Lateglacial to Holocene palaeoenvironmental change in the Muck Deep, offshore western Scotland

Seismic unit classification in the Muck Deep, summary of the Muck Core Units described, core photos showing details of the sedimentary structures in cores 729 and 731 and Correlation between core 731 and MD6

Fjord systems and archives: a review

<p>Fjords are glacially over-deepened semi-enclosed marine basins, typically with entrance sills separating their deep waters from the adjacent coastal waters which restrict water circulation and thus oxygen renewal. The location of fjords is principally controlled by the occurrence of ice sheets, either modern or ancestral. Fjords are therefore geomorphological features that represent the transition from the terrestrial to the marine environment and, as such, have the potential to preserve evidence of environmental change. Typically, most fjords have been glaciated a number of times and some high-latitude fjords still possess a resident glacier. In most cases, glacial erosion through successive glacial/interglacial cycles has ensured the removal of sediment sequences within the fjord. Hence the stratigraphic record in fjords largely preserves a glacial-deglacial cycle of deposition over the last 18 ka or so. Sheltered water and high sedimentation rates have the potential to make fjords ideal depositional environments for preserving continuous records of climate and environmental change with high temporal resolution. In addition to acting as high-resolution environmental archives, fjords can also be thought of as mini-ocean sedimentary basin laboratories. Fjords remain an understudied and often neglected sedimentary realm. With predictions of warming climates, changing ocean circulation and rising sea levels, this volume is a timely look at these environmentally sensitive coastlines. </p

Fjord systems and archives: a review

<p>Fjords are glacially over-deepened semi-enclosed marine basins, typically with entrance sills separating their deep waters from the adjacent coastal waters which restrict water circulation and thus oxygen renewal. The location of fjords is principally controlled by the occurrence of ice sheets, either modern or ancestral. Fjords are therefore geomorphological features that represent the transition from the terrestrial to the marine environment and, as such, have the potential to preserve evidence of environmental change. Typically, most fjords have been glaciated a number of times and some high-latitude fjords still possess a resident glacier. In most cases, glacial erosion through successive glacial/interglacial cycles has ensured the removal of sediment sequences within the fjord. Hence the stratigraphic record in fjords largely preserves a glacial-deglacial cycle of deposition over the last 18 ka or so. Sheltered water and high sedimentation rates have the potential to make fjords ideal depositional environments for preserving continuous records of climate and environmental change with high temporal resolution. In addition to acting as high-resolution environmental archives, fjords can also be thought of as mini-ocean sedimentary basin laboratories. Fjords remain an understudied and often neglected sedimentary realm. With predictions of warming climates, changing ocean circulation and rising sea levels, this volume is a timely look at these environmentally sensitive coastlines. </p

Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry

Recent advances in understanding the relevance of noncoding RNA (ncRNA) to disease have increased interest in drugging ncRNA with small molecules. The recent discovery of ribocil, a structurally distinct synthetic mimic of the natural ligand of the flavin mononucleotide (FMN) riboswitch, has revealed the potential chemical diversity of small molecules that target ncRNA. Affinity-selection mass spectrometry (AS-MS) is theoretically applicable to high-throughput screening (HTS) of small molecules binding to ncRNA. Here, we report the first application of the Automated Ligand Detection System (ALIS), an indirect AS-MS technique, for the selective detection of small molecule–ncRNA interactions, high-throughput screening against large unbiased small-molecule libraries, and identification and characterization of novel compounds (structurally distinct from both FMN and ribocil) that target the FMN riboswitch. Crystal structures reveal that different compounds induce various conformations of the FMN riboswitch, leading to different activity profiles. Our findings validate the ALIS platform for HTS screening for RNA-binding small molecules and further demonstrate that ncRNA can be broadly targeted by chemically diverse yet selective small molecules as therapeutics