Location, Firm Size and International Trade: Simultaneous Measurement of the Effects of Internal and External Scale Economies on Exporting

International Relations/Trade,

Exploring the Cost Effectiveness of Land Conservation Auctions and Payment Policies

Until recently public efforts to encourage conservation on private land in many countries has primarily been through uniform payment policies. Auctions are increasingly used as a payment mechanism to acquire public benefits such as conservation actions that provide environmental improvements on private land (e.g. the US Conservation Reserve Program (CRP). The economic rationale for use of auctions is that they create decentralised incentives to offer bids at close to the true landholder opportunity costs, even when the implementing agency holds little information about these opportunity costs. This paper assesses the cost of a case study auction relative to four payment policies that use varying levels of information strategically to reduce rent payment and to prioritise funding based on environmental value. The results suggest that the estimated cost savings achievable with the discriminant price auction for conservation contracts depends on the policy to which the auction outcomes are compared. Auction cost savings are likely to be greatest when compared to policy alternatives involving little effort to discriminate amongst offers based on differences in landholder opportunity costs. A further key finding is that, for this case study, most of the savings resulting from the discriminant price auction could be attributed to the use of the environmental benefits index in project ranking and selection.Land Economics/Use,

Managing Saline Groundwater Impacts from Irrigation - Designing and Testing Emissions Trading in Coleambally Irrigation Area

Irrigated agriculture often leads to recharge to local and regional groundwater systems greater than what the systems can absorb, resulting in the development of shallow watertables causing salinity and waterlogging. Policy based on emissions trading offers one option for effective management of existing recharge externalities if effective property rights to diffuse emissions can be defined. In this paper we combine the conclusions drawn from biophysical research with economic principles underpinning emissions trading to present such a system. Allocation of net recharge contracts to irrigation farms will internalize the costs associated with saline aquifer impacts. Irrigators may reduce their compliance costs by creating or purchasing credits that reduce recharge through perennial vegetation, engineering solutions or crop rotation options. We discuss the economic impacts of adopting such a policy in the Coleambally Irrigation Area in southwestern New South Wales, Australia. We also demonstrate some of the conclusions drawn from our research using experimental economics.salinity, irrigation, recharge, tradeable emissions, cap and trade, hydrologic-economic modelling, experimental economics

Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization

Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue. Using confocal images, SpIDA generates fluorescence intensity histograms that are analysed by super-Poissonian distribution functions to obtain density and quantal brightness values of the fluorophore-labelled protein of interest. This allows both expression level and oligomerisation state of the protein to be determined. We describe the application of SpIDA to investigate the oligomeric state of G protein-coupled receptors (GPCRs) at steady state and following cellular challenge, and consider how SpIDA may be used to explore GPCR quaternary organisation in pathophysiology and to stratify medicines

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET

Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the muscarinic agonist carbachol but developed response to clozapine-N-oxide only upon induction of the RASSL. The two constructs co-localized at the plasma membrane and generated strong ratiometric fluorescence resonance energy transfer (FRET) signals consistent with direct physical interactions. Increasing levels of induction of the FRET-donor RASSL did not alter wild type receptor FRET-acceptor levels substantially. However, ratiometric FRET was modulated in a bell-shaped fashion with maximal levels of the donor resulting in decreased FRET. Carbachol, but not the antagonist atropine, significantly reduced the FRET signal. Cell surface homogenous time-resolved FRET, based on SNAP-tag technology and employing wild type and RASSL forms of the human M receptor expressed stably in Flp-In TREx 293 cells, also identified cell surface dimeric/oligomeric complexes. Now, however, signals were enhanced by appropriate selective agonists. At the wild type receptor large increases in FRET signal to carbachol and acetylcholine were concentration-dependent with EC values consistent with the relative affinities of the two ligands. These studies confirm the capacity of the human M muscarinic acetylcholine receptor to exist as dimeric/oligomeric complexes at the surface of cells and demonstrate that the organization of such complexes can be modified by ligand binding. However, conclusions as to the effect of ligands on such complexes may depend on the approach used

Weyl corrections to holographic conductivity

For conformal field theories which admit a dual gravitational description in anti-de Sitter space, electrical transport properties, such as conductivity and charge diffusion, are determined by the dynamics of a U(1) gauge field in the bulk and thus obey universality relations at the classical level due to the uniqueness of the Maxwell action. We analyze corrections to these transport parameters due to higher-dimension operators in the bulk action, beyond the leading Maxwell term, of which the most significant involves a coupling to the bulk Weyl tensor. We show that the ensuing corrections to conductivity and the diffusion constant break the universal relation with the U(1) central charge observed at leading order, but are nonetheless subject to interesting bounds associated with causality in the boundary CFT.Comment: 15 pages, v2: references adde

