2,922 research outputs found

    The Lebesgue Universal Covering Problem

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    In 1914 Lebesgue defined a "universal covering" to be a convex subset of the plane that contains an isometric copy of any subset of diameter 1. His challenge of finding a universal covering with the least possible area has been addressed by various mathematicians: Pal, Sprague and Hansen have each created a smaller universal covering by removing regions from those known before. However, Hansen's last reduction was microsopic: he claimed to remove an area of 6⋅10−186 \cdot 10^{-18}, but we show that he actually removed an area of just 8⋅10−218 \cdot 10^{-21}. In the following, with the help of Greg Egan, we find a new, smaller universal covering with area less than 0.84411530.8441153. This reduces the area of the previous best universal covering by a whopping 2.2⋅10−52.2 \cdot 10^{-5}.Comment: 11 pages, 5 jpeg figures, numerical errors correcte

    Benchmark Calculations for Perchlorate from Three Human Cohorts

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    The presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. In a recently published report, the National Academy of Sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-day for months or longer. In this study, we calculated benchmark doses for perchlorate from thyroid-stimulating hormone (TSH) and free thyroxine (T(4)) serum indicators from two occupational cohorts with long-term exposure to perchlorate, and from a clinical study of volunteers exposed to perchlorate for 2 weeks. The benchmark dose for a particular serum indicator was defined as the dose predicted to cause an additional 5 or 10% of persons to have a serum measurement outside of the normal range. Using the data from the clinical study, we estimated the half-life of perchlorate in serum at 7.5 hr and the volume of distribution at 0.34 L/kg. Using these estimates and measurements of perchlorate in serum or urine, doses in the occupational cohorts were estimated and used in benchmark calculations. Because none of the three studies found a significant effect of perchlorate on TSH or free T(4), all of the benchmark dose estimates were indistinguishable from infinity. The lower 95% statistical confidence limits on benchmark doses estimated from a combined analysis of the two occupational studies ranged from 0.21 to 0.56 mg/kg-day for free T(4) index and from 0.36 to 0.92 mg/kg-day for TSH. Corresponding estimates from the short-term clinical study were within these ranges
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