A Selective Approach to Bleeding Esophageal Varices

It is possible that the best results of treatment for bleeding esophageal varices will come when a selective approach is used. In patients bleeding acutely and in patients with poor liver function shunt operations should be avoided, and a direct attack on the varices with either sclerosant therapy, percutaneous obliteration, or staple gun gastro-esophageal transsection should be carried out. In patients who have stopped bleeding, or those in whom elective treatment is being undertaken, the best operation at present appears to be selective distal splenorenal shunt

Development and Validation of Molecular Markers for \u3cem\u3ePhytophthora medicaginis\u3c/em\u3e Resistance in Lucerne

Resistance to Phytophthora medicaginis is an essential attribute to incorporate into lucerne (Medicago sativa) cultivars which are likely to be grown on heavy soils or in conditions where the soil remains excessively wet for prolonged periods. Current breeding strategies rely on recurrent phenotypic selection to maintain adequate levels of resistance in newly developed synthetic cultivars. However, little is known about the source or mechanism(s) of genetic resistance operating in the cultivar. A genetic linkage map was generated from a tetraploid M. sativa population using SSR markers anchored to existing genetic and physical maps. Large effect QTL were identified on linkage groups 2, 5, 6 and 7, each of which contributed between 11-30% of the phenotypic variation. Evaluation of the marker-trait associations in another sampling of the same population was undertaken, using a different isolate of P. medicaginis. The findings indicate that in the lucerne genotype examined in this study, a network of interactions involving at least three common loci, contribute to resistance to P. medicaginis. An alignment of the resistance loci identified in this study with those previously identified provided a framework for cataloguing the diversity of resistance loci present in lucerne, and will be used to guide future lucerne breeding efforts

Spatial Variations of Jovian Tropospheric Ammonia via Ground-Based Imaging

Optical bandpass-filter observations can be simply processed to determine similar horizontal ammonia distributions above the Jovian cloud tops as mid-infrared and microwave observations. Current understanding of this distribution and its relationship to aerosol opacity, cloud-top pressure, and circulation is provided by atmospheric retrieval models using observations from major ground-based facilities and spacecraft. These techniques recover high fidelity information on the ammonia distribution but are limited in spatial and temporal coverage. Part of this coverage gap - upper tropospheric abundance - can be bridged by using continuum-divided ammonia and methane absorption images as suggested by Combes and Encrenaz [1979]. In 2020-21, Jupiter was imaged in the 645 nm ammonia absorption band and adjacent continuum bands, demonstrating that the spatially-resolved optical depth in that band could be determined with a 0.28-m Schmidt-Cassegrain telescope (SCT). In 2022, a 620 nm filter was added to include methane absorption images in the same wavelength range. Methane abundance provides a constant reference against which to determine the ammonia abundance, specifically the column-averaged mole fraction above the clouds. VLT/MUSE results are compared to these SCT results and those from the TEXES mid-infrared spectrometer used on the IRTF and the Gemini telescopes. Meridional and longitudinal features are examined, including the Equatorial Zone (EZ) ammonia enhancement, the North Equatorial Belt (NEB) depletion, depletion above the Great Red Spot (GRS), and suggested enhancements over bright plumes in the northern EZ. This work demonstrates meaningful ammonia monitoring that can provide synoptic coverage and continuity between spacecraft or major ground-based facility campaigns.Comment: 23 pages, 8 figure

Pure dephasing in flux qubits due to flux noise with spectral density scaling as 1/fα1/ f^\alpha

