452 research outputs found
Extraction and characterization of candidate bioactive compounds in different tissues from salmon (Salmo salar)
Perceptions and experiences of living with coexisting type 2 diabetes and severe mental illness:a scoping review
Parametric improvement for the ingestion dose module of the European ARGOS and RODOS decision support systems
The European decision support systems ARGOS and RODOS rely on the ECOSYS model for prognoses of ingestion doses. ECOSYS needs an update of various parameter values to provide reliable estimates. This paper reports on some results of a Nordic initiative to derive parameter values that are specific to Nordic conditions, as well as to improve generic parameter values in ECOSYS, taking into account the host of useful measurement data accumulated since ECOSYS was created
Tocilizumab for the Treatment of Mevalonate Kinase Deficiency
Mevalonate kinase deficiency (MKD) is a severe autoinflammatory disease caused by recessive mutations in MVK resulting in reduced function of the enzyme mevalonate kinase, involved in the cholesterol/isoprenoid pathway. MKD presents with periodic episodes of severe systemic inflammation, poor quality of life, and life-threatening sequelae if inadequately treated. We report the case of a 12-year-old girl with MKD and severe autoinflammation that was resistant to IL-1 and TNF-Îą blockade. In view of this, she commenced intravenous tocilizumab (8âmg/kg every 2 weeks), a humanised monoclonal antibody targeting the IL-6 receptor (IL-6R) that binds to membrane and soluble IL-6R, inhibiting IL-6-mediated signaling. She reported immediate cessation of fever and marked improvement in her energy levels following the first infusion; after the fifth dose, she was in complete clinical and serological remission, now sustained for 24 months. This is one of the first reported cases of a child with MKD treated successfully with tocilizumab and adds to the very limited experience of this treatment for MKD. IL-6 blockade could therefore be an important addition to the armamentarium for the treatment of this rare monogenic autoinflammatory disease
Optimizing omnidirectional reflection by multilayer mirrors
Periodic layered media can reflect strongly for all incident angles and
polarizations in a given frequency range. Quarter-wave stacks at normal
incidence are commonplace in the design of such omnidirectional reflectors. We
discuss alternative design criteria to optimize these systems.Comment: 9 pages, 6 figures. To be published in J. Opt. A: Pure and Applied
Optic
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