Cox proportional hazards regression models of all-cause mortality over 8 years for IIV_RT (left side) and Mean RT (right side).

<p>Cox proportional hazards regression models of all-cause mortality over 8 years for IIV_RT (left side) and Mean RT (right side).</p

Baseline characteristics based on vital status at 8 years.

<p>Baseline characteristics based on vital status at 8 years.</p

Correlations between age, cognitive measures CVD risk score.

<p>Correlations between age, cognitive measures CVD risk score.</p

An image from the “Atlas for Stereotaxy of the Human Brain”: Schaltenbrand and Wahren, Plate 54 [25] showing a the stimulation target as red marker overlying the anteromedial pallidum on an axial brain slice at 3.5 mm below the AC/PC line.

<p>An image from the “Atlas for Stereotaxy of the Human Brain”: Schaltenbrand and Wahren, Plate 54 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104926#pone.0104926-Schaltenbrand1" target="_blank">[25]</a> showing a the stimulation target as red marker overlying the anteromedial pallidum on an axial brain slice at 3.5 mm below the AC/PC line.</p

Change in Total Yale Global Tic Severity Score (TYGTTS) at different time points pre and post-DBS.

<p>Bold line indicates the mean of the scores. Mean scores were only displayed when more than 3 data points were present. There was a downward trend or no change in the mean scores after 23 months.</p

Summary of individual patient characteristics.

1<p>including botulinum toxin.</p

Grey matter correlates of COWAT.

<p>Brain regions where voxel-based GM volumes are positively correlated with COWAT in 344 participants aged 70-90 years, are superimposed on the sagittal slices of the brain template. The slices are at 5 mm intervals between and including -80 mm and 75 mm. The colour bar represents the t score ranging from 0 to 5.5; and yellow indicates a higher t score than red. </p

Grey matter correlates of BNT.

<p>Brain regions where voxel-based GM volumes are positively correlated with BNT in 344 participants aged 70-90 years, superimposed on the sagittal slices of the brain template. The slices are at 4 mm intervals between and including -48 mm and 44 mm. The colour bar represents the t score ranging from 0 to 5.5; and yellow indicates a higher t score than red.</p

Grey matter correlates of CF.

<p>Brain regions where voxel-based GM volumes are positively correlated with CF in 344 participants aged 70-90 years, superimposed on the sagittal slices of the brain template. The slices are at 4 mm intervals between and including -48 mm and -20 mm. The colour bar represents the t score ranging from 0 to 5.5; and yellow indicates a higher t score than red.</p

Prevalence of mild cognitive impairment: subtypes, and as based on Clinical Dementia Ratings and Mini-Mental State Examination scores.

<p>aMCI = amnestic mild cognitive impairment; naMCI = non-amnestic mild cognitive impairment; CDR = Clinical Dementia Rating; MMSE = Mini-Mental State Examination; NA = not applicable. Values are percentage prevalence (95% confidence interval). The objective cognitive impairment criteria for these classifications was for aMCI: performance in the bottom 6.681% of the relevant study for the memory domain; naMCI: performance in the bottom 6.681% of the relevant study for at least one harmonized cognitive domain other than and excluding memory; CDR: a rating of 0.5; MMSE: a score of 24–27. Standardized prevalence estimates were directly standardized for age group and sex, with the standard population being the total sample of all studies included in the analysis; data were imputed for the missing age ranges within Invece.Ab, PATH and Sydney MAS.</p><p>Prevalence of mild cognitive impairment: subtypes, and as based on Clinical Dementia Ratings and Mini-Mental State Examination scores.</p