For many types of superconducting qubits, magnetic flux noise is a source of pure dephasing. Measurements on a representative dc superconducting quantum interference device (SQUID) over a range of temperatures show that $S_\Phi(f) = A^2/(f/1 \hbox{Hz})^\alpha$, where $S_\Phi$ is the flux noise spectral density, $A$ is of the order of 1 $\mu\Phi_0 \, \hbox{Hz}^{-1/2}$ and $0.61 \leq \alpha \leq 0.95$; $\Phi_{0}$ is the flux quantum. For a qubit with an energy level splitting linearly coupled to the applied flux, calculations of the dependence of the pure dephasing time $\tau_\phi$ of Ramsey and echo pulse sequences on $\alpha$ for fixed $A$ show that $\tau_\phi$ decreases rapidly as $\alpha$ is reduced. We find that $\tau_\phi$ is relatively insensitive to the noise bandwidth, $f_1 \leq f \leq f_2$, for all $\alpha$ provided the ultraviolet cutoff frequency $f_2 > 1/\tau_\phi$. We calculate the ratio $\tau_{\phi,E} / \tau_{\phi,R}$ of the echo ($E$) and Ramsey ($R$) sequences, and the dependence of the decay function on $\alpha$ and $f_2$. We investigate the case in which $S_\Phi(f_0)$ is fixed at the "pivot frequency" $f_0 \neq 1$ Hz while $\alpha$ is varied, and find that the choice of $f_0$ can greatly influence the sensitivity of $\tau_{\phi,E}$ and $\tau_{\phi,R}$ to the value of $\alpha$. Finally, we present calculated values of $\tau_\phi$ in a qubit corresponding to the values of $A$ and $\alpha$ measured in our SQUID.Comment: 7 pages, 8 figures, 1 tabl

Excavations at the Bluff Creek Sites: 41MK10 and 41MK27, McColloch County, Texas

From late 1978 through early 1979, Ann M. Irwin of the Texas Department of Transportation (TxDOT) supervised excavations of two prehistoric archeological sites, 41MK10 and 41MK27, that were to be affected by construction along FM 765 in McCulloch County, Texas. The sites are located on Bluff Creek in the northern part of McCulloch County. Analyses of sites 41MK10 and 41MK27 and their cultural materials were conducted by TxDOT personnel in 1979, and an initial draft form of the report was prepared by Irwin in the early 1980s. TxDOT subsequently contracted SWCA, Inc. Environmental Consultants in 1999 to complete the report of the results of archeological investigations at 41MK10 and 41MK27 and to prepare the artifacts and records for curation. Site 41MK27 contained a small burned rock midden, Feature I. This midden was approximately 8 to 10 m in diameter, and 50 cm thick, and annular in form. A single internal feature (Feature IA), a rock-lined pit or hearth, was located in the approximate center and bottom of the midden. Lying between the midden and Bluff Creek were a series of small hearths, of which eight were excavated and designated as Features III through X. These small hearths, most of which had been at least somewhat disturbed, appeared to have been simple structures composed of one or more layers of rock. Many of the individual rocks appear to have been fire-fractured in place. No true basin-shaped hearths were observed. Associated with these hearths were an accompanying scatter of living debris in the form of flint and burned rock and significant quantities of freshwater mussel shell. Although the individual specimens are relatively small, the quantities recovered suggest that they served as a source of food. Radiocarbon data suggest that the site was intermittently occupied from the Late Archaic through the Late Prehistoric. The midden apparently dates to the Late Prehistoric, although the Transitional Archaic period may have been the period of most intense occupation at the site. Site 41MK10 was smaller than 41MK27 and not as intensively investigated. Two small burned rock features were excavated. The site was at least visited in the Late Archaic times, as is evidenced by the presence of a Castroville point, and in the Transitional Archaic, indicated by the recovery of two Ensor projectile points. It is likely, though by no means firmly established, that these dart point types are in fact associated with the use of the features

A Sample of Very Young Field L Dwarfs and Implications for the Brown Dwarf "Lithium Test" at Early Ages

Using a large sample of optical spectra of late-type dwarfs, we identify a subset of late-M through L field dwarfs that, because of the presence of low-gravity features in their spectra, are believed to be unusually young. From a combined sample of 303 field L dwarfs, we find observationally that 7.6+/-1.6% are younger than 100 Myr. This percentage is in agreement with theoretical predictions once observing biases are taken into account. We find that these young L dwarfs tend to fall in the southern hemisphere (Dec < 0 deg) and may be previously unrecognized, low-mass members of nearby, young associations like Tucana-Horologium, TW Hydrae, beta Pictoris, and AB Doradus. We use a homogeneously observed sample of roughly one hundred and fifty 6300-10000 Angstrom spectra of L and T dwarfs taken with the Low-Resolution Imaging Spectrometer at the W. M. Keck Observatory to examine the strength of the 6708-A Li I line as a function of spectral type and further corroborate the trends noted by Kirkpatrick et al. (2000). We use our low-gravity spectra to investigate the strength of the Li I line as a function of age. The data weakly suggest that for early- to mid-L dwarfs the line strength reaches a maximum for a few 100 Myr, whereas for much older (few Gyr) and much younger (<100 Myr) L dwarfs the line is weaker or undetectable. We show that a weakening of lithium at lower gravities is predicted by model atmosphere calculations, an effect partially corroborated by existing observational data. Larger samples containing L dwarfs of well determined ages are needed to further test this empirically. If verified, this result would reinforce the caveat first cited in Kirkpatrick et al. (2006) that the lithium test should be used with caution when attempting to confirm the substellar nature of the youngest brown dwarfs.Comment: 73 pages with 22 figures; to appear in ApJ (Dec 20, 2008, v689n2 issue

