1 research outputs found
Application of the Solid-Supported Glaser–Hay Reaction to Natural Product Synthesis
The Glaser–Hay coupling of
terminal alkynes is a useful
synthetic reaction for the preparation of polyynes; however, chemoselectivity
issues have precluded its widespread utilization. Conducting the reaction
on a solid-support provides a mechanism to alleviate the chemoselectivity
issues and provide products in high purities and yields. Moreover,
the polyyne core is a key component to several natural products. Herein,
we describe the application of a solid-supported Glaser–Hay
reaction in the preparation of several natural products. These compounds
were then screened for antibacterial activity, illustrating the utility
of the methodology