159 research outputs found
Recurrent Neurotropic Chloroma: Report of a Case and Review of the Literature
We are reporting a case of a young woman with acute myelogenous leukemia status postallogeneic transplantation who developed multiply recurrent chloromas occurring along peripheral nerves in the absence of bone marrow relapse, all treated with radiation therapy. The patient is currently free of disease nearly four years after her first posttransplant chloroma. The case presented is unique for its isolated peripheral nervous system involvement, rare posttransplant occurrence, and indolent course without marrow relapse despite multiple extramedullary recurrences
Proton therapy for adults with mediastinal lymphomas: The international lymphoma radiation oncology group guidelines
Among adult lymphoma survivors, radiation treatment techniques that increase the excess radiation dose to organs at risk (OARs) put patients at risk for increased side effects, especially late toxicities. Minimizing radiation to OARs in adults patients with Hodgkin and non-Hodgkin lymphomas involving the mediastinum is the deciding factor for the choice of treatment modality. Proton therapy may help to reduce the radiation dose to the OARs and reduce toxicities, especially the risks for cardiac morbidity and second cancers. Becauseproton therapymay have some disadvantages, identifying the patients and the circumstances that may benefit the most from proton therapy is important. We present modern guidelines to identify adult lymphoma patients who may derive the greatest benefit from proton therapy, along with an analysis of the advantages and disadvantages of proton treatment. (Blood. 2018;132(16):1635-1646)
Intramolecular Structural Heterogeneity altered by Long-range Contacts in an Intrinsically Disordered Protein
Short-range interactions and long-range contacts drive the 3D folding of
structured proteins. The proteins' structure has a direct impact on their
biological function. However, nearly 40% of the eukaryotes proteome is composed
of intrinsically disordered proteins (IDPs) and protein regions that fluctuate
between ensembles of numerous conformations. Therefore, to understand their
biological function, it is critical to depict how the structural ensemble
statistics correlate to the IDPs' amino acid sequence. Here, using small-angle
x-ray scattering (SAXS) and time-resolved F\"orster resonance energy transfer
(trFRET), we study the intra-molecular structural heterogeneity of the
neurofilament low intrinsically disordered tail domain (NFLt). Using
theoretical results of polymer physics, we find that the Flory scaling exponent
of NFLt sub-segments correlates linearly with their net charge, ranging from
statistics of ideal to self-avoiding chains. Surprisingly, measuring the same
segments in the context of the whole NFLt protein, we find that regardless of
the peptide sequence, the segments' structural statistics are more expanded
than when measured independently. Our findings show that while polymer physics
can, to some level, relate the IDP's sequence to its ensemble conformations,
long-range contacts between distant amino acids play a crucial role in
determining intra-molecular structures. This emphasizes the necessity of
advanced polymer theories to fully describe IDPs ensembles with the hope it
will allow us to model their biological function
âDie Stadt selbst ist unangenehmâ
Von  Leon Lampe, Leonie Koren, Anne-Dorothea Schmiesing Der alte Goethe mochte die Stadt nicht. Die Natur aber schon, wie das dieses Zitat zeigt: âDie Stadt selbst ist unangenehm, dagegen rings umher eine unaussprechliche SchĂśnheit der Natur.â Hätte Goethe die heutige Stadt gemocht? Hätte er unser Verständnis von Natur in der Stadt fĂźr gut befunden? Natur in der Stadt. Von Anfang an nie eingeplant, schaffte die Natur durch Einwanderung von Tieren und Pflanzen in die Stadt, in den Lebensraum d..
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