Backdoors in Pseudorandom Number Generators:Possibility and Impossibility Results

Inspired by the Dual EC DBRG incident, Dodis et al. (Eurocrypt 2015) initiated the formal study of backdoored PRGs, showing that backdoored PRGs are equivalent to public key encryption schemes, giving constructions for backdoored PRGs (BPRGs), and showing how BPRGs can be ``immunised\u27\u27 by careful post-processing of their outputs. In this paper, we continue the foundational line of work initiated by Dodis et al., providing both positive and negative results. We first revisit the backdoored PRG setting of Dodis et al., showing that PRGs can be more strongly backdoored than was previously envisaged. Specifically, we give efficient constructions of BPRGs for which, given a single generator output, Big Brother can recover the initial state and, therefore, all outputs of the BPRG. Moreover, our constructions are forward-secure in the traditional sense for a PRG, resolving an open question of Dodis et al. in the negative. We then turn to the question of the effectiveness of backdoors in robust PRNGs with input (c.f. Dodis et al., ACM-CCS 2013): generators in which the state can be regularly refreshed using an entropy source, and in which, provided sufficient entropy has been made available since the last refresh, the outputs will appear pseudorandom. The presence of a refresh procedure might suggest that Big Brother could be defeated, since he would not be able to predict the values of the PRNG state backwards or forwards through the high-entropy refreshes. Unfortunately, we show that this intuition is not correct: we are also able to construct robust PRNGs with input that are backdoored in a backwards sense. Namely, given a single output, Big Brother is able to rewind through a number of refresh operations to earlier ``phases\u27\u27, and recover all the generator\u27s outputs in those earlier phases. Finally, and ending on a positive note, we give an impossibility result: we provide a bound on the number of previous phases that Big Brother can compromise as a function of the state-size of the generator: smaller states provide more limited backdooring opportunities for Big Brother

Mind the Gap: Curating Digital Commons Metadata for SHARE

The goal of the SHARE initiative, a partnership between the Association of Research Libraries (ARL) and the Center for Open Science (COS), is to build a “free, open, data set about research and scholarly activities across their life cycle.” To date, more than 150 repositories and publishers have made metadata available to SHARE for harvesting, and the aggregated data set is available for searching. Many metadata providers are institutional repositories using the bepress Digital Commons platform whose metadata is harvested through the OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting) protocol for repository interoperability. As part of the 2016-2017 SHARE Curation Associates program, a group within the cohort began a unique project in July 2016 to review their institutional metadata and the specific elements that are being harvested by SHARE. The project arose out of the overall goal to enhance their own metadata within SHARE. And within this cohort of associates, a number of associates are at institutions utilizing the Digital Commons platform. At ACRL 2017, we presented a poster on our findings at that time. In this talk, I will share the curation activity to date and update the activity of these 4 librarians from different institutions. We will look at the result of harvesting and some thoughts on how we can continue improve our metadata for interoperability. We would also appreciate feedback on this endeavour and seek input from our colleagues

Free and Open-Source Automated Open Access Preprint Harvesting

Universities are attempting to ensure that all of their research is publicly accessible because of funding mandates. Many universities have established campus open access (OA) repositories but are struggling with how to upload millions of manuscripts under numerous license agreements while also linking metadata to make them discoverable. To do this manually requires around 15 minutes per manuscript from an experienced librarian. The time and cost to do this campus-wide is prohibitive. To radically reduce the time and costs of this process and to harvest all past work, this article reports on the development and testing of a free and open source (FOSS) JavaScript-based application, aperta-accessum, which does the following: 1) harvests names and emails from a department’s faculty webpage; 2) identifies scholars’ Open Researcher and Contributor IDentifiers (ORCID iDs); 3) obtains digital object identifiers (DOIs) of publications for each scholar; 4) checks for existing copies in an institution’s OA repository; 5) identifies the legal opportunities to provide OA versions of all of the articles not already in the OA repository; 6) sends authors emails requesting a simple upload of author manuscripts; and 7) adds link-harvested metadata from DOIs with uploaded preprints into a bepress repository; the code can be modified for additional repositories. The results of this study show that, in the administrative time needed to make a single document OA manually, aperta-accessum can process approximately five entire departments worth of peer-reviewed articles. Following best practices discussed, it is clear that this opensource OA harvester enables institutional library’s stewardship of OA knowledge on a mass scale for radically reduced costs

Decision‐making in nursing research and practice: application of the cognitive continuum theory: a meta‐aggregative systematic review.

To explore how the Cognitive Continuum Theory has been used in qualitative nursing research and to what extent it has been integrated in the research process using the Qualitative Network for Theory Use and Methodology (QUANTUM). Theory, research and nursing are intrinsically linked, as are decision-making and nursing practice. With increasing pressure on nurses to improve patient outcomes, systematic knowledge regarding decision-making is critical and urgent. A meta-aggregative systematic review. Databases: CINAHL, Medline, PsycINFO, Embase and PubMed were searched from inception until May 2022 for peer-reviewed research published in English. Seven studies were included and assessed for methodological quality using the Joanna Briggs Institute checklist for qualitative research. A meta-aggregative synthesis was conducted using Joanna Briggs methodology. The QUANTUM typology was used to evaluate the visibility of the Cognitive Continuum Theory in the research process. The review identified five synthesised findings, namely: 1. the decision-making capacity of the individual nurse, 2. nurses' level of experience, 3. availability of decision support tools, 4. the availability of resources and 5. access to senior staff and peers. Only two of seven studies rigorously applied the theory. The included studies were mainly descriptive-exploratory in nature. The transferability of the Cognitive Continuum Theory was demonstrated; however, evolution or critique was absent. A gap in the provision of a patient-centric approach to decision-making was identified. Education, support and research is needed to assist decision-making. A new Person-Centred Nursing Model of the Cognitive Continuum Theory has been proposed to guide future research in clinical decision-making. Relevance to Clinical Practice: Nurses make numerous decisions every day that directly impact patient care, therefore development and testing of new theories, modification and revision of older theories to reflect advances in knowledge and technology in contemporary health care are essential