Low Temperature Opacities

Previous computations of low temperature Rosseland and Planck mean opacities from Alexander & Ferguson (1994) are updated and expanded. The new computations include a more complete equation of state with more grain species and updated optical constants. Grains are now explicitly included in thermal equilibrium in the equation of state calculation, which allows for a much wider range of grain compositions to be accurately included than was previously the case. The inclusion of high temperature condensates such as Al$_2$O$_3$ and CaTiO$_3$ significantly affects the total opacity over a narrow range of temperatures before the appearance of the first silicate grains. The new opacity tables are tabulated for temperatures ranging from 30000 K to 500 K with gas densities from 10$^{-4}$ g cm$^{-3}$ to 10$^{-19}$ g cm$^{-3}$. Comparisons with previous Rosseland mean opacity calculations are discussed. At high temperatures, the agreement with OPAL and Opacity Project is quite good. Comparisons at lower temperatures are more divergent as a result of differences in molecular and grain physics included in different calculations. The computation of Planck mean opacities performed with the opacity sampling method are shown to require a very large number of opacity sampling wavelength points; previously published results obtained with fewer wavelength points are shown to be significantly in error. Methods for requesting or obtaining the new tables are provided.Comment: 39 pages with 12 figures. To be published in ApJ, April 200

Influence of antigen distribution on the mediation of immunological glomerular injury

