The correlation between MFC and HbA1c.

<p>The correlation between proton magnetic resonance spectroscopy measured muscle fat content (MFC) and glycosylated hemoglobin (HbA1c) in the 287 overweight/obese children and adolescents: R² = 0.07, <i>p</i> = 0.04.</p

Baseline characteristics of 287 overweight/obese (cases) and 40 lean (controls) children and adolescents.

<p>Data are presented as medians (interquartile range) due to a non-normal distribution. BMI, body mass index; diaBP, diastolic blood pressure; EMCL, extramyocellular lipid content; HbA1c, glycosylated hemoglobin; HDL, high density lipoprotein; HOMA-IR, homeostatic model assessment of insulin resistance; IMCL, intramyocellular lipid content; LDL, low density lipoprotein; LFC, liver fat content; MFC, muscle fat content; SAT, subcutaneous adipose tissue volume; SDS, standard deviation score; sysBP, systolic blood pressure; VAT, visceral adipose tissue volume.</p><p>Baseline characteristics of 287 overweight/obese (cases) and 40 lean (controls) children and adolescents.</p

The correlation between LFC and HbA1c.

<p>The correlation between proton magnetic resonance spectroscopy measured liver fat content (LFC) and glycosylated hemoglobin (HbA1c) in the 287 overweight/obese children and adolescents: R² = 0.09, <i>p</i> = 0.004.</p

Lead SNPs from the discovery-, replication- and meta-analyses.

<p>Lead SNPs from the discovery-, replication- and meta-analyses.</p

Association of genome-wide variants with plasma TSH concentrations.

<p>SNPs are plotted on the x-axis according to their chromosomal position against the–log10(<i>p</i>-value). The results were considered genome-wide significant with a <i>p</i><5·10⁻⁸. A threshold for replication was set at <i>p</i><1·10⁻⁶.</p

Association of genome-wide variants with plasma fT4 concentrations.

<p>SNPs that passed QC are plotted on the x-axis according to their chromosomal position against their–log10(<i>p</i>-value). The results were considered genome-wide significant with a <i>p</i><5·10⁻⁸ and a replication threshold was set at <i>p</i><1·10⁻⁶.</p

Effects of genetic variants known to associate with plasma TSH or fT4 concentrations.

<p>Effects from studies in adults compared to the effects of the variants in the cohort from the Danish Childhood Obesity Biobank (TDCOB). Effect sizes are shown in standard deviations (SD) of the rank-normalized TSH or fT4 distribution with 95% confidence intervals. EA is the Effect Allele (from the literature). I² is the measure for heterogeneity between the TDCOB cohort and literature. p(Hetro) is the p-value for the heterogeneity.</p