Open By Default? Concept-Mapping Our Way to Open Access Consensus

By its nature design thinking combines creative and critical thinking that is imperative to organizing ideas and improving situations. Design thinking allows libraries to take an iterative approach to exploring a complex problem-space, and generate consensus around a potential solution, all while providing artifacts and documentation of the process. In libraries, design thinking is most commonly employed in the design of spaces or services. However, inspired by Open Access Week, we engaged these strategies to collaboratively deconstruct Western Libraries’ current policies related to open access. We invited staff and librarians from Western Libraries and our affiliates to explore how we define open access, and why and how our libraries support it. Using a collaborative concept-mapping approach, all members of the group individually answered each question, and then collaboratively mapped the answers. These concept maps have informed Western Libraries’ new statement on open access practices and policies. Our poster outlines this process and displays the resulting concept maps, offering a framework for integrating design-thinking into the process of policy development

Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review

To find out whether food-producing animals (FPAs) are a source of extraintestinal expanded-spectrum cephalosporin-resistant Escherichia coli (ESCR-EC) infections in humans, Medline, Embase, and the Cochrane Database of Systematic Reviews were systematically reviewed. Thirty-four original, peer-reviewed publications were identified for inclusion. Six molecular epidemiology studies supported the transfer of resistance via whole bacterium transmission (WBT), which was best characterized among poultry in the Netherlands. Thirteen molecular epidemiology studies supported transmission of resistance via mobile genetic elements, which demonstrated greater diversity of geography and host FPA. Seventeen molecular epidemiology studies did not support WBT and two did not support mobile genetic element-mediated transmission. Four observational epidemiology studies were consistent with zoonotic transmission. Overall, there is evidence that a proportion of human extraintestinal ESCR-EC infections originate from FPAs. Poultry, in particular, is probably a source, but the quantitative and geographical extent of the problem is unclear and requires further investigation

How long do you think? Unresponsive dying patients in a specialist palliative care service: a consecutive cohort study.

Predicting length of time to death once the person is unresponsive and deemed to be dying remains uncertain. Knowing approximately how many hours or days dying loved ones have left is crucial for families and clinicians to guide decision-making and plan end-of-life care. To determine the length of time between becoming unresponsive and death, and whether age, gender, diagnosis or location-of-care predicted length of time to death. Retrospective cohort study. Time from allocation of an Australia-modified Karnofsky Performance Status (AKPS) 10 to death was analysed using descriptive narrative. Interval-censored survival analysis was used to determine the duration of patient's final phase of life, taking into account variation across age, gender, diagnosis and location of death. A total of 786 patients, 18 years of age or over, who received specialist palliative care: as hospice in-patients, in the community and in aged care homes, between January 1st and October 31st, 2022. The time to death after a change to AKPS 10 is 2 days (n = 382; mean = 2.1; median = 1). Having adjusted for age, cancer, gender, the standard deviation of AKPS for the 7-day period prior to death, the likelihood of death within 2 days is 47%, with 84% of patients dying within 4 days. This study provides valuable new knowledge to support clinicians' confidence when responding to the 'how long' question and can inform decision-making at end-of-life. Further research using the AKPS could provide greater certainty for answering 'how long' questions across the illness trajectory

Proteolytic processing of TGFα redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine

AbstractWild-type transforming growth factor α (TGFα) expression in lactotrope cells in the pituitary gland led to lactotrope-specific pituitary hyperplasia and adenomata. To indicate whether the EGF receptor is involved in this TGFα-mediated phenotype, we bred TGFα mice with mice expressing the cytoplasmic truncated-EGF receptor (EGFR-tr), which is dominant-negative in other models. These bitransgenic mice developed pituitary pathology despite expression of the dominant-negative receptor. To further characterize this observation, we generated two lineages of transgenic mice that overexpress mutant forms of TGFα: a processed soluble form (s TGFα) and a cytoplasmic-deleted form (TGFαΔC). While sTGFα expression in lactotrope cells failed to induce autocrine lactotrope hyperplasia, the pituitary became very enlarged due to proliferation of neighboring interstitial cells. In contrast, the TGFαΔC mice did not develop a phenotype, although the mRNA and protein were present in the pituitary and this form of TGFα was confirmed to be biologically active and targeted properly to the plasma membrane of cultured CHO cells. The results suggest that the cytoplasmic domain of TGFα is required for autocrine parenchymal tumor formation in the pituitary gland. This signal cannot be inhibited by the EGFR-tr. Conversely, the released form of TGFα appears to have primarily paracrine activity

Promoting influenza vaccine for children

This autumn influenza vaccine will again be offered to all 2- and 3-year-olds in general practice. In addition, all children in clinical risk groups aged 6 months and above should be offered the vaccine. Children in primary school years from reception class to year 4 will also be offered the vaccine as part of the on-going extension of influenza vaccination to healthy children. Since the start of the paediatric programme, transmission of influenza has reduced across all age groups in those parts of the country vaccinating all children of primary school age. Children under 5 years of age have the highest rate of hospital admissions for influenza. However, many parents do not think that influenza is a serious illness and it is the vaccine they are most likely to decline. Health professionals are the most trusted source of advice and information about vaccination, so staff in general practice have a crucial role to play in recommending this vaccine to parents. Health professionals are the most trusted source of advice and information about vaccination, so practice nurses have a crucial role to play in recommending the influenza vaccine to parents and increasing uptake </jats:p