Design and implementation of sparse aperture imaging systems

In order to better understand the technological difficulties involved in designing and building a sparse aperture array, the challenge of building a white light Golay-3 telescope was undertaken. The MIT Adaptive Reconnaissance Golay-3 Optical Satellite (ARGOS) project exploits wide-angle Fizeau interferometer technology with an emphasis on modularity in the optics and spacecraft subsystems. Unique design procedures encompassing the nature of coherent wavefront sensing, control and combining as well as various system engineering aspects to achieve cost effectiveness, are developed. To demonstrate a complete spacecraft in a 1-g environment, the ARGOS system is mounted on a frictionless air-bearing, and has the ability to track fast orbiting satellites like the ISS or the planets. Wavefront sensing techniques are explored to mitigate initial misalignment and to feed back real-time aberrations into the optical control loop. This paper presents the results and the lessons learned from the conceive, design and implementation phases of ARGOS. A preliminary assess-ment shows that the beam combining problem is the most challenging aspect of sparse optical arrays. The need for optical control is paramount due to tight beam combining tolerances. The wavefront sensing/control requirements appear to be a major technology and cost driver

ARGOS testbed: study of multidisciplinary challenges of future spaceborne interferometric arrays

Future spaceborne interferometric arrays must meet stringent optical performance and tolerance requirements while exhibiting modularity and acceptable manufacture and integration cost levels. The Massachusetts Institute of Technology (MIT) Adaptive Reconnaissance Golay-3 Optical Satellite (ARGOS) is a wide-angle Fizeau interferometer spacecraft testbed designed to address these research challenges. Designing a space-based stellar interferometer, which requires tight tolerances on pointing and alignment for its apertures, presents unique multidisciplinary challenges in the areas of structural dynamics, controls, and multiaperture phasing active optics. In meeting these challenges, emphasis is placed on modularity in spacecraft subsystems and optics as a means of enabling expandability and upgradeability. A rigorous theory of beam-combining errors for sparse optical arrays is derived and flown down to the design of various subsystems. A detailed elaboration on the optics system and control system is presented based on the performance requirements and beam-combining error tolerances. The space environment is simulated by floating ARGOS on a frictionless air-bearing that enables it to track both fast and slow moving targets

IMMUNOCAT—A Data Management System for Epitope Mapping Studies

To enable rationale vaccine design, studies of molecular and cellular mechanisms of immune recognition need to be linked with clinical studies in humans. A major challenge in conducting such translational research studies lies in the management and integration of large amounts and various types of data collected from multiple sources. For this purpose, we have established “IMMUNOCAT”, an interactive data management system for the epitope discovery research projects conducted by our group. The system provides functions to store, query, and analyze clinical and experimental data, enabling efficient, systematic, and integrative data management. We demonstrate how IMMUNOCAT is utilized in a large-scale research contract that aims to identify epitopes in common allergens recognized by T cells from human donors, in order to facilitate the rational design of allergy vaccines. At clinical sites, demographic information and disease history of each enrolled donor are captured, followed by results of an allergen skin test and blood draw. At the laboratory site, T cells derived from blood samples are tested for reactivity against a panel of peptides derived from common human allergens. IMMUNOCAT stores results from these T cell assays along with MHC:peptide binding data, results from RAST tests for antibody titers in donor serum, and the respective donor HLA typing results. Through this system, we are able to perform queries and integrated analyses of the various types of data. This provides a case study for the use of bioinformatics and information management techniques to track and analyze data produced in a translational research study aimed at epitope identification

ARGOS testbed: study of multidisciplinary challenges of future spaceborne interferometric arrays

Future spaceborne interferometric arrays must meet stringent optical performance and tolerance requirements while exhibiting modularity and acceptable manufacture and integration cost levels. The Massachusetts Institute of Technology (MIT) Adaptive Reconnaissance Golay-3 Optical Satellite (ARGOS) is a wide-angle Fizeau interferometer spacecraft testbed designed to address these research challenges. Designing a space-based stellar interferometer, which requires tight tolerances on pointing and alignment for its apertures, presents unique multidisciplinary challenges in the areas of structural dynamics, controls, and multiaperture phasing active optics. In meeting these challenges, emphasis is placed on modularity in spacecraft subsystems and optics as a means of enabling expandability and upgradeability. A rigorous theory of beam-combining errors for sparse optical arrays is derived and flown down to the design of various subsystems. A detailed elaboration on the optics system and control system is presented based on the performance requirements and beam-combining error tolerances. The space environment is simulated by floating ARGOS on a frictionless air-bearing that enables it to track both fast and slow moving targets

Design and implementation of sparse aperture imaging systems

In order to better understand the technological difficulties involved in designing and building a sparse aperture array, the challenge of building a white light Golay-3 telescope was undertaken. The MIT Adaptive Reconnaissance Golay-3 Optical Satellite (ARGOS) project exploits wide-angle Fizeau interferometer technology with an emphasis on modularity in the optics and spacecraft subsystems. Unique design procedures encompassing the nature of coherent wavefront sensing, control and combining as well as various system engineering aspects to achieve cost effectiveness, are developed. To demonstrate a complete spacecraft in a 1-g environment, the ARGOS system is mounted on a frictionless air-bearing, and has the ability to track fast orbiting satellites like the ISS or the planets. Wavefront sensing techniques are explored to mitigate initial misalignment and to feed back real-time aberrations into the optical control loop. This paper presents the results and the lessons learned from the conceive, design and implementation phases of ARGOS. A preliminary assess-ment shows that the beam combining problem is the most challenging aspect of sparse optical arrays. The need for optical control is paramount due to tight beam combining tolerances. The wavefront sensing/control requirements appear to be a major technology and cost driver

