457 research outputs found

    Dynamically Adjusting the Mining Capacity in Cryptocurrency with Binary Blockchain

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    Many cryptocurrencies rely on Blockchain for its operation. Blockchain serves as a public ledger where all the completed transactions can be looked up. To place transactions in the Blockchain, a mining operation must be performed. However, due to a limited mining capacity, the transaction confirmation time is increasing. To mitigate this problem many ideas have been proposed, but they all come with own challenges. We propose a novel parallel mining method that can adjust the mining capacity dynamically depending on the congestion level. It does not require an increase in the block size or a reduction of the block confirmation time. The proposed scheme can increase the number of parallel blockchains when the mining congestion is experienced, which is especially effective under DDoS attack situation. We describe how and when the Blockchain is split or merged, how to solve the imbalanced mining problem, and how to adjust the difficulty levels and rewards. We then show the simulation results comparing the performance of binary blockchain and the traditional single blockchain

    分子動力学シミュレーションを用いた凝縮系のシングルビーム2次元ラマン分光法

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    京都大学新制・課程博士博士(理学)甲第23030号理博第4707号新制||理||1675(附属図書館)京都大学大学院理学研究科化学専攻(主査)教授 谷村 吉隆, 教授 渡邊 一也, 教授 林 重彦学位規則第4条第1項該当Doctor of ScienceKyoto UniversityDGA

    Hadoop Performance Analysis Model with Deep Data Locality

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    Background: Hadoop has become the base framework on the big data system via the simple concept that moving computation is cheaper than moving data. Hadoop increases a data locality in the Hadoop Distributed File System (HDFS) to improve the performance of the system. The network traffic among nodes in the big data system is reduced by increasing a data-local on the machine. Traditional research increased the data-local on one of the MapReduce stages to increase the Hadoop performance. However, there is currently no mathematical performance model for the data locality on the Hadoop. Methods: This study made the Hadoop performance analysis model with data locality for analyzing the entire process of MapReduce. In this paper, the data locality concept on the map stage and shuffle stage was explained. Also, this research showed how to apply the Hadoop performance analysis model to increase the performance of the Hadoop system by making the deep data locality. Results: This research proved the deep data locality for increasing performance of Hadoop via three tests, such as, a simulation base test, a cloud test and a physical test. According to the test, the authors improved the Hadoop system by over 34% by using the deep data locality. Conclusions: The deep data locality improved the Hadoop performance by reducing the data movement in HDFS

    sUTM System API at UNLV: Small UAS Traffic Management System API

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    This file contains the set of APIs for small unmanned aircraft systems (UAS) Traffic Management (sUTM). The sUTM server hosts a web service that allows any software or device that can use the Internet to utilize the server’s sUAS traffic management (sUTM) functions through these application programming interfaces (API). This library was developed as part of the MS thesis by Monetta Shaw in Spring 2016, A web based solution for small unmanned aircraft systems (sUAS) traffic management . The summary of the library and its usage instructions are described in the thesis

    Comparison of total body irradiation-based or non-total body irradiation-based conditioning regimens for allogeneic stem cell transplantation in pediatric leukemia patients

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    Purpose : This study aims to compare the outcome of total body irradiation (TBI)- or non-TBI-containing conditioning regimens for leukemia in children. Methods : We retrospectively evaluated 77 children conditioned with TBI (n=40) or non-TBI (n=37) regimens, transplanted at Chonnam National University Hospital between January 1996 and December 2007. The type of transplantation, disease status at the time of transplant, conditioning regimen, engraftment kinetics, development of graft-versus-host disease (GVHD), complications, cause of deaths, overall survival (OS), and event-free survival (EFS) were compared between the 2 groups. Results : Among 34 patients with acute lymphoblastic leukemia (ALL), 28 (82.4%) were in the TBI group, while 72.7% (24/33) of patients with myeloid leukemia were in the non-TBI group. Although the 5-year EFS of the 2 groups was similar for all patients (62% vs 63%), the TBI group showed a better 5-year EFS than the non-TBI group when only ALL patients were analyzed (65% vs 17%&#59; P =0.005). In acute myelogenous leukemia patients, the non-TBI group had better survival tendency (73% vs 38%&#59; P=0.089). The incidence of GVHD, engraftment, survival, cause of death, and late complications was not different between the 2 groups. Conclusion : The TBI and non-TBI groups showed comparable results, but the TBI group showed a significantly higher 5-year EFS than the non-TBI group in ALL patients. Further prospective, randomized controlled studies involving larger number of patients are needed to assess the late-onset complications and to compare the socioeconomic quality of life

    Tetramethyl-O-scutellarin isolated from peels of immature Shiranuhi fruit exhibits anti-inflammatory effects on LPSinduced RAW264.7 cells

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    Purpose: To investigate the anti-inflammatory activity of the ethanol extract of the immature fruit of a citrus, Shiranuhi, and to identify the active ingredient.Methods: The immature Shiranuhi peel was extracted with 80 % ethanol, and the extract was fractionated with solvents (n-hexane, ethyl acetate and n-butanol) to afford the corresponding fractions and water residue. Among them, the EtOAc-soluble portion was subjected to medium pressure liquid chromatography (MPLC) over a reversed-phase SiO2 column to give compound 1. The isolated compound was identified based on the proton and carbon nuclear magnetic resonance (NMR) spectra. The release of nitric oxide, prostaglandin (PG)E2, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 secreted by mouse macrophages was measured using RAW264.7 cell culture supernatant.Results: Shiranuhi (Korean name, Hallabong) is an important citrus species cultivated in Jeju Island, Korea. A polymethoxyflavonoid (PMF), tetramethyl-O-scutellarin (1), was isolated from the peels of immature Shiranuhi fruit. Upon the evaluation of anti-inflammatory effects, the flavonoid 1 decreased the nitric oxide production in macrophage cells with high efficiency, viz, 50 % inhibition concentration, IC50 of 57.4 μM. Subsequent studies demonstrated that PMF 1 effectively inhibited the generation of PGE2, TNF-α, IL-1β, and IL-6 cytokine in a dose-dependent manner.Conclusion: Tetramethyl-O-scutellarin (1) has been successfully isolated from Shiranuhi species for the first time. Thus, Shiranuhi fruit peel extract containing PMF 1 can potentially be applied as an antiinflammatory ingredient in food or cosmetic industries.Keywords: Shiranuhi fruit, Nitric oxide, Tetramethyl-O-scutellarin, Anti-inflammator
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