Decaying grid turbulence in a rotating stratified fluid

Rotating grid turbulence experiments have been carried out in a stably stratified fluid for relatively large Reynolds numbers (mesh Reynolds numbers up to 18000). Under the combined effects of rotation and stratification the flow degenerates into quasihorizontal motions. This regime is investigated using a scanning imaging velocimetry technique which provides time-resolved velocity fields in a volume. The most obvious effect of rotation is the inhibition of the kinetic energy decay, in agreement with the quasi-geostrophic model which predicts the absence of a direct energy cascade, as found in two-dimensional turbulence. In the regime of small Froude and Rossby numbers, the dynamics is found to be non-dissipative and associated with a symmetric and highly intermittent vertical vorticity field, that displays k(h)(-3) energy spectra. For higher Rossby numbers, fundamental differences with the quasi-geostrophic model are found. A significant decay of kinetic energy, which does not depend on the stratification, is observed. Moreover, in this regime, although both cyclones and anticyclones are initially produced, the intense vortices are only cyclones. For late times the flow consists of an assembly of coherent interacting Structures. Under the influence of both rotation and stratification, they take the form of lens-like eddies with aspect ratio proportional to f/N

Introduction to the Special Issue “20 years of the Pathways Model: understanding disordered gambling and other behavioural addictions”

The Pathways Model of problem gambling has become a highly influential framework in the field of gambling studies. This special issue commemorates 20 years since the publication of the original paper, highlighting the sustained impact of the Pathways Model across the broader and emergent field of behavioral addictions. As a framework, the Pathways Model set out two distinct objectives: first, to synthesize an array of risk factors and psychological processes that have been implicated in the etiology of gambling problems, and second, to characterize heterogeneity among people with gambling problems. As the articles included in this collection confirm, the three subtypes proposed by Blaszczynski & Nower continue to be an especially powerful stimulus for research

Controlling Internal Pore Sizes in Bicontinuous Polymeric Nanospheres

Complex polymeric nanospheres were formed in water from comb-like amphiphilic block copolymers. Their internal morphology was determined by three-dimensional cryo-electron tomographic analysis. Varying the polymer molecular weight (MW) and the hydrophilic block weight content allowed for fine control over the internal structure. Construction of a partial phase diagram allowed us to determine the criteria for the formation of bicontinuous polymer nanosphere (BPN), namely for copolymers with MW of up to 17?kDa and hydrophilic weight fractions of ?0.25; and varying the organic solvent to water ratio used in their preparation allowed for control over nanosphere diameters from 70 to 460?nm. Significantly, altering the block copolymer hydrophilic–hydrophobic balance enabled control of the internal pore diameter of the BPNs from 10 to 19?nm

A comparison of coincidental time series of the ocean surface height by satellite altimeter, mooring, and inverted echo sounder

Altimetric measurements of sea surface height at two locations in the western tropical Pacific Ocean are compared to estimates of the dynamic sea surface height computed from cotemporal surface-to-bottom temperature/salinity measurements on moorings and acoustic travel time measured by bottom-moored inverted echo sounders. The results show statistically high correlation between the in situ measurements at periods greater than 5 days and between the altimeter and in situ measurements at periods greater than 20 days. The rms difference between any two modes of observation is consistently between 2 and 3 cm. (Résumé d'auteur

A casino in my pocket: Gratifications associated with obsessive and harmonious passion for mobile gambling

Mobile gambling differs from land-based and traditional forms of gambling in that the opportunity to place bets and engage with casinos is constantly present and easily accessible. Instead of going to a physical bookmaker or casino, mobile gambling is done quickly and swiftly, anytime, anywhere, with a few taps on a mobile device. Previous studies reveal mobile gambling has managed to reach new audiences especially amongst younger people. Gambling harms can have severe adverse effects on individuals, families and society. However, for a subgroup of highly involved individuals, gambling can be considered a harmonious passion that permits frequent gambling without elevating individual’s risks of experience problem gambling manifestations. Combining the Uses and Gratifications (U&G) and Dualistic Model of Passion (DMP) frameworks, the present study aims to determine if and how the different gratifications sought from mobile gambling are susceptible to explaining non-problematic versus problematic patterns in highly involved gamblers. Data were collected over two waves from a global sample of mobile gamblers (N = 327). Results emphasize that the motivational underpinnings of mobile gambling (as measured by the U&G) differ in obsessive versus harmonious passion. Obsessive passion is associated with poor mood and problematic gambling. In contrast, harmonious passion for mobile gambling is associated with positive mood but is unrelated to problematic gambling. Based on these findings, and given that problematic gambling is an internationally relevant public health issue (the prevalence of problem gambling is estimated to range from 0.1% to 5.8% in different countries), we suggest interventions focusing on specific uses and gratifications associated with an obsessive passion for mobile gambling may be effective in reducing problematic usage patterns

Giant slip lengths of a simple fluid at vibrating solid interfaces

It has been shown recently [PRL 102, 254503 (2009)] that in the plane-plane configuration a mechanical resonator vibrating close to a rigid wall in a simple fluid can be overdamped to a frozen regime. Here, by solving analytically the Navier Stokes equations with partial slip boundary conditions at the solid fluid interface, we develop a theoretical approach justifying and extending these earlier findings. We show in particular that in the perfect slip regime the above mentioned results are, in the plane-plane configuration, very general and robust with respect to lever geometry considerations. We compare the results with those obtained previously for the sphere moving perpendicularly and close to a plane in a simple fluid and discuss in more details the differences concerning the dependence of the friction forces with the gap distance separating the moving object (i.e., plane or sphere) from the fixed plane. Finally, we show that the submicron fluidic effect reported in the reference above, and discussed further in the present work, can have dramatic implications in the design of nano-electromechanical systems (NEMS).Comment: submitted to PRE (see also PRL 102, 254503 (2009)

The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer.

A better understanding of the dynamics of molecular changes occurring during the early stages of oral tumorigenesis may help refine prevention and treatment strategies. We generated genome-wide expression profiles of microdissected normal mucosa, hyperplasia, dysplasia and tumors derived from the 4-NQO mouse model of oral tumorigenesis. Genes differentially expressed between tumor and normal mucosa defined the "tumor gene set" (TGS), including 4 non-overlapping gene subsets that characterize the dynamics of gene expression changes through different stages of disease progression. The majority of gene expression changes occurred early or progressively. The relevance of these mouse gene sets to human disease was tested in multiple datasets including the TCGA and the Genomics of Drug Sensitivity in Cancer project. The TGS was able to discriminate oral squamous cell carcinoma (OSCC) from normal oral mucosa in 3 independent datasets. The OSCC samples enriched in the mouse TGS displayed high frequency of CASP8 mutations, 11q13.3 amplifications and low frequency of PIK3CA mutations. Early changes observed in the 4-NQO model were associated with a trend toward a shorter oral cancer-free survival in patients with oral preneoplasia that was not seen in multivariate analysis. Progressive changes observed in the 4-NQO model were associated with an increased sensitivity to 4 different MEK inhibitors in a panel of 51 squamous cell carcinoma cell lines of the areodigestive tract. In conclusion, the dynamics of molecular changes in the 4-NQO model reveal that MEK inhibition may be relevant to prevention and treatment of a specific molecularly-defined subgroup of OSCC