Low levels of nuclear ß-catenin coincide with high levels of E-cadherin in BCC.

<p><b>A.</b> Microphotographs of selected sample of ß-catenin, showing nuclear staining only at the periphery or the tumor. Bar = 200 µm. <b>B.</b> Microphotographs of selected sample of E-cadherin showing lowered expression of the tumor compared with the normal epidermis.</p

Sample characteristics.

*<p>FFPE =  Formalin-fixed, paraffin-embedded, FF =  Fresh- frozen.</p

Expression of SHH, APC, SFRP5 and RASSF1A is reduced in BCC versus healthy skin control tissue.

<p><b>A.</b> Relative expression levels of <i>APC</i> and <i>SFRP5 i</i>n BCC tissues as compared to the expression level in normal skin (n = 6) (2−^ΔΔCt). All reactions were done in triplicates, standard error of the mean (SEM) is shown as error bars. Expression levels were normalized to Cyclophilin A. U, unmethylated sample; M, methylated sample. *p≤0.05, **p≤0.001. <b>B.</b> Relative mRNA expression in unmethylated versus methylated BCC samples for either <i>APC</i> or <i>SFRP5. </i><b>C.</b> Microphotographs of selected samples of SHH, APC and RASSF1A. Bar = 200 µm.</p