Descriptive data on 106 consecutive patients with hemorrhagic fever with renal syndrome.

<p>Figure 1a represents median laboratory data and Figure 1b represents mean overt DIC-score.</p

Comparison between patient complications and presence of DIC according to overt- and non-overt DIC-score (≥5p and <5p respectively).

a<p>Bleeding of moderate/major importance.</p>b<p>Comparison between ≥5 and <5 points. P-value calculated with Fischer exact test and χ² test.</p

Comparison of laboratory and clinical parameters in patients with moderate/severe vs. mild hemorrhagic fever with renal syndrome.

a<p>Calculated using Mann-Whitney U and χ² test.</p>b<p>Value given as median, 25^th and 75^th percentiles within parentheses.</p>c<p>Value given as median, range within parentheses.</p>d<p>Value given as median, range within parentheses.</p>e<p>Median value at the day of DIC-scoring (n = 88).</p

Scoring templates for overt- and non-overt (NO) disseminated intravascular coagulation (DIC) in patients with hemorrhagic fever with renal syndrome.

<p>DIC1 and NO-DIC1 correspond to standard ISTH scoring using local decision limit. DIC—2 and NO-DIC-2 uses D-dimer cut-offs based on ICU-patients. DIC3-4 are corrected with a fibrinogen/CRP-ratio instead of fibrinogen.</p><p>The original ISTH SSC template uses “moderately” and “strongly” increased values for D-dimer cutoffs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021134#pone.0021134-Taylor1" target="_blank">[35]</a>. In this table laboratory cutoffs are set from local decision limits and also corrected with a fibrinogen/CRP ratio <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0021134#pone.0021134-Kim1" target="_blank">[37]</a>. Overt DIC-score ≥5p: compatible with overt DIC, <5p: suggestive for non-overt DIC.</p>a<p>D-dimer cutoff as in DIC1, fibrinogen corrected with fibrinogen/CRP-ratio.</p>b<p>D-dimer cutoff as in DIC2, fibrinogen corrected with fibrinogen/CRP-ratio.</p>c<p>PK-INR <1.2 was equal to PT-prolongation <3 sec, a value between 1.2 and 1.4 was equal to PT-prolongation >3 but <6 sec, and values >1.4 were equal to PT-prolongation >6 sec.</p

Baseline characteristics of the pregnant women.

<p>Data are presented as the means and standard deviation (SD) or proportions (%).</p

Plasma concentrations of 25(OH)D in women during pregnancy and after birth.

<p>Data are presented as the means and standard deviations (SD) or proportions (%) according to 25(OH)D category.</p

Results of the multivariate linear mixed model analyses of factors related to plasma concentrations of vitamin D in women during pregnancy and after birth.

<p>Results of the multivariate linear mixed model analyses of factors related to plasma concentrations of vitamin D in women during pregnancy and after birth.</p

Adipokines are possible risk markers for aortic stenosis requiring surgery

Aortic stenosis (AS) is the most prevalent valvular heart disease among adults. The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. We examined whether these adipokines are independently associated with future aortic valve replacement (AVR). In this longitudinal case-control study, we identified 336 cases who had undergone AVR due to AS, and who had previously participated in population-based health surveys. Two referents were matched to each case and leptin and adiponectin concentrations were analysed from stored baseline survey samples. Uni- and multivariable logistic regression analyses were used to estimate the risk of future AVR. An additional cohort was identified for validation including 106 cases with AVR and 212 matched referents. Median age (interquartile range (IQR)) in years at survey was 59.9 (10.4) and at surgery 68.3 (12.7), and 48% were women. An elevated concentration of leptin was not associated with future AVR (odds ratio [95% confidence interval]) (1.10 [0.92–1.32]), although leptin was associated with a higher risk in patients with coronary artery disease (CAD) having more than 5 years between survey and AVR (1.41 [1.08–1.84]). Adiponectin was not associated with higher risk for future AVR (0.95 [0.82–1.11]), although after stratification for age, higher levels were associated with reduced risk for AVR in persons aged ≥60 years at surgery (0.79 [0.64–0.98]). In the validation study, leptin was associated with future AVR whereas adiponectin was not. None of the associations remained significant after adjustment for body mass index (BMI). The adipokine leptin may promote the development of AS.</p

Correlations between leukocyte TL and hippocampal volume among <i>APOE</i> ε3/ε3 and <i>APOE</i> ε4 carriers.

<p>Leukocyte TL was adjusted for age. Hippocampal volume was adjusted for body (and head) size and age. Regression lines only shown for significant Spearman correlations.</p

General characteristics of study participants.

<p>All values are means unless otherwise stated. MMSE, Mini-mental state examination; SD, standard deviation.</p>a<p>Blood pressure ≥140/90 or taking antihypertensive medication.</p>b<p>Adjusted for body (and head) size and age.</p>c<p>Adjusted for age.</p