29 -- 3.12; P = 0.002) in the PAPA study population.CONCLUSIONS: Our study adds to the current knowledge of genetic susceptibility by demonstrating for the first time an interactive effect between SNPs in IL13 (rs20541) and STAT6 (rs1059513) on the occurrence of eczema in two independent samples. Findings of this report further support the emerging evidence that points toward the existence of genetic effects that occur via complex networks involving gene-gene interactions (epistasis)
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