2 research outputs found
Cu-Catalyzed Mild C(sp<sup>2</sup>)–H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes
A formal
Cu-catalyzed CÂ(sp<sup>2</sup>)–H hydroxylation
assisted by benzoic acids is described. The procedure is characterized
by its mild reaction conditions and wide substrate scope utilizing
simple and cheap Cu catalysts, thus becoming a user-friendly and operationally
simple protocol for CÂ(sp<sup>2</sup>)–H hydroxylation
Direct Asymmetric Ruthenium-Catalyzed Reductive Amination of Alkyl–Aryl Ketones with Ammonia and Hydrogen
The asymmetric ruthenium-catalyzed
reductive amination employing
ammonia and hydrogen to primary amines is described. Here we demonstrate
the capability of our catalyst to perform a chemo- and enantioselective
process while using simple ammonia gas as a reagent, one of the most
attractive and industrially relevant nitrogen sources. The presence
of a catalytic amount of ammonium iodide was essential for obtaining
good yields and enantioselectivities. The mechanism of this reaction
was investigated by DFT and we found a viable pathway that also explains
the trend and magnitude of enantioselectivity through the halide series
in good agreement with the experimental data. The in-depth investigation
of substrate conformers during the reaction turned out to be crucial
in obtaining an accurate prediction of the enantioselectivity. Furthermore,
we report the crystallographic data of the chiral [RuÂ(I)ÂHÂ(CO)Â((<i>S</i>,<i>S</i>)-<i>f</i>-binaphane)Â(PPh<sub>3</sub>)] complex, which we identified as the most efficient catalyst
in our investigation