Additional file 1 of Proteins associated with incident metabolic syndrome in population-based cohorts

Additional file 1: Table S1. Relationships between the 86 evaluated proteins and the five components of the metabolic syndrome (MetS) in the cross-sectional evaluation in PIVUS. Odds ratio (OR) and 95% CI are geiven together with -pvalue for each ot the five components. GLU = glucose, BP = blood pressure, HDL = HDL-cholesterol, TG = triglycerides, WC = waist circumference. A p-value of 0 denotes a p-value < 10–7. The short names of the proteins are used in Fig. 4. Table S2. Relationships between the 86 evaluated proteins and the five components of the metabolic syndrome (MetS) in the cross-sectional evaluation in ULSAM. Odds ratio (OR) and 95% CI are given together with p-value for each of the five components. GLU = glucose, BP = blood pressure, HDL = HDL-cholesterol, TG = triglycerides, WC = waist circumference. A p-value of 0 denotes a p-value < 10–7. The short names of the proteins are used in Fig. 4. Table S3. Relationships between SNPs in the region of the genes for IL-1 alpha and beta on chromosome 2 and the metabolic syndrome (MetS) in UK biobank (Lind L. Metab Syndr Relat Disord. 2019;17:505-11)

sj-pdf-1-vmj-10.1177_1358863X231161655 – Supplemental material for Nondipping blood pressure pattern predicts cardiovascular events and mortality in patients with atherosclerotic peripheral vascular disease

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X231161655 for Nondipping blood pressure pattern predicts cardiovascular events and mortality in patients with atherosclerotic peripheral vascular disease by Nina Dahle, Johan Ärnlöv, Jerzy Leppert and Pär Hedberg in Vascular Medicine</p

Associations between the change in kidney function (glomerular filtration rate, GFR) and change in 84 prteins over time (regression coefficient) and the–log₁₀ p-value for these associations.

The Bonferroni-corrected p-value is shown as the horizontal line. The regression coefficient (beta) gives the relationship between the change in protein levels (on a SD-scale) vs the change in GFR (in mL/min/1.73m2).</p

Box plot showing the Normalized Protein eXpression (NPX) values for the 3 proteins showing the most significant increments over time and the protein showing the most significant decline over time.

U-PAR = Urokinase plasminogen activator surface receptor.</p

Change in 84 proteins over 10-year follow-up with measurements at ages 70, 75 and 80 years.

Change in 84 proteins over 10-year follow-up with measurements at ages 70, 75 and 80 years.</p

Effect sizes (regression coefficients) of changes of 84 proteins over time and the–log₁₀ p-value for corresponding changes.

The Bonferroni-corrected p-value is shown as the horizontal line. The regression coefficient (beta) gives the change per year on a SD-scale.</p

Relationships between the 15 validated metabolites being related to all five components in the metabolic syndrome (MetS) and fasting glucose (GLU), HDL-cholesterol, systolic blood pressure (SBP), triglycerides (TG) and waist circumference (WC).

The estimates are from the validation step in the SCAPIS-Malmö cohort. No relationship for the metabolite glucose vs the GLU criteria is shown. (DOCX)</p

Relationships between the 15 validated metabolites being related to all five components in the metabolic syndrome (MetS) and prevalent MetS in a meta-analysis of the PIVUS and POEM samples.

The results are sorted on p-value. A star following the p-value denotes that the metabolite shows a false discovery rate (FDR)<0.05.</p

Relationships between the 15 validated metabolites being related to all five components in the metabolic syndrome (MetS) and incident atherosclerotic cardiovascular disease in the EpiHealth cohort.

Relationships between the 15 validated metabolites being related to all five components in the metabolic syndrome (MetS) and incident atherosclerotic cardiovascular disease in the EpiHealth cohort.</p

Overview of the metabolites being associated with at least one of the five MetS criteria.

The criteria are given together with sum of criteria. The table was sorted on sum of criteria. (DOCX)</p