3 research outputs found
Cost-Effective Method to Perform SARS-CoV-2 Variant Surveillance: Detection of Alpha, Gamma, Lambda, Delta, Epsilon, and Zeta in Argentina
The emergence of SARS-CoV-2 variants with concerning characteristics to public health has attracted the attention of the scientific community and governments both regionally and globally since the end of 2020. The most relevant variants described so far include: Alpha (lineage B.1.1.7), first detected in the United Kingdom; Beta (lineage B.1.351), initially detected in South Africa; Gamma (lineage P.1), initially detected in Manaus, Brazil, and Japan; Delta (lineage B.1.627.2), initially detected in India; Lambda (lineage C.37), initially detected in Peru; Mu (lineage B.1.621), first detected in Colombia; Epsilon (lineages B.1.427 and B.1.429), initially detected in California, United States; and Zeta (lineage P.2), first detected in Rio de Janeiro, Brazil (1). Four of these variants (Alpha to Delta) have been defined as variants of concern (VOCs) given their increased transmissibility and other characteristics, while Lambda and Mu have been defined as variants of interest (VOIs). The VOCs have also been associated with an increased risk of hospitalization (2, 3) and, in the case of Beta, Gamma, and Delta, with a moderate to a substantial reduction in neutralizing activity of monoclonal antibodies, convalescent, and vaccine sera (4–6). Gamma and Lambda are particularly relevant for Argentina due to their major presence in the South American region during the time of this study.
Importantly, some of these variants share mutations in the Spike protein—several of them in the receptor-binding domain region—that potentially affect transmissibility, pathogenesis, and/or response to vaccination and immune-based therapies (7, 8).
PAIS is the interinstitutional federal consortium of SARS-CoV-2 genomics in Argentina. It was created by the Ministry of Science and Technology to monitor SARS-CoV-2 diversity and evolution in the country, including surveillance of SARS-CoV-2 variants of public health interest (http://pais.qb.fcen.uba.ar/).
The objective of this work was to implement a SARS-CoV-2 molecular surveillance strategy, in a context of limited resources, which allowed an assessment of the dynamic situation of circulation of viral variants, and at the same time, to perform genomic and evolutionary analyzes to study their origin and dispersion in our country.Instituto de PatologĂa VegetalFil: Torres, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de Investigaciones en BacteriologĂa y VirologĂa Molecular; ArgentinaFil: Torres, Carolina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Mojsiejczuk, Laura. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de Investigaciones en BacteriologĂa y VirologĂa Molecular; ArgentinaFil: Mojsiejczuk, Laura. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Acuña, Dolores. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Acuña, Dolores. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; ArgentinaFil: Alexay, SofĂa. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; ArgentinaFil: Amadio, Ariel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Amadio, Ariel. Instituto Nacional de TecnologĂa Agropecuaria (INTA). EstaciĂłn Experimental Agropecuaria Rafaela. Instituto de InvestigaciĂłn de la Cadena Láctea; ArgentinaFil: Aulicino, Paula. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Aulicino, Paula. Hospital de PediatrĂa “Prof. Juan P. Garrahan". Laboratorio de BiologĂa Celular y Retrovirus; ArgentinaFil: Debat, Humberto Julio. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de PatologĂa Vegetal; ArgentinaFil: Fay, Fabián. CIBIC Laboratorio; ArgentinaFil: Fernandez, Franco Daniel. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de PatologĂa Vegetal; ArgentinaFil: Giri, Adriana A. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Giri, Adriana A. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa Molecular y Celular de Rosario. Grupo VirologĂa Humana; ArgentinaFil: Goya, Stephanie. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; ArgentinaFil: Konig, Guido Alberto. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de InvestigaciĂłn BiotecnologĂa; ArgentinaFil: Konig, Guido Alberto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Lucero, Horacio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Nabaes Jodar, Mercedes. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Nabaes Jodar, Mercedes. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; ArgentinaFil: Pianciola, Luis. Ministerio de Salud. Laboratorio Central Ciudad de NeuquĂ©n; ArgentinaFil: Sfalcin, Javier A. CIBIC Laboratorio; ArgentinaFil: Acevedo, RaĂşl M. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Acevedo, RaĂşl M. Universidad Nacional del Nordeste-CONICET. Instituto de Botánica del Nordeste; ArgentinaFil: Bengoa Luoni, SofĂa Ailin. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de InvestigaciĂłn BiotecnologĂa; ArgentinaFil: Bengoa Luoni, Sofia Ailin. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de AgrobiotecnologĂa y BiologĂa Molecular; Argentina.Fil: Bolatti, Elisa M. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Bolatti, Elisa M. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa Molecular y Celular de Rosario. Grupo VirologĂa Humana; ArgentinaFil: BrusĂ©s, Bettina. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Cacciabue, Marco Polo Domingo. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de InvestigaciĂłn BiotecnologĂa; ArgentinaFil: Cacciabue, Marco Polo Domingo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de AgrobiotecnologĂa y BiologĂa Molecular; Argentina.Fil: Casal, Pablo E. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa Molecular y Celular de Rosario. Grupo VirologĂa Humana; ArgentinaFil: Cerri, Agustina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Cerri, Agustina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa Molecular y Celular de Rosario. Grupo VirologĂa Humana; ArgentinaFil: Chouhy, Diego. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Chouhy, Diego. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa Molecular y Celular de Rosario. Grupo VirologĂa Humana; ArgentinaFil: Dus Santos, Maria Jose. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de VirologĂa; ArgentinaFil: Dus Santos, Maria Jose. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de VirologĂa e Innovaciones TecnolĂłgicas; ArgentinaFil: Dus Santos, Maria Jose. Universidad Nacional de Hurlingham. Laboratorio de DiagnĂłstico-UNIDAD COVID; ArgentinaFil: Eberhardt, MarĂa Florencia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Eberhardt, MarĂa Florencia. Instituto Nacional de TecnologĂa Agropecuaria (INTA). EstaciĂłn Experimental Agropecuaria Rafaela. Instituto de InvestigaciĂłn de la Cadena Láctea; ArgentinaFil: Fernandez, Ailen. Ministerio de Salud. Laboratorio Central Ciudad de NeuquĂ©n; ArgentinaFil: Fernandez, Paula Del Carmen. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de InvestigaciĂłn BiotecnologĂa; ArgentinaFil: Fernandez, Paula Del Carmen. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de AgrobiotecnologĂa y BiologĂa Molecular; Argentina.Fil: Fernández Do Porto, DarĂo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Fernández Do Porto, DarĂo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo; ArgentinaFil: Formichelli, Laura. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Gismondi, MarĂa InĂ©s. CIBIC Laboratorio; ArgentinaFil: Gismondi, MarĂa InĂ©s. Universidad Nacional de Luján. Departamento de Ciencias Básicas; ArgentinaFil: Irazoqui, Jose Matias. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Irazoqui, Jose Matias. Instituto Nacional de TecnologĂa Agropecuaria (INTA). EstaciĂłn Experimental Agropecuaria Rafaela. Instituto de InvestigaciĂłn de la Cadena Láctea; ArgentinaFil: Lorenzini Campos, Melina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Lorenzini Campos, Melina. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Lusso, Silvina. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; ArgentinaFil: Marquez, Nathalie. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de PatologĂa Vegetal; ArgentinaFil: Muñoz Hidalgo, Marianne Graziel. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de InvestigaciĂłn BiotecnologĂa. Unidad de GenĂłmica; ArgentinaFil: Muñoz Hidalgo, Marianne Graziel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de AgrobiotecnologĂa y BiologĂa Molecular; Argentina.Fil: Mussin, Javier. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Mussin, Javier. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Natale, MĂłnica. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; ArgentinaFil: Oria, Griselda. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Pisano, MarĂa BelĂ©n. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Pisano, MarĂa BelĂ©n. Universidad Nacional de CĂłrdoba(UNC). Facultad de Ciencias MĂ©dicas. Instituto de VirologĂa “Dr. J. M. Vanella”; ArgentinaFil: Posner, Victoria. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Posner, Victoria. Universidad Nacional de Rosario, Rosario. Facultad de Ciencias BioquĂmicas y FarmacĂ©uticas. Laboratorio Mixto de BiotecnologĂa Acuática; ArgentinaFil: Puebla, Andrea Fabiana. Instituto Nacional de TecnologĂa Agropecuaria (INTA). Instituto de InvestigaciĂłn BiotecnologĂa. Unidad de GenĂłmica; ArgentinaFil: Puebla, Andrea Fabiana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de AgrobiotecnologĂa y BiologĂa Molecular; Argentina.Fil: Viegas, Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Viegas, Mariana. Hospital de Niños Dr. Ricardo GutiĂ©rrez. Laboratorio de VirologĂa; Argentin
Current ophthalmology practice patterns for syphilitic uveitis
Abstract
BACKGROUND:
Syphilitic uveitis is re-emerging alongside the systemic infection. In July 2017, an international group of uveitis-specialised ophthalmologists formed the International Ocular Syphilis Study Group to define current practice patterns.
METHODS:
103 Study Group members based in 35 countries completed a 25-item questionnaire focused on case load, clinical presentations, use and interpretation of investigations, treatment and clinical indicators of poor prognosis.
RESULTS:
Members managed a mean of 6.1 patients with syphilitic uveitis in clinics that averaged 707 annual cases of uveitis (0.9%); 53.2% reported increasing numbers over the past decade. Patients presented to more members (40.2%) during secondary syphilis. Uveitis was usually posterior (60.8%) or pan (22.5%); complications included optic neuropathy, macular oedema and posterior synechiae. All members diagnosed syphilitic uveitis using serological tests (simultaneous or sequential testing algorithms), and 97.0% routinely checked for HIV co-infection. Cerebrospinal fluid (CSF) analysis was ordered by 90.2% of members, and 92.7% took uveitis plus Venereal Disease Research Laboratory test (VDRL) or fluorescent treponemal antibody absorption test (FTA-ABS) to indicate neurosyphilis. Patients were commonly co-managed with infectious disease physicians, and treated with penicillin for at least 10-14 days, plus corticosteroid. Features predicting poor outcome included optic neuropathy (86.3%) and initial misdiagnosis (63.7%). Reasons for delayed diagnosis were often practitioner-related. 82.5% of members tested every patient they managed with uveitis for syphilis.
CONCLUSION:
This comprehensive report by an international group of uveitis-specialised ophthalmologists provides a current approach for the management of syphilitic uveitis