Exemplary parcellation of hippocampus: red = hippocampus, yellow = cortex, blue = cerebro-spinal fluid.

<p>Exemplary parcellation of hippocampus: red = hippocampus, yellow = cortex, blue = cerebro-spinal fluid.</p

Hippocampal volumes (A) and concentration of metabolities: (B) N-acetylaspartate+N-acetylaspartylglutamate (tNAA), (C) glutamate (Glu) and (D) creatine+phosphocreatine (tCr).

<p>White and black graphs represent control (CONs) and high-fat high carbohydrate diet-treated (OBRs) animals, respectively. The graphs show median values with 25–75% variability range and maximal and minimal values. Decimal indexes indicate statistical significance of intergroup differences (Mann–Whitney U-test).</p

Exemplary proton spectrum with fitted baseline.

<p>Exemplary proton spectrum with fitted baseline.</p

Daily energy intake (A), changes in body weight during the experiment (B), changes in glucose blood levels (C), and changes in blood levels of ketone bodies (D) in controls and HFD-fed rats.

<p>*<i>P</i><0.05, ***<i>P</i><0.01. The “spikes” in levels of ketone bodies were caused by short-lived increases in concentrations of ketone bodies in single animals.</p

Volume of interest placement.

<p>Volume of interest placement.</p

Exemplary parameters of the animal behavior during five-day maze tests performed/repeated at the 9^th month of age.

<p>(A) the total time (seconds) spent in the maze before the reward was reached by the animal on day 1^st, 2^nd, 3^rd, 4^th, and 5^th, (B) the time of walking (seconds) to reach the reward, (C) the time of immobility (seconds), (D) the total walking distance (meters). Abbreviations: White and black graphs characterize control and high-fat high carbohydrate diet-treated animals, respectively. The graphs show median values (squares), 25–75% variability ranges (vertically arranged rectangles), and maximal and minimal values (whiskers). Decimal indexes located below the graphs indicate statistical significance of intergroup differences at a given maze test (Mann–Whitney U-test).</p