Variability in N Acetyl Aspartate/Creatine ratio measurements.

<p>Box and whisker plot for N Acetyl Aspartate/Creatine ratio for a selection of the regions of interest (ROI), including right (R) and left (L) corticospinal (CST), anterior thalamic radiation (ATR), thalamus, putamen, frontal lobe, hippocampus and temporal lobe. The spread of data within each ROI reflects inter subject variation, while the difference between runs 1 – 2 and 3 – 4 reflects within session reproducibility, and the change from first to second sessions reflects between session reproducibility. The central lines in each box denote median values, the lower and upper boundaries the 25th and 75th centile, the error bars the 10th and 90th centile, and the closed circles outlying data points.</p

Variability in N Acetyl Aspartate concentration.

<p>Box and whisker plot for N Acetyl Aspartate for a selection of the regions of interest (ROI), including right (R) and left (L) corticospinal (CST), anterior thalamic radiation (ATR), thalamus, putamen, frontal lobe, hippocampus and temporal lobe. The spread of data within each ROI reflects inter subject variation, while the difference between runs 1 – 2 and 3 – 4 reflects within session reproducibility, and the change from first to second sessions reflects between session reproducibility. The central lines in each box denote median values, the lower and upper boundaries the 25th and 75th centile, the error bars the 10th and 90th centile, and the closed circles outlying data points.</p

Intersubject variability of metabolite ratios for whole brain proton spectroscopy.

<p>Intersubject variability for Choline/Creatine, N-Acetyl aspartate (NAA)/Choline and N-Acetyl aspartate/Creatine. Data displayed were obtained in 32 subjects and show mean, standard deviation (SD) and percentage coefficient of variation (CoV%) for each region of interest (ROI).</p><p>Intersubject variability of metabolite ratios for whole brain proton spectroscopy.</p

Within session and between session intraclass correlation coefficient for metabolites.

<p>Data displayed are mean (95% Confidence interval) intraclass correlation coefficient for metabolite ratios (Choline (Cho)/Creatine (Cr), N Acetyl Aspartate (NAA)/Cho, NAA/Cr) and metabolites (NAA, Cho and Cr) for mixed cortical and deep grey, and white matter brain regions.</p><p>Within session and between session intraclass correlation coefficient for metabolites.</p

Analysis of variance table for metabolite ratios.

<p>Data were obtained from 32 volunteers using the region of interest (ROI) template for metabolite ratios. (Choline – Cho, Creatine – Cr, N acetyl aspartate – NAA and DF – Degrees of freedom).</p><p>Analysis of variance table for metabolite ratios.</p

Analysis of variance table for metabolite ratios.

<p>Data were obtained from 32 volunteers using the region of interest (ROI) template for and metabolite concentrations. (Choline – Cho, Creatine – Cr, N acetyl aspartate – NAA and DF – Degrees of freedom).</p><p>Analysis of variance table for metabolite ratios.</p

Intersubject variability of metabolite concentrations for whole brain proton spectroscopy.

<p>Intersubject variability for N-Acetyl aspartate (NAA), Choline (Cho) and Creatine (Cr). Data displayed were obtained in 32 subjects and show mean, standard deviation (SD) and percentage coefficient of variation (CoV%) for each region of interest (ROI).</p><p>Intersubject variability of metabolite concentrations for whole brain proton spectroscopy.</p

Within session and between session variability of metabolites for whole brain proton spectroscopy.

<p><i>Individual region of interest measurements for within session reproducibility obtained in the first and second imaging sessions in 17 and 16 subjects respectively, and the between session reproducibility for those 22 subjects who underwent imaging at both sessions. Data displayed are standard deviation for metabolite ratios (Choline (Cho)/Creatine (Cr), N-Acetyl aspartate (NAA)/Choline and NAA/Cr.</i></p><p>Within session and between session variability of metabolites for whole brain proton spectroscopy.</p

Metabolite parametric maps.

<p>T1 weighted magnetic resonance image in MNI152 space (2mm resolution) with a representative spectra from the right thalamus and N-acetyl aspartate (NAA), Creatine (Cr) and Choline (Cho) signal-intensity normalised metabolite concentration parametric maps. PPM (parts per million).</p

Region of interest template.

<p>T1 weighted magnetic resonance image in MNI152 space (2mm resolution) showing frontal lobe left (L Frontal), frontal lobe right (R Frontal), anterior corpus callosum (ACC), thalamus left (L Thalamus), thalamus right (R Thalamus), occipital left (L Occipital), occipital right (R Occipital), putamen left (L Putamen) and putamen right (R Putamen). Additional regions not shown include body corpus callosum, posterior corpus callosum, dorsal mid brain, ventral mid brain and bilateral regions covering the corticospinal tract, anterior thalamic radiation, inferior longitudinal fasciculus, superior longitudinal fasciculus, pallidum, hippocampus, parietal lobe, temporal lobe, cerebral peduncle and pons.</p