Influence of antigen distribution on the mediation of immunological glomerular injury. To determine if the site of immune reaction could influence the mediation and morphological expression of glomerular injury in experimental anti-glomerular basement membrane (anti-GBM) nephritis and membranous nephropathy, we studied the events that followed the in situ reaction of rat antibody with antigen planted in either the GBM (especially the lamina rara interna) or in the subepithelial space (SE). Non-nephritogenic amounts of noncomplement-fixing sheep anti-GBM or anti-tubular brushborder antibody were injected into separate groups of rats to plant sheep IgG in the GBM and SE, respectively. Kidneys containing sheep IgG were then transplanted into naive recipients that were passively immunized with rat anti-sheep IgG. There was marked proteinuria after 2 days (antigen in GBM: 226 ± 50.7; antigen in SE: 69 ± 50.7 mg/24 hr) that was abrogated by prior depletion of complement in both groups (antigen in GBM: 10.2 ± 1.7; antigen in SE: 14.3 ± 8.7 mg/24 hr). When antigen was planted in SE, inflammatory-cell depletion with either anti-neutrophil (PMN) serum or lethal irradiation had no effect on proteinuria. In contrast, anti-PMN abolished proteinuria (12.0 ± 5.6 mg/24 hr) and irradiation reduced it by 60% when antigen was in GBM. Glomeruli of kidneys with antigen in GBM were significantly larger and more hypercellular than those with antigen in SE after transplantation into immunized recipients. Endothelial cell injury and adherence of inflammatory cells to denuded GBM were prominent in the former (antigen in GBM), while glomeruli with antigen in SE showed only subepithelial deposits, adjacent slit-diaphragm displacement, and epithelial cell foot-process effacement. Thus, the reaction of antigen and antibody in glomeruli produced complement-mediated injury which was cell-independent when complex formation occurred on the outer aspect of the GBM but was cell-dependent when the same reagents reacted more proximally to the circulation. We therefore conclude that antigen distribution can critically influence the mediation and morphologic expression of immune glomerular injury and may, in part, account for variations in the clinical and histological manifestations of antibody-induced glomerular disease in humans.Influence de la distribution antigénique sur la médiation des lésions glomérulaires immunologiques. Afin de déterminer si le site de la réaction immune pourrait influencer la médiation et l'expression morphologique des lésions glomérulaires lors d'une néphrite expérimentale anti-membrane basale glomérulaire (anti-GBM) et d'une néphropathie extra-membraneuse, nous avons étudié les événements qui suivaient la réaction in situ d'anticorps de rat avec un antigène fixé soit dans la GBM (surtout dans la lamina rara interna), soit dans l'espace sous-épithélial (SE). Des quantités non nephritogènes d'anticorps anti-GBM, ou anti-bordure en brosse tubulaire de mouton ne fixant pas le complément ont été injectées à différents groupes de rats pour fixer de l'IgG de mouton dans la GBM et le SE, respectivement. Les reins contenant l'IgG de mouton étaient alors transplantés à des receveurs vierges passivement immunisés avec de l'IgG de rat antimouton. Il existait une protéinurie marquée après deux jours (antigène dans la GBM: 226 ± 50,7; antigène dans SE: 69 ± 50,7 mg/24 hrs) qui à été abrogé par une déplétion du complement dans les deux groupes (antigène dans la GBM: 10,2 ± 1,7; antigène dans SE: 14,3 ± 8,7 mg/24 hr). Lorsque l'antigène était fixé dans SE, une déplétion en cellules inflammatoires par du sérum anti-neutrophile (PMN) ou une irradiation léthale n'avaient pas d'effet sur la protéinurie. A l'opposé, anti-PMN supprimait la protéinurie (12,0 ± 5,6 mg/24 hr) et l'irradiation la réduisait de 60% lorsque l'antigène était dans la GBM. Les glomérules de reins ayant l'antigène dans la GBM étaient significativement plus gros et plus hyper-cellulaires que ceux ayant l'antigène dans SE après transplantation chez des receveurs immunisés. Les lésions cellulaires endothéliales et l'adhérence des cellules inflammatoires à des GBM nues étaient prédominantes chez les premiers (antigène dans la GBM) alors que les glomérules ayant l'antigène dans SE présentaient uniquement des dépôts sous-épithéliaux, un déplacement du slit-diaphragme adjacent et un effacement des pédicelles des cellules épithéliales. Ainsi, la réaction d'un antigène et d'un anticorps dans des glomérules a produit des lésions à médiation complémentaire indépentantes des cellules lorsque la formation de complexes survenait dans la partie extérieure de la GBM, mais dépendantes des cellules lorsque les mêmes réactifs interagissaient de façon plus proximale dans la circulation. Nous concluons donc que la distribution antigénique peut influencer de manière critique la médiation et l'expression morphologique des lésions glomérulaires immunes et qu'elle peut, en partie, rendre compte de variations dans les manifestations cliniques et histologiques de glomérulopathies à médiation par anticorps chez l'homme

The Lantern Vol. 18, No. 3, Spring 1950

• The Rise and Fall of Mr. Fluff • Thoughts by the Sea • Equality of Men • On Radio Comedians • After Hours • Rain • Morning • Escape from Fear • Book of Red • Poems by a Guy Named Mike • We are the People • Spirit Disrupted • Light • Sonnethttps://digitalcommons.ursinus.edu/lantern/1051/thumbnail.jp

Evidence for dark energy from the cosmic microwave background alone using the Atacama Cosmology Telescope lensing measurements

For the first time, measurements of the cosmic microwave background radiation (CMB) alone favor cosmologies with $w=-1$ dark energy over models without dark energy at a 3.2-sigma level. We demonstrate this by combining the CMB lensing deflection power spectrum from the Atacama Cosmology Telescope with temperature and polarization power spectra from the Wilkinson Microwave Anisotropy Probe. The lensing data break the geometric degeneracy of different cosmological models with similar CMB temperature power spectra. Our CMB-only measurement of the dark energy density $\Omega_\Lambda$ confirms other measurements from supernovae, galaxy clusters and baryon acoustic oscillations, and demonstrates the power of CMB lensing as a new cosmological tool.Comment: 4 pages, 3 figures; replaced with version accepted by Physical Review Letters, added sentence on models with non-standard primordial power spectr