Additional file 1 of Proteins associated with incident metabolic syndrome in population-based cohorts

Additional file 1: Table S1. Relationships between the 86 evaluated proteins and the five components of the metabolic syndrome (MetS) in the cross-sectional evaluation in PIVUS. Odds ratio (OR) and 95% CI are geiven together with -pvalue for each ot the five components. GLU = glucose, BP = blood pressure, HDL = HDL-cholesterol, TG = triglycerides, WC = waist circumference. A p-value of 0 denotes a p-value < 10–7. The short names of the proteins are used in Fig. 4. Table S2. Relationships between the 86 evaluated proteins and the five components of the metabolic syndrome (MetS) in the cross-sectional evaluation in ULSAM. Odds ratio (OR) and 95% CI are given together with p-value for each of the five components. GLU = glucose, BP = blood pressure, HDL = HDL-cholesterol, TG = triglycerides, WC = waist circumference. A p-value of 0 denotes a p-value < 10–7. The short names of the proteins are used in Fig. 4. Table S3. Relationships between SNPs in the region of the genes for IL-1 alpha and beta on chromosome 2 and the metabolic syndrome (MetS) in UK biobank (Lind L. Metab Syndr Relat Disord. 2019;17:505-11)

Change in 84 proteins over 10-year follow-up with measurements at ages 70, 75 and 80 years.

Change in 84 proteins over 10-year follow-up with measurements at ages 70, 75 and 80 years.</p

Each model’s predictive power for incident cardiovascular disease.

Each model’s predictive power for incident cardiovascular disease.</p

The correlations between the measurements of left ventricular mass index at 70, 75, and 80 years of age.

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The correlations between the measurements of left ventricular end-diastolic diameter at 70, 75, and 80 years of age.

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Box plot showing the Normalized Protein eXpression (NPX) values for the 3 proteins showing the most significant increments over time and the protein showing the most significant decline over time.

U-PAR = Urokinase plasminogen activator surface receptor.</p

Additional file 3: of DNA methylation patterns associated with oxidative stress in an ageing population

Supplemental Tables. Table S1. Methylation sites associated with TGSH (FDR <0.05). Table S2. Methylation sites associated with GSH (FDR <0.05. Table S3. Methylation sites associated with GSSG (FDR <0.05). Table S4. Methylation sites associated with ratio of GSSG-to-GSH (FDR <0.05). Table S5. Methylation sites associated with levels of HCY (FDR <0.05). Table S6. Methylation sites associated with levels of oxLDL (FDR <0.05). Table S7. Methylation sites associated with levels of CD (FDR <0.05). Table S8: Methylation sites associated with BCD-LDL (FDR <0.05). (XLS 185 kb

Additional file 4: Figure S4. of DNA methylation patterns associated with oxidative stress in an ageing population

Overview of the analysis of genetic associations of oxidative stress-associated DNA methylation. The diagram shaded in blue depicts the associations at the two instances where we observed an overlap across genotype-CpG (FDR < 0.05), genotype-phenotype (p < 0.001), and CpG-phenotype (FDR < 0.05). (XLSX 60 kb

Fig 2 -

Spline functions for left atrial diameter (upper panel) and left ventricular ejection fraction (lower panel). The hazard ratio is represented by the black solid line and the 95% confidence intervals are represented by the dashed lines. A hazard ratio of 1 is indicated by the red horizontal line. CVD, cardiovascular disease.</p

The correlations between the measurements of N-terminal-pro hormone B-type natriuretic peptide at 70, 75, and 80 years of age.

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