ARGOS testbed: study of multidisciplinary challenges of future spaceborne interferometric arrays

Abstract. Future spaceborne interferometric arrays must meet stringent optical performance and tolerance requirements while exhibiting modularity and acceptable manufacture and integration cost levels. The Massachusetts Institute of Technology (MIT) Adaptive Reconnaissance Golay-3 Optical Satellite (ARGOS) is a wide-angle Fizeau interferometer spacecraft testbed designed to address these research challenges. Designing a space-based stellar interferometer, which requires tight tolerances on pointing and alignment for its apertures, presents unique multidisciplinary challenges in the areas of structural dynamics, controls, and multiaperture phasing active optics. In meeting these challenges, emphasis is placed on modularity in spacecraft subsystems and optics as a means of enabling expandability and upgradeability. A rigorous theory of beam-combining errors for sparse optical arrays is derived and flown down to the design of various subsystems. A detailed elaboration on the optics system and control system is presented based on the performance requirements and beam-combining error tolerances. The space environment is simulated by floating ARGOS on a frictionless airbearing that enables it to track both fast and slow moving targets

TiArA: A Virtual Appliance for the Analysis of Tiling Array Data

Genomic tiling arrays have been described in the scientific literature since 2003, yet there is a shortage of user-friendly applications available for their analysis.Tiling Array Analyzer (TiArA) is a software program that provides a user-friendly graphical interface for the background subtraction, normalization, and summarization of data acquired through the Affymetrix tiling array platform. The background signal is empirically measured using a group of nonspecific probes with varying levels of GC content and normalization is performed to enforce a common dynamic range.TiArA is implemented as a standalone program for Linux systems and is available as a cross-platform virtual machine that will run under most modern operating systems using virtualization software such as Sun VirtualBox or VMware. The software is available as a Debian package or a virtual appliance at http://purl.org/NET/tiara

Spinons and triplons in spatially anisotropic frustrated antiferromagnets

The search for elementary excitations with fractional quantum numbers is a central challenge in modern condensed matter physics. We explore the possibility in a realistic model for several materials, the spin-1/2 spatially anisotropic frustrated Heisenberg antiferromagnet in two dimensions. By restricting the Hilbert space to that expressed by exact eigenstates of the Heisenberg chain, we derive an effective Schr\"odinger equation valid in the weak interchain-coupling regime. The dynamical spin correlations from this approach agree quantitatively with inelastic neutron measurements on the triangular antiferromagnet Cs_2CuCl_4. The spectral features in such antiferromagnets can be attributed to two types of excitations: descendents of one-dimensional spinons of individual chains, and coherently propagating "triplon" bound states of spinon pairs. We argue that triplons are generic features of spatially anisotropic frustrated antiferromagnets, and arise because the bound spinon pair lowers its kinetic energy by propagating between chains.Comment: 16 pages, 6 figure

Superconducting Sr2RuO4 Thin Films without Out-of-Phase Boundaries by Higher-Order Ruddlesden-Popper Intergrowth

Ruddlesden-Popper (RP) phases (An+1B n O3n+1, n = 1, 2,···) have attracted intensive research with diverse functionalities for device applications. However, the realization of a high-quality RP-phase film is hindered by the formation of out-of-phase boundaries (OPBs) that occur at terrace edges, originating from lattice mismatch in the c-axis direction with the A'B'O3 (n = ∞) substrate. Here, using strontium ruthenate RP-phase Sr2RuO4 (n = 1) as a model system, an experimental approach for suppressing OPBs was developed. By tuning the growth parameters, the Sr3Ru2O7 (n = 2) phase was formed in a controlled manner near the film-substrate interface. This higher-order RP-phase then blocked the subsequent formation of OPBs, resulting in nearly defect-free Sr2RuO4 layer at the upper region of the film. Consequently, the Sr2RuO4 thin films exhibited superconductivity up to 1.15 K, which is the highest among Sr2RuO4 films grown by pulsed laser deposition. This work paves the way for synthesizing pristine RP-phase heterostructures and exploring their unique physical properties

Research Participants’ Preferences for Hypothetical Secondary Results from Genomic Research

Secondary or incidental results can be identified in genomic research that increasingly uses whole exome/genome sequencing. Understanding research participants’ preferences for secondary results and what influences these decisions is important for patient education, counseling, and consent, and for the development of policies regarding return of secondary results. Two hundred nineteen research participants enrolled in genomic studies were surveyed regarding hypothetical preferences for specific types of secondary results, and these preferences were correlated with demographic information and psychosocial data. The majority of research participants (73%) indicated a preference to learn about all results offered, with no clear pattern regarding which results were not desired by the remaining participants. Participants who reported greater interest in genetic privacy were less likely to indicate a preference to learn all results, as were individuals who self‐identified as Jewish. Although most research participants preferred to receive all secondary results offered, a significant subset preferred to exclude some results, suggesting that an all‐or‐none policy would not be ideal for all participants. The correlations between preferences to receive secondary results, religious identification, and privacy concerns demonstrate the need for culturally sensitive counseling and educational materials accessible to all education levels to allow participants to make the best choices for themselves