How Big is Big Enough? Firm Size as a Barrier to Exporting in South Carolina's Manufacturing Sector

International Relations/Trade,

Encouraging Revegetation in Australia with a Groundwater Recharge Credit Scheme

This paper describes a comprehensive method to design, test and then implement a Payments for Ecosystem Services (PES) framework to combat the environmental consequences of extensive native vegetation clearance in Australia. Clearing of vegetation, primarily due to the expansion of farming areas, has often resulted in regional dryland and irrigation salinity. The market based approach adopted ? a groundwater recharge credit trading scheme ? was designed using empirical data from a social survey and experimental economics. The objective of the trial is to test the cost effectiveness of an incentive based recharge credit trade scheme designed to engage landholders in establishing and managing deep rooted pasture and woody perennials to reduce these adverse salinity impacts. The scheme, based on a voluntary ?cap and trade? approach, allows farmers to meet recharge obligations by land management actions or by trading credits. Assessment of the scheme so far suggests that an incentive for aggregate group outcome achievement included in the design may have motivated higher enrollment rates than would have otherwise resulted. A schedule has been developed relating land management practices and recharge credits. The audited performance based payment system, has provided increased motivation to manage for environmental outcomes compared to the previous policy.Payments for Ecosystem Services (PES), market based instrument, cap and trade, salinity credit, revegetation, experimental economics

W49A North - Global or Local or No Collapse?

We attempt to fit observations with 5" resolution of the J=2-1 transition of CS in the directions of H II regions A, B, and G of W49A North as well as observations with 20" resolution of the J=2-1, 3-2, 5-4, and 7-6 transitions in the directions of H II regions A and G by using radiative transfer calculations. These calculations predict the intensity profiles resulting from several spherical clouds along the line of sight. We consider three models: global collapse of a very large (5 pc radius) cloud, localized collapse from smaller (1 pc) clouds around individual H II regions, and multiple, static clouds. For all three models we can find combinations of parameters that reproduce the CS profiles reasonably well provided that the component clouds have a core-envelope structure with a temperature gradient. Cores with high temperature and high molecular hydrogen density are needed to match the higher transitions (e.g. J=7-6) observed towards A and G. The lower temperature, low density gas needed to create the inverse P-Cygni profile seen in the CS J=2-1 line (with 5" beam) towards H II region G arises from different components in the 3 models. The infalling envelope of cloud G plus cloud B creates the absorption in global collapse, cloud B is responsible in local collapse, and a separate cloud, G', is needed in the case of many static clouds. The exact nature of the velocity field in the envelopes for the case of local collapse is not important as long as it is in the range of 1 to 5 km/s for a turbulent velocity of about 6 km/s. High resolution observations of the J=1-0 and 5-4 transitions of CS and C34S may distinguish between these three models. Modeling existing observations of HCO+ and C18O does not allow one to distinguish between the three models but does indicate the existence of a bipolar outflow.Comment: 42 pages, 27 figures, accepted for publication in the ApJS August 2004, v153 issu

Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs

Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown. Herein we address these topics for the M1 muscarinic acetylcholine receptor, a key molecular target for novel cognition enhancers, by employing Spatial Intensity Distribution Analysis. This method can measure fluorescent particle concentration and assess oligomerization states of proteins within defined regions of living cells. Imaging and analysis of the basolateral surface of cells expressing some 50 molecules.microm-2 of the human muscarinic M1 receptor identified an ~75/25 mixture of receptor monomers and dimers/oligomers. Both sustained and shorter-term treatment with the selective M1 antagonist pirenzepine resulted in a large shift in the distribution of receptor species to favor the dimeric/oligomeric state. Although sustained treatment with pirenzepine also resulted in marked upregulation of the receptor, simple mass-action effects were not the basis for ligand-induced stabilization of receptor dimers/oligomers. The related antagonist telenzepine also produced stabilization and enrichment of the M1 receptor dimer population but the receptor subtype non-selective antagonists atropine and N-methylscopolamine did not. In contrast, neither pirenzepine nor telenzepine altered the quaternary organization of the related M3 muscarinic receptor. These data provide unique insights into the selective capacity of receptor ligands to promote and/or stabilize receptor dimers/oligomers and demonstrate that the dynamics of ligand regulation of the quaternary organization of G protein-coupled receptors is markedly more complex than previously appreciated. This may have major implications for receptor function and behavior