市民社会のプレーヤー交代劇と政治-仁平典宏の<贈与のパラドックス>論を読み解く-

千葉大学大学院人文社会科学研究科研究プロジェクト報告書第257集『都市コミュニティにおける相互扶助と次世代育成』水島治郎 編Sustainable Urban Communities: Communality and Generativity Report on the Research Projects No.25

Supplemental Data: A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Arterial Disease.

<div><div>Supplemental Data: </div><div>A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Arterial Disease. </div></div><div><br></div

Newly discovered protein-QTLs (10% FDR): protein probe and lead significant SNP.

<p>Newly discovered protein-QTLs (10% FDR): protein probe and lead significant SNP.</p

Locuszoom plot of MST1, CD and UC association pvalues around the MST1 gene.

<p>It is worth noting that our proteomics platform has 4 probes in this chromosomal region, targeting 4 different proteins: IMPDH2 (probe SL010928), MST1 (probe SL005202), MST1R (probe SL004637) and MAPKAPK3 (probe SL004765). Of these, MST1 is most significantly associated with the IBD GWAS SNP in this locus (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006565#pgen.1006565.s003" target="_blank">S3 Fig</a>), and the association pattern was highly consistent with the CD and UC GWAS peaks (Fig 5).</p

Overlaps between blood serum protein-QTLs and previously published eQTLs from several tissues (10% FDR).

<p>Overlaps between blood serum protein-QTLs and previously published eQTLs from several tissues (10% FDR).</p

Enrichment for GWAS signals in blood protein-QTLs of CD patients.

<p>Expected uniform -log10(relative rank) of the protein-SNPs (nominal pvalue ≤ 1E-5) within the full GWAS SNPs list on the horizontal axis; observed–log10(relative rank) on the vertical axis. CD: Crohn’s Disease; UC: Ulcerative Colitis; BMI: Body Mass Index; SCZ: Schizofrenia; Stroke: Ischemic Stroke; T2D: Type-2 Diabetes. References for all the studies are reported in the Methods section.</p

Increase of Albumin levels with aging in CD and UC.

<p>Scatterplot of the Albumin protein level vs patients age, separately for UC patients (left panel) and CD patients (baseline data only is displayed, right panel). Age in years on the horizontal axis; mean-centered and adjusted log2-protein expression on the vertical axis (adjusted for sex and plateID).</p

Additional file 3: Figure S1. of Development and clinical application of an integrative genomic approach to personalized cancer therapy

A decision tree approach to predict drug response based on genetic alterations. (PPTX 96 kb

Additional file 12: Figure S9A and B. of Development and clinical application of an integrative genomic approach to personalized cancer therapy

CLPB-NADSYN1 gene fusion in patient P0002. a Long-range PCR confirms CLPB-NADSYN1 gene fusion. b Genomic breakpoint of CLPB-NADSYN1 gene fusion. (ZIP 150 kb

Additional file 11: Figure S8. of Development and clinical application of an integrative genomic approach to personalized cancer therapy

A scatter plot of CCND1 gene expression versus log2 copy number ratio (tumor/normal). Each dot represents a patient tumor sample. Tumor types are color-coded. The two breast cancer patients where we reported CCND1 amplification are P0002 and P0040. (PPTX 112 kb