Transcutaneous disappearance curves of a cat using three different dosages of fluorescein-isothiocyanate-labelled sinistrin (A: 10 mg/kg, B: 30 mg/kg, C: 50 mg/kg).

<p>The x-axis represents time, the y-axis represents the relative transcutaneous fluorescence. The dose of 30 mg/kg (B) results in an adequate peak concentration.</p

Results of serum sinistrin and transcutaneous fluorescein-isothiocyanate-labelled sinistrin clearance in all animals studied.

<p>(<i>FITC-S = fluorescein-isothiocyanate-labelled sinistrin, k = transfer rate between compartments, Vss = Volume of distribution under steady state conditions</i>).</p><p>Results of serum sinistrin and transcutaneous fluorescein-isothiocyanate-labelled sinistrin clearance in all animals studied.</p

Transcutaneous disappearance curves of fluorescein-isothiocyanate-labelled sinistrin in three dogs (A–C) and three cats (D–F) using a dose of 30 mg/kg.

<p>Transcutaneous disappearance curves of fluorescein-isothiocyanate-labelled sinistrin in three dogs (A–C) and three cats (D–F) using a dose of 30 mg/kg.</p

Transcutaneous disappearance curves of fluorescein-isothiocyanate-labelled sinistrin in a dog with the device placed on the four different locations (A – hindlimb, B – forelimb, C – ventral abdomen, D – lateral thorax).

<p>The x-axis represents time, the y-axis represents the relative transcutaneous fluorescence. Note that there are minimal artifacts in curve D.</p

Plasma inulin data in all animals studied.

<p>Plasma inulin data in all animals studied.</p

The miniaturized device is placed on a clipped area on the ventral abdomen of a beagle dog and attached using a sticky patch.

<p>The miniaturized device is placed on a clipped area on the ventral abdomen of a beagle dog and attached using a sticky